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X-WR-CALDESC:Events for Bordeaux Institute of Oncology
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DTSTART;TZID=Europe/Paris:20260922T140000
DTEND;TZID=Europe/Paris:20260922T170000
DTSTAMP:20260915T093755Z
CREATED:20260831T100417Z
LAST-MODIFIED:20260915T093755Z
UID:52483-1790085600-1790096400@www.bricbordeaux.com
SUMMARY:Thesis Defense Arthur MARICHEZ
DESCRIPTION:Thesis Defense Arthur MARICHEZ\, team 03 – Liver Cancers and Tumor Invasion \nSpecialization: Cancer Biology \nThesis Supervision Pr Laurence CHICHE \nTitle : Caractérisation du cholangiocarcinome extra-hépatique et développement de modèles prédictifs diagnostiques fondés sur le profilage protéomique. \nTuesday\, September 22\, 2:00 p.m. \nSalle Vasco de Gamma\nCentre Médico-Chirurgical Magellan\nHôpital Haut Lévêque\n1 Avenue de Magellan\n33600 Pessac \nPlease note: The time and location listed in the defense announcement below are incorrect. The defense will take place at 2:00 p.m. in the Vasco de Gamma room.  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-arthur-marichez/
LOCATION:Salle Vasco de Gamma\, Hopital Haut Leveque\, 1 Avenue de Magellan\, Pessac\, 33600
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/08/soutenance-de-these-arthur-marichez-team-3.jpg
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DTSTART;TZID=Europe/Paris:20260929T090000
DTEND;TZID=Europe/Paris:20260929T100000
DTSTAMP:20260731T090748Z
CREATED:20260728T151219Z
LAST-MODIFIED:20260731T090748Z
UID:52296-1790672400-1790676000@www.bricbordeaux.com
SUMMARY:Invited seminar Vincent Hyenne - BRIC team 3
DESCRIPTION:Violaine Moreau and Clotilde Billottet\, from Team 3\, have invited Vincent Hyenne to give a seminar. \nVincent Hyenne is the head of the EXPLORE group at the Tumor Biomechanics lab\, INSERM UMR_S1109\, Centre de Recherche en Biomédecine de Strasbourg. \nThe EXPLORE group is studying the priming of metastatic niches by extracellular vesicles \nTitle : Tumor-derived extracellular vesicles facilitate metastasis onset. \nAbstract \nTumor extracellular vesicles (EVs) promote tumor growth and metastasis by mediating the communication between cancer cells and stromal cells. Yet\, how they are generated and how they spread in the organism to modify the microenvironment in distant organs remains unclear. In the past\, we found that Ral GTPases regulate EVs secretion by maintaining the homeostasis of their compartments of origin\, the multivesicular bodies (MVBs). To explore the molecular and cellular mechanisms through which RalA/B drive exosome secretion\, we characterized their proximal interactome and identified EHD4 as a new Ral partner involved in EV secretion. Using various photonic and electronic imaging approaches\, we propose that Ral-dependent recruitment of EHD4 to MVBs promotes their maturation and movement. In parallel\, we are investigating the function of tumor EVs in the formation of pre-metastatic niches. Combining zebrafish and mouse models\, we show that tumor EVs induce a fast mobilization and activation of neutrophils\, which facilitate metastasis initiation.       \nBiosketch \nVincent loves watching and imaging living (and anesthetized) animals. He did his PhD in Jussieu\, Paris on epithelial polarity in mouse early embryonic development (B. Maro lab). He then moved to IRIC (Labbé lab\, Montreal\, Québec) where he studied the establishment of cell polarity\, and its link with vesicular trafficking in C. elegans. Back in France at the IGBMC (Labouesse lab\, Illkirch)\, he got fascinated by exosomes and extracellular vesicles (EVs) and identified new genes required for their secretion in C. elegans. He joined the Tumor Biomechanics lab\, where he got recruited at CNRS in 2016 to study the secretion\, spreading and function of tumor EVs in metastasis in mice and zebrafish. He is in charge of the fish facility and has to admit that zebrafish\, also not being a nematode\, is pretty cool. Vincent is a board member of the French Society of Extracellular Vesicles (FSEV) and the REVE (Réseau Est des Vésicules Extracellulaires). Vincent loves nothing more than traveling with his family\, except maybe a good book\, or a basketball game\, or a glass of good wine. \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-vincent-hyenne-bric-team-3/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/07/invited-seminar-vincent-hyenne-29-09-2026-1.jpg
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