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DTSTART;TZID=Europe/Paris:20230214T110000
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SUMMARY:SBM seminar invited by A. Bikfalvi : Barak Rotblat
DESCRIPTION:Dr Barak Rotblat seminar:”How do cells survive glucose starvation” \nBarak Rotblat\, Ben Gurion University (BGU)\, Israël is invited by Andreas Bikfalvi (team 01) for a webinar on February 14 at 11am. \nAbstract: Cells use glucose as a primary source of energy and have developed ways to detect changes in glucose levels to activate survival mechanisms. One such mechanism is the inhibition of a protein called mTOR\, which is responsible for controlling cell growth. It was previously thought that this inhibition leads to a reduction in protein synthesis and preservation of ATP\, but our research has found that the true mechanism is actually a decrease in the translation of mRNA that codes for ACC1\, an enzyme involved in fatty acid synthesis. This leads to a decrease in fatty acid synthesis\, NADPH consumption\, and ROS levels. This mechanism is conserved in human. mouse and yeast cells and exploited by tumor cells to generate tumors in the brain\, a low-glucose environment. \nProf. Rotblat studies the molecular biology of cancer by examining the role of long non-coding RNAs and regulators of mRNA translation. Among other functions\, long non-coding RNAs (lncRNA) control regulation in cells. Protein content analysis shows that a cancerous cell is very similar to a normal cell from the same tissue; for example\, a cancerous breast cell is more similar to a breast cell than to a cancerous cell in the lung. However\, while the protein profiles of healthy and cancerous cells from a given tissue are very similar\, their lncRNA content is very different. Therefore\, lncRNA represents a promising drug and therapeutic target. Regulating mRNA translation is key in the cellular mechanism by which tumor cells adapt to stress. Prof. Rotblat and his colleagues seek drug targets and inhibitor molecules aimed at processes that are used by cancer cells to adapt to starvation conditions\, such as found in a tumor. \nZoom ID 873 524 180 13
URL:https://www.bricbordeaux.com/en/event/sbm-seminar-invited-by-a-bikfalvi-barak-rotblat/
LOCATION:visio
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/01/seminaire-b.-rotblat.jpg
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DTSTART;TZID=Europe/Paris:20230228T140000
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CREATED:20230127T110636Z
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UID:42496-1677592800-1677596400@www.bricbordeaux.com
SUMMARY:SBM seminar invited by M. Khatib : Robert Bristow
DESCRIPTION:Séminaire de Robert Bristow : “Evolutionary Trajectory of Aggressive Prostate Cancer: Composite Role of Genomics and Microenvironment” \nRobert Bristow\, Manchester Cancer Research Centre\, will speak on February 28 at 2:00 p.m. in the IBGC conference room\, invited by Majid Khatib (team 2). \n\nRobert Bristow is the Director of Manchester Cancer Research Centre and Director of CRUK Major Centre. He was previously a Clinician-Scientist and Professor within the Departments of Radiation Oncology and Medical Biophysics at the University of Toronto and a Senior Scientist at the Princess Margaret Cancer Centre. His primary research interests are in tumour hypoxia\, DNA damage signalling and DNA repair in tumours\, and the genomics of prostate cancer progression and cancer treatment response. He is particularly interested in novel clinical trials that intensify cancer therapy to prostate cancer patients whose tumours harbour aggressive genetic changes and hypoxic sub-regions. He has over 300 published papers and book chapters. He is twice a Canadian Foundation for Innovation (CFI) awardee. He was made a Canadian Cancer Society Research Scientist in 2004\, an ESTRO Honorary Fellow in 2011 and a Fellow of the Academy of Medical Sciences in 2019. \nNat Commun. 2021 Nov 25;12(1):6893. doi: 10.1038/s41467-021-27223-6.\nNat Commun. 2021 Oct 29;12(1):6248. doi: 10.1038/s41467-021-26489-0.\nCancer Res. 2021 Dec 1;81(23):5833-5848. doi: 10.1158/0008-5472.CAN-21-2056. Epub 2021 Oct 12.\nLancet. 2021 Sep 18;398(10305):1075-1090. doi: 10.1016/S0140-6736(21)00950-8. Epub 2021 Aug 6
URL:https://www.bricbordeaux.com/en/event/sbm-seminar-invited-by-m-khatib-robert-bristow/
LOCATION:salle de conférence IBGC – Carreire\, 146 rue Leo Saignat\, Bordeaux\, 33000\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/01/semainire-sbm-r.-bristow.jpg
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