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DTSTART;TZID=Europe/Paris:20260616T093000
DTEND;TZID=Europe/Paris:20260616T103000
DTSTAMP:20260605T154908Z
CREATED:20260520T080733Z
LAST-MODIFIED:20260605T154908Z
UID:51689-1781602200-1781605800@www.bricbordeaux.com
SUMMARY:BRIC prestige seminar – Lionel LARUE
DESCRIPTION:As part of the prestigious seminars organized by our BRIC unit\, we are pleased to welcome Dr. Lionel Larue\, Inserm Research Director Emeritus\, and Dr. Véronique Delmas (CNRS Research Director) from the Chemistry and Modeling for Cancer Biology team (UMR9187 / U1196) at the Institut Curie. \nWe will take advantage of their visit to organize meetings with the researchers and students in our unit (see internal email) \nTheir research focused on the role of E-cadherin and β-catenin\, as well as other cadherins (such as N- and R-cadherin)\, in embryonic development\, using sophisticated genetically modified mouse models (knockout/knock-in\, etc.)\, contributing to the study of the role of these proteins and their alterations in pathophysiology. \nThey have long been interested in the development of various tissues and cell types\, including the mammary gland and melanocytes\, and their team has made a name for itself particularly in the study of melanoma. \n  \nThe seminar will be presented by Lionel Larue at 9:30 a.m. on Tuesday\, June 16\, 2026\, in a hybrid format \nBBS conference room\, 2 rue Dr Hoffmann Martinot. location map \nZoom ID 871 6813 2700  \nThe presentation will be in English. \n“The CDH1-ESR1-GRPR axis defines a sex-specific metastatic pathways in cancer ” \nAbstract: \nSex differences in cancer remain underexplored\, limiting precision medicine. We show that premenopausal women are more susceptible to certain cancers and identify ECAD as a key mediator of estrogen response. In melanoma\, an ECAD–βCAT–ERα–GRPR pathway drives female-specific tumor aggressiveness\, while targeting GRPR or ERα reduces metastasis. These findings highlight hormone-dependent mechanisms in non-classical cancers and support sex-specific therapeutic strategies\, including GPCR targeting.    \n If scientists from outside the BRIC unit would like to meet with Dr. Lionel Larue and Dr. Véronique Delmas\, please contact David Cappellen at david.cappellen@u-bordeaux.fr. \n  \nLionel Larue CV\nJoin the webinar on Zoom\n  \nCurie Institute report on the article published in Nature in June 2025: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
URL:https://www.bricbordeaux.com/en/event/bric-prestige-seminar-lionel-larue/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2026/05/seminaire-prestige-lionel-larue.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260529T140000
DTEND;TZID=Europe/Paris:20260529T170000
DTSTAMP:20260507T083601Z
CREATED:20260429T090905Z
LAST-MODIFIED:20260507T083601Z
UID:51578-1780063200-1780074000@www.bricbordeaux.com
SUMMARY:Seminar by Bruno Constantin\, invited by Team 4
DESCRIPTION:Dr. Bruno Constantin (CNRS Researcher\, 4CS Laboratory\, University of Poitiers) will give a lecture titled « Ion channels and cancer toward the concept of oncochannels ? » Friday\, May 29\, at 2:00 p.m.\, in the BBS lecture hall. \nEnglish presentation.  \nAbstract \nGrowing evidence indicates that ion channels\, particularly calcium channels\, play central roles in cancer biology. They contribute to key hallmarks of cancer\, including proliferation\, survival\, invasion\, metastasis\, and therapeutic resistance. Cancer stem cells\, in particular\, rely on ion channel–dependent signaling to sustain self-renewal and adaptability. These effects often arise from aberrant channel expression or activity\, enabling cancer cells to hijack physiological signaling pathways. This has led to the emergence of the concept of “oncochannels\,” referring to ion channels that actively drive tumor initiation and progression. Beyond improving our understanding of cancer pathophysiology\, this concept identifies ion channels as promising biomarkers and therapeutic targets. \nBiosketch \nWith a Master’s degree in Physiology and Cellular Biology (electrophysiology\, University of Poitiers)\, my research focuses on calcium signaling in physiology and disease. My early work addressed calcium dynamics during myogenesis and actin cytoskeleton remodeling (Ghent University).  \nAt CNRS\, I demonstrated the role of dystrophin in calcium homeostasis and ion channel regulation in skeletal muscle\, leading to studies on TRPC/α-syntrophin complex and their involvement in Duchenne muscular dystrophy\, as well as the therapeutic potential of mini-dystrophin. \nSince 2014\, I directed STIM and 4CS lab. My research has expanded to cancer and stem cell biology and has focused on calcium channels in neural and cancer stem cells\, particularly store-operated calcium entry (SOCE)\, and their roles in glioma cell self-renewal and invasion. I have also contributed to projects on TRP channels in invasive cancer cell migration across various cancer models.
URL:https://www.bricbordeaux.com/en/event/seminar-by-bruno-constantin-invited-by-team-4/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2026/04/invited-seminar-bruno-constantin-29-05-2026-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260506T133000
DTEND;TZID=Europe/Paris:20260506T170000
DTSTAMP:20260429T072629Z
CREATED:20260428T135446Z
LAST-MODIFIED:20260429T072629Z
UID:51558-1778074200-1778086800@www.bricbordeaux.com
SUMMARY:Defense of thesis Mariana SARAIVA\, team 4
DESCRIPTION:Defense of Mariana SARAIVA‘s thesis in Cancer Biology\, team 4 Digestive cancers associated with Helicobacter infection\, cancer stem cells and therapeutic strategies \nThesis supervision Armelle Ménard \nImplication des génotoxines bactériennes dans le remodelage du cytosquelette cellulaire et la carcinogenèse. \nWednesday\, May 6\, 1:30 p.m.\nBBS Conference Room\, 2 Rue du Dr. Hoffmann Martinot\, Bordeaux \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-mariana-da-silva-saraiva-team-4/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2026/04/soutenance-de-these-mariana-saraiva-team-4.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260413T160000
DTEND;TZID=Europe/Paris:20260413T190000
DTSTAMP:20260408T094156Z
CREATED:20260407T152059Z
LAST-MODIFIED:20260408T094156Z
UID:51426-1776096000-1776106800@www.bricbordeaux.com
SUMMARY:Thesis Defense Yiyang LIU\, team 2 RyTme
DESCRIPTION:Thesis Defense in Cancer Biology \nYiyang LIU\, team 2 RyTme\, co-supervision of thesis Majid Khatib and John W.M. Creemers (Laboratory of Biochemical Neuroendocrinology\, Center for Human Genetics\, KU Leuven\, Belgium) \n“The role of Furin in KRAS- and BRAF-mutant colorectal cancer” \nMonday\, April 13\, 4:00 p.m.\nAuditorium BMW 1\, ON2\, Campus Gasthuisberg\, KU Leuven\nLivestream: https://livestream.kuleuven.be (PIN: 063194)
URL:https://www.bricbordeaux.com/en/event/thesis-defense-yiyang-liu-team-2-rytme/
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2026/04/soutenance-de-these-yiyang-liu-team-2-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T100000
DTEND;TZID=Europe/Paris:20260319T170000
DTSTAMP:20260310T141853Z
CREATED:20251216T163329Z
LAST-MODIFIED:20260310T141853Z
UID:50745-1773914400-1773939600@www.bricbordeaux.com
SUMMARY:Seminar: “3D Models in Oncology” - From Design to Analysis
DESCRIPTION:Seminar  \n“3D Models in Oncology”\nFrom Design to Analysis \n  \nThe BRIC 3D Models Working Group – The Bordeaux Institute for Cancer Research (BRIC) is organizing a day dedicated to 3D models in oncology. Oral presentations will be in French and supporting materials in English.\n\n \nThursday\, March 19\, 2026 \n10am-17pm\nBordeaux\nconference room BBS – Bordeaux\, Biologie\, Santé\nor video : webinar zoom link\n(Webinar ID 885 7708 5527\, code 1903) \n  \nSign up here! \n  \n\nInvited scientists \nAudrey Ferrand\, CR INSERM – INSERM U1297\, Toulouse\nVéronique Maguer-Satta\, DR CNRS – INSERM U1052\, Lyon\nIsabelle Dupin\, PR Université de Bordeaux – INSERM U1045\, Bordeaux\nFlorent Ginhoux\, PR Université Paris Saclay – INSERM U1015\, Paris\nFlorian Levet\, IR Inserm – IINS / BIC\, Bordeaux\n \n  \nBRIC presentations and platforms  \n\n  \nDetailed program \n  \n#CellModel #Oncology #3DModel #Networking #TechnologyPlatforms #ScientificMeetings \n\nIn partnership with:\n\n\nFree event – registration required before March 6 \n  \nSign up here! \n  \nSponsoring and information :\nSandrine Poglio : sandrine.poglio@u-bordeaux.fr\nLaurence Bresson-Bepoldin : laurence.bresson-bepoldin@inserm.fr \n\nThanks to our sponsors
URL:https://www.bricbordeaux.com/en/event/seminar-3d-models-in-oncology-from-design-to-analysis/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260310T140000
DTEND;TZID=Europe/Paris:20260310T170000
DTSTAMP:20260302T132858Z
CREATED:20260210T161119Z
LAST-MODIFIED:20260302T132858Z
UID:51067-1773151200-1773162000@www.bricbordeaux.com
SUMMARY:Thesis defense Marianne Guilbard
DESCRIPTION:Thesis defense in Cancer Biology. \nMarianne Guilbard\, team 2 Oncogyne\, Frederic Delom \n“Tumor-adaptive functions of the secreted protein disulfide isomerase AGR2.” (thesis defense in french) \nTuesday\, March 10 at 2 p.m. \nBibliothèque\nInstitut Bergonié\, 229 cours de l’Argonne\, 33000 Bordeaux\, France \n\nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-marianne-guilbard/
LOCATION:Institut Bergonié\, 229 Cours de l'Argonne\, Bordeaux\, 33076\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260224T143000
DTEND;TZID=Europe/Paris:20260224T153000
DTSTAMP:20260226T151449Z
CREATED:20260202T151141Z
LAST-MODIFIED:20260226T151449Z
UID:50956-1771943400-1771947000@www.bricbordeaux.com
SUMMARY:Andreas Bikfalvi seminar - The complexity of causality in cancer: A scientific and philosophical investigation
DESCRIPTION:Andreas Bikfalvi\, Professor Emeritus at the University of Bordeaux\, affiliated with BRIC Team 1\, recently defended a thesis in philosophy at the Sorbonne He offers us a summary of this in this seminar. \n“The complexity of causality in cancer: A scientific and philosophical investigation” \n📅 Tuesday\, February 24\, 2:30 p.m. \n🚩 BBS (Bordeaux Biology Health) conference room – 2 rue du Dr Hoffmann Martinot Bordeaux (Carreire site\, University of Bordeaux) \nor by video conference \nAbstract \nMy work explores the complex nature of causality in cancer biology\, particularly within the tumor microenvironment (TME)\, integrating philosophical perspectives\, mathematical modeling\, and experimental data. It traces the evolution of cancer theories from cell-based to microenvironment-focused models\, highlighting increased complexity in causal interpretation due to tumor heterogeneity. The “Hallmarks of Cancer” framework is discussed as a descriptive tool that lacks causal clarity\, prompting the use of multi-scale and formal causal models. \nTwo main theoretical approaches—Somatic Mutation Theory and Tissue Organization Field Theory—are compared and integrated\, with probabilistic models illustrating the variable influence of genetics\, cellular environment\, and microenvironmental factors. Case studies on diffuse gliomas and clear cell renal carcinoma demonstrate how advanced causal modeling (using DAGs\, SEM\, and Bayesian approaches) can clarify the interplay among invasion\, immunity\, metabolism\, and genetic mutations. The research also identifies key molecular pathways and therapeutic targets. \nMethodologically\, the work highlights the challenges of validating complex causal networks and advocates for systematically integrating causal analysis in biomedical research. A holistic\, interdisciplinary approach is essential for advancing both fundamental understanding and clinical applications in oncology. Additionally\, it is shown how biomedical research can enhance philosophical conceptual analysis and philosophical concepts biomedical research \nBiosketch \nBorn in Hungary and raised in Germany\, I hold both French and German citizenships. I graduated in medicine in France and completed my residency in hematology and oncology at the University of Kiel (Germany). I then pursued a PhD in science at INSERM in Paris\, where my research focused on the biology of growth factors\, particularly FGFs\, and their role in regulating the phenotype of endothelial cells.  \nIn 1991\, I joined Professor Daniel B. Rifkin’s laboratory in New York\, where I studied the mechanisms of action of different molecular forms of FGFs. Upon returning to France in 1995\, I joined the CNRS and then the University of Bordeaux as a professor of cell and molecular biology\, where I established and led a laboratory dedicated to tumor and vascular biology\, affiliated with INSERM as of 2000. My unit became part of the BRIC INSERM center in Bordeaux in 2022 (Team 1 of BRIC) Since 2025\, I am an emeritus professor. Alongside my scientific activities\, I am also involved in philosophy of science and earned a doctorate in this field from Paris 1 Panthéon-Sorbonne. \n  \nSee the replay : \n[vc_video link=’https://youtu.be/2BnstxoRyEo’]
URL:https://www.bricbordeaux.com/en/event/andreas-bikfalvi-seminar-the-complexity-of-causality-in-cancer-a-scientific-and-philosophical-investigation/
CATEGORIES:Meetings,Scientific seminars
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END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260131
DTEND;VALUE=DATE:20260201
DTSTAMP:20260120T165008Z
CREATED:20250625T130142Z
LAST-MODIFIED:20260120T165008Z
UID:50850-1769817600-1769903999@www.bricbordeaux.com
SUMMARY:Digestive Cancer Open Day 2026
DESCRIPTION:2026 Open Day on Digestive Cancers on Saturday\, January 31\, 2026. \nBRIC is once again holding an Open Day at its premises in Bordeaux\, on the Carreire campus (BBS building). Find information on our website dedicated to the general public:  \n  \npatient website \n  \nThis initiative\, which is fully in line with the goal of scientific outreach\, aims to introduce the general public\, in a variety of formats\, to the daily lives of researchers and recent advances in the field of digestive cancer research. The programme includes : \n\n\nContinuous reception (except from 12:30 p.m. to 1:45 p.m.)\n\n\n\nSeminars on the Cancer Research/Care and Innovation Ecosystem in the Region (11 a.m. and 2 p.m.)\n\n\n\nInteractive guided tours of the laboratory\, including 3 workshops:\n\nWorkshop: “Discovering Living Cells”\n\n\n\nWorkshop: “The journey of a sample”: from biopsy to treatment\n\n\n\nEscape Game Workshop\n\n\n\n\n\nWorkshops on “Observation of tumor tissues” (ongoing)\n\n\n\nExchange activity: “Ask all your questions” (ongoing)\n\n\n\nGuided discoveries into the mechanisms of cancer\, drug development\, and various therapies. (ongoing)\n\n\n\nStand of the Gironde Cancer League (continuous)\n\n\n\nDiscovery of a biological model (ongoing)\n\n\nTours departing with workshop participation at 10 a.m.\, 11 a.m.\, 2 p.m.\, and 3 p.m. Other activities ongoing throughout the day. \n\nCome and discuss\, around posters or mini-seminars\, with various contributors involved in the research: – Academic research professionals (researchers and teacher-researchers\, engineers and technicians\, doctoral students and interns) – Clinical research professionals – Clinicians\, including surgeons and oncologists \n\nPatient associations\, including La Ligue Contre le Cancer de Gironde (the Gironde Cancer League) and a start-up company spun off from the laboratory\, will also be present! \n\nCome visit the laboratory and take the opportunity to put on a lab coat and gloves and participate in fun workshops! This project is led by teams 3\, 4\, and 8 at BRIC\, in collaboration with several supervisory bodies (Inserm\, University of Bordeaux) and scientific partners: (Bordeaux University Hospital\, OncoProt\, BeLiver\, Bergonié Institute). \n  \nAccess: \n🚘Apart from the parking spaces reserved for university staff (badge required)\, you will find spaces closer by on the sidewalk along the wall on Rue du Dr Hoffmann Martinot. Otherwise\, there is a parking lot reserved for visitors a 5-minute walk away\, located at 125 Bethmann Street. \n🚊Take tram A to the Saint Augustin stop\, then follow the “cycles et piétons” (cycles and pedestrians) markings on the ground across the CHU campus. \n🚍Several bus lines nearby\, see location map \n  \nlocation map
URL:https://www.bricbordeaux.com/en/event/digestive-cancer-open-day-2026/
LOCATION:Accueil bâtiment Bordeaux Biologie Santé (BBS)\, 2 rue Dr Hoffmann Martinot\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/06/vignette-jpo-cancers-digestifs-bric-31-01-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260127T140000
DTEND;TZID=Europe/Paris:20260127T150000
DTSTAMP:20260106T111830Z
CREATED:20260106T111830Z
LAST-MODIFIED:20260106T111830Z
UID:50730-1769522400-1769526000@www.bricbordeaux.com
SUMMARY:Invited Seminar Kevin Boyé
DESCRIPTION:We invite Kevin Boyé to give a seminar open to the scientific community. \nDr. Kevin Boyé\nCRCN INSERM Paris Cardiovascular Research Center – 56 Rue Leblanc\, 75015 Paris\nCo-founder of D2B3 – 101 College Street\, 06511 New Haven\, CT\, USA \n \n“Unlocking the Blood–Brain Barrier during Glioblastoma progression” \n📆 Tuesday\, January 27\, 2 p.m.\n🚩 BBS Conference Room\, 2 rue Dr Hoffmann Martinot\, Carreire site\, University of Bordeaux \nAbstract \nBlood vessels in the brain form 600 kilometers of specialized blood-brain barrier (BBB) that protect the brain from toxins and pathogens\, thereby ensuring homeostasis and proper neurological function. However\, BBB impermeability also severely limits brain drug delivery during many neurological disorders. \nGlioblastoma (GBM) is the most aggressive primary brain tumor with a median survival of 12–15 months. Although BBB integrity is partially disrupted within the tumor core\, the highly invasive nature of GBM cells into the BBB-competent brain parenchyma strongly limits the delivery and efficacy of therapeutic molecules\, leading to inevitable recurrence after surgical resection. Hence\, developing tailored therapeutic strategies that can transiently and safely modulate BBB permeability without compromising its protective function remains a major unmet clinical need. \nWe recently identified the endothelial receptor Unc5B and its ligand Netrin-1 as central regulators of BBB integrity. Single-cell RNA sequencing revealed that this pathway controls a core BBB gene expression program of over 100 genes involved in tight junction organization\, nutrient and ion transport\, and efflux pump function. To harness this mechanism therapeutically\, we developed\, optimized\, and patented a fully human monoclonal antibody (Anti-Unc5B) that specifically blocks Netrin-1 binding to Unc5B. \nFollowing intravenous injection\, Anti-Unc5B induces a brain-wide and brain-specific\, opening of the BBB for up to six hours\, prior to barrier resealing. This transient permeability window is size-selective\, cumulative and safe. Using this BBB-permeabilizing strategy\, we could enhance the delivery and efficacy of a wide variety of therapeutic molecules including chemotherapies\, tyrosine kinase inhibitors and nanobodies during GBM progression\, resulting in increased tumor cell apoptosis\, reduced tumor growth and improved survival. \nBiosketch \nI completed my PhD in the laboratory of Pr. Andreas Bikfalvi under the supervision of Dr. Clotilde Billottet (INSERM U1029\, France)\, where I identified the chemokine receptor CXCR3-A and its ligand CXCL4L1 as a novel signaling pathway essential for brain tumor progression (Boyé K. et al.\, Nature Communications 2017; Boyé K. et al.\, Scientific Reports 2017; Quemener C et al. Cancer Research 2016). However\, like most therapeutic molecules developed for neurological diseases\, intravenously injected CXCR3-A inhibitors were unlikely to efficiently cross the blood–brain barrier (BBB). \nTo overcome this limitation\, I joined the laboratory of Pr. Anne Eichmann at Yale University (New Haven\, USA) as a postdoctoral fellow (2017-2022)\, where I investigated mechanisms regulating vascular barrier integrity (Genet G.\, Boyé K. et al. Nature Communication 2019; Zhang F. et al. Science 2018)\, with a particular focus on the BBB (Boyé K. et al.\, Nature Communications 2022). I identified the endothelial Unc5B receptor and its ligand Netrin-1 as a key signaling pathway required to maintain BBB integrity. I subsequently developed a human monoclonal antibody that block Netrin-1 binding to Unc5B\, enabling a reversible and controlled BBB opening leading to brain delivery of bioactive molecules (Two Patents in 2023). \n  \nSince 2023\, I am a Group Leader (CRCN) at the Paris Cardiovascular Research Center (INSERM U970). My group is currently funded by an FRM “Amorçage jeunes équipes” (2023-2026)\, an ANR PRC (Coordinator; 2026 – 2028) and an INCa PLBIO (Coordinator; 2026 – 2028). My research program focuses on: \n\nOptimizing brain drug delivery beyond the BBB during brain tumor progression.\nEnhancing BBB integrity in diseases with BBB dysfunction.\n\nWe recently reported a BBB gene-expression program zonated along the arteriovenous axis that can be tuned to increased brain drug delivery (Furtado et al.\, PNAS 2024). \n  \nIn 2024 I co-founded D2B3 (https://d2b3.bio)\, a start-up company spun out of Yale University\, aiming to improve brain drug delivery in patients using our patented BBB-permeabilization technology.
URL:https://www.bricbordeaux.com/en/event/invited-seminar-kevin-boye/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2026/01/invited-seminar-kevin-boye-27-01-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251218T140000
DTEND;TZID=Europe/Paris:20251218T170000
DTSTAMP:20251216T160428Z
CREATED:20251216T160142Z
LAST-MODIFIED:20251216T160428Z
UID:50583-1766066400-1766077200@www.bricbordeaux.com
SUMMARY:Thesis defense Zahraa FAKIH - team 05
DESCRIPTION:Thesis defense in Cell Biology and Physiopathology of Zahraa FAKIH \n🎤 Études Moléculaires des Anomalies de Pigmentation dans Le Xeroderma Pigmentosum de Type C\nThesis supervisor : Muriel CARIO équipe 5 – Recherche translationnelle en cancérologie cutanée et maladies cutanées rares (TRIO2). \n📅 Thursday\, December 18\, 2025\, 2:00 p.m.\n🚩 salle de conférence BBS – 2 rue Docteur Hoffman Martinot\, Site Carreire\, 33000\, Bordeaux \n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-zahraa-fakih-team-05/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
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END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251217T140000
DTEND;TZID=Europe/Paris:20251217T170000
DTSTAMP:20251211T163743Z
CREATED:20251211T163046Z
LAST-MODIFIED:20251211T163743Z
UID:50556-1765980000-1765990800@www.bricbordeaux.com
SUMMARY:Thesis defense Lucile Rouyer\, team 3
DESCRIPTION:Thesis defense in Cancer Biology by Lucile Rouyer\, team 03 – Liver Cancers and Tumor Invasion \n\n\n\n\nThesis supervisor : Frederic Saltel \n“Étude et modélisation in vitro des interfaces au cours de la progression tumorale.” \n\n\n\n\n📅 Wednesday\, December 17\, 2 p.m. \n\n\n🚩 Amphi BBS\, campus Carreire\, Université de Bordeaux \n\n\n\n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-lucile-rouyer-team-3/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/12/soutenance-de-these-lucile-rouyer.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251212T140000
DTEND;TZID=Europe/Paris:20251212T170000
DTSTAMP:20251208T174943Z
CREATED:20251208T174136Z
LAST-MODIFIED:20251208T174943Z
UID:50523-1765548000-1765558800@www.bricbordeaux.com
SUMMARY:Thesis defense: Thibaut Matis - Team 8
DESCRIPTION:Thesis defense in Genetics of Thibaut Matis\, team 8 – Biotherapies Genetics and Oncology (BioGO) \n\n\n\n\n“CISCO : Etude des régions CIS régulatrices de l’expression du gène PTEN et leur implication dans la maladie de COwden.” \nThesis supervision : Nicolas Sevenet \n\n\n\n\n📆 Friday\, December 12\, 2 p.m \n\n\n🚩 Lecture Hall 12\, Carreire Campus\, 146 rue Leo Saignat Bordeaux (To find Lecture Hall 12 from the BBS\, follow the map) \n\n\n\nnotice of defense with summary \n 
URL:https://www.bricbordeaux.com/en/event/thesis-defense-thibaut-matis-team-8/
LOCATION:amphi 12\, site Carreire\, 146 rue Leo Saignat\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/12/soutenance-de-these-thibaut-matis.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251210T140000
DTEND;TZID=Europe/Paris:20251210T170000
DTSTAMP:20251204T164723Z
CREATED:20251204T163408Z
LAST-MODIFIED:20251204T164723Z
UID:50495-1765375200-1765386000@www.bricbordeaux.com
SUMMARY:Thesis defense Lea Pechtimaldjian\, team Trio2
DESCRIPTION:Soutenance de thèse de Léa Pechtimaldjian\, équipe Equipe: 5.2 Cutaneous lymphomas\, Vascular tumors\, Tissue engineering (M. Beylot-Barry\, L. Bresson-Bepoldin) \nTitre de thèse: “Etudes des télocytes cutanés dans l’hémangiome infantile: caractérisation\, propriétés angiogéniques et approches thérapeutiques” \nSpécialité: Biologie cellulaire et physiopathologie \nDirecteur de thèse: François Moisan \nMercredi 10 décembre 2025\, 14h\nAmphi BBS\, 2 rue Dr Hoffmann Martinot Bordeaux \n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-lea-pechtimaldjian-team-trio2/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/12/soutenance-de-these-lea-pechtimaldjian.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251210T110000
DTEND;TZID=Europe/Paris:20251210T120000
DTSTAMP:20251204T154347Z
CREATED:20251204T154347Z
LAST-MODIFIED:20251204T154347Z
UID:50485-1765364400-1765368000@www.bricbordeaux.com
SUMMARY:Invited seminar Bernhard Wehrle-Haller
DESCRIPTION:On the occasion of Léa Pechtimaldjian‘s thesis\, Team 5 (TRIO2) invites Bernhard Wehrle-Haller\, member of the jury\, to present a seminar to the scientific community. \nBernhard Wehrle-Haller PhD\nUniversity Medical Center\, Geneva\, Switzerland \n“The multiple roles of integrins in the assembly of fibronectin fibrils in the tumor stroma” \nAbstract:\nThe formation and growth of tumors depends on oxygen supply\, but also on mechanical support through increased synthesis of the extracellular matrix. Increased extracellular matrix stiffness enhances the survival capacity of tumor cells under therapeutic stress. At the same time\, tumor cells stimulate host cells to produce a supportive extracellular matrix. The mechanisms of this feedback are not well understood\, and there is no treatment to reverse the fibrotic response in the tumor stroma. Since integrins are essential receptors for tumor binding to the extracellular matrix\, but are also involved in the synthesis of extracellular matrix fibers\, we asked about the nature of intracellular connections and intracellular signaling that control how integrins are used by tumor or stromal cells in tumors. In a clinical approach\, we analyzed different types of glioblastoma to better understand the physiological roles of integrins in this type of cancer. \nBiography:\nStudied biochemistry in Basel\, Switzerland; Thesis in the field of extracellular matrix (tenascin\, laminin\, fibronectin\, and neurite growth)\, Biozentrum Basel\, Switzerland; Postdoc: in Oregon\, US\, directional migration of embryonic melanoblasts and role of growth factors; Return to Switzerland\, Geneva\, then appointment as Associate Professor\, role of integrin family receptors in cell adhesion and migration.  \n  \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-bernhard-wehrle-haller/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/12/bernhard-wehrle-haller-2025-12-10.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251114T140000
DTEND;TZID=Europe/Paris:20251114T150000
DTSTAMP:20250729T144312Z
CREATED:20250729T144312Z
LAST-MODIFIED:20250729T144312Z
UID:49802-1763128800-1763132400@www.bricbordeaux.com
SUMMARY:Invited seminar Etienne Brecht & Aurélie Beaufrère - 2025-11-14
DESCRIPTION:Marion Bouchecareilh et Samuel Amintas from Team 8 “Genetic Biotherapies and Oncology” (BioGO) invite two speakers from Paris Cité University\, Center for Inflammation Research\, INSERM 1149\, Sinkus Team (From micro to macro in cancer development) for this seminar open to the scientific community. \n👉 Aurélie Beaufrère \nMorphological and molecular heterogeneity of hepatocellular carcinoma. \nAbstract:\nHepatocellular carcinoma is the most common primary malignant liver tumor. This tumor is highly heterogeneous\, both morphologically\, with eight histological subtypes described\, and molecularly\, with distinct transcriptomic groups described that are linked to both genomic alterations and morphological aspects. Some of these characteristics impact both prognosis and response to treatment.   \nBiography:\nCurrently an MCU-PH in the Pathology Department at Beaujon Hospital\, my hospital and research work focuses on liver pathology\, particularly liver tumors. I am developing projects on the morphological and molecular heterogeneity of primary liver tumors\, as well as multimodal artificial intelligence projects integrating pathological\, radiological\, and molecular data.  \n  \n👉 Etienne Becht \nHigh-throughput single-cell quantification of 100s of proteins using conventional flow cytometry and machine learning. \nAbstract: \nTechniques enabling single-cell resolution proteomic analyses are limited in terms of the number of cells analyzed and/or the number of proteins measured. To overcome these limitations\, we have developed “Infinity Flow\,” a method for analyzing flow cytometry data in parallel using machine learning models. By enabling the pseudo-quantification of hundreds of proteins in millions of single cells\, this technique allows for in-depth mapping of the microenvironment of complex tissues. We are currently applying it to the study of liver cirrhosis and hepatocellular carcinoma.    \nBiography: \nAs an engineer by training\, I completed a thesis in cancer immunology under the joint supervision of Hervé Fridman (PUPH) and Aurélien de Reyniès (bioinformatician) at the Cordeliers Research Center in Paris. There\, I developed MCP-counter\, a method for estimating the composition of the tumor microenvironment from the bulk transcriptome. I then completed two postdoctoral fellowships\, first at the Singapore Immunology Network on mass cytometry data analysis\, then in Seattle on parallelized flow cytometry data analysis. I then worked in R&D at Servier (Computational Medicine team) before joining Valérie Paradis’ laboratory at the hospital as an INSERM research fellow. My project focuses on profiling the hepatic microenvironment using parallelized flow cytometry and developing bioinformatics methods for analyzing cytometry data.     \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-etienne-brecht-aurelie-beaufrere-2025-11-14/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/07/seminaire-e-brecht-aurelie-beaufrere-2025-11-14.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251113T100000
DTEND;TZID=Europe/Paris:20251113T113000
DTSTAMP:20251031T135221Z
CREATED:20251031T135221Z
LAST-MODIFIED:20251031T135221Z
UID:50307-1763028000-1763033400@www.bricbordeaux.com
SUMMARY:Graduate program Cancer Biology invited seminar - Raul V. DURAN
DESCRIPTION:The lecturers and professors of the Graduate Program in Cancer Biology invite Raul V. Duran to give a lecture in Bordeaux on Thursday\, November 13\, from 10:00 a.m. to 11:30 a.m. in the conference room of the BBS building\, 2 rue du Dr Hoffmann Martinot.\nRaul Duran will be available on Wednesday\, November 12\, during the morning\, to talk with researchers who wish to meet him.\nContact: jose-eduardo.gomes@u-bordeaux.fr\n\n\nRaul V. Duran\nSpanish National Research Council (CSIC) – Séville\nGroup Leader of the Group of Metabolism and Cell Signaling\n \n“Metabolic imbalance as a therapeutic strategy in cancer.” \n  \nAbstract \nDuring last years\, a great amount of effort has been dedicated to elucidate the crosstalk between cellular metabolic and bioenergetic flows with signaling processes\, and how this interaction contributes to coordinate the growth and homeostasis of cells and tissues. Particularly\, how these interaction mechanisms are deregulated in cancer at the molecular and cellular level is a matter of intense research\, with the aim of using this knowledge to propose new therapeutic alternatives. Our research has established the processes of interaction between the metabolism of the amino acid glutamine\, the most abundant in human blood and the most important from an energetic point of view for cells\, with cell signaling via the mTOR pathway\, a protein complex essential in the regulation of cell growth and metabolism\, and autophagy. More recently\, we focused our research on metabolic adaptation associated to therapy resistance in glioblastoma (GBM)\, one of the tumor types with the poorest survival outcomes. This work resulted in the identification of FGFR1 pathway as a major regulator of the signaling and metabolic rewiring associated with temozolomide (TMZ) resistance in GBM. Hence\, we described a mechanism of resistance that operates at two major levels. First\, a p53-mediated regulation of cell cycle inducing cell cycle arrest to allow DNA repair in response to TMZ. And second\, a complete metabolic rewiring promoting lipid catabolism and preventing lipid peroxidation. Both the p53-mediated response and the metabolic adaptation are controlled by FGFR1\, as inhibition of the FGFR1 pathway completely abolishes this signaling and metabolic reprograming\, restoring sensitivity to TMZ. Our results also indicated a correlation of FGFR1 activity with poor prognosis in GBM patients\, and validated the treatment of TMZ in combination with FGFR1 inhibitors as an efficient strategy to induce tumor cell death in pre-clinical animal models. This data position the receptor FGFR1 as a very promising candidate for evaluation in future clinical approaches to limit the development of therapy resistance to TMZ in GBM patients. \n  \nBiosketch \nI obtained my PhD in Biochemistry at the University of Seville (Spain) in 2005 working on cellular bioenergetics. Then\, I joined the lab of Prof. Eyal Gottlieb at the Beatson Institute for Cancer Research (Glasgow\, UK) as a postdoctoral researcher to extend my expertise on broader aspects of cancer metabolism. Later\, I moved to the lab of Prof. Michael N. Hall at the Biozentrum (Switzerland) as a senior postdoc to study the de-regulation of cellular signaling during cancer. In 2013 I joined the Institut Européen de Chimie et Biologie (Pessac\, France) as a Group Leader (INSERM\, CR position)\, integrating my previous expertise to investigate the crosstalk between metabolism and cell signaling in cancer cells. In 2018 I moved my lab to the Centro Andaluz de Biología Molecular y Medicina Regenerativa – CABIMER\, upon my assignment as Senior Research Associate (Científico Titular) at CSIC. Since them\, I am the Group Leader of the Group of Metabolism and Cell Signaling\, and in the period 2019-2022 I was the Director of the Department of Dynamics and Cell Signaling at CABIMER. In the period 2020-2024 I was the Deputy Director of CABIMER. Currently\, I am a member of the Executive Committee of the CONEXION CANCER-CSIC\, and I serve as Associate Editor of the journal Cancer & Metabolism. Since January 2025 I serve as permanent evaluator (Gestor) of the Spanish Agency of Investigation (AEI)\, in the Biomedicine – Cancer commission.
URL:https://www.bricbordeaux.com/en/event/graduate-program-cancer-biology-invited-seminar-raul-v-duran/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/10/seminaire-invite-graduate-schhol-cancer-raul-v-duran.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251023T103000
DTEND;TZID=Europe/Paris:20251023T113000
DTSTAMP:20250929T081714Z
CREATED:20250929T081714Z
LAST-MODIFIED:20250929T081714Z
UID:50101-1761215400-1761219000@www.bricbordeaux.com
SUMMARY:Invited seminar Thamil Selvee Ramasamy - 23-10-2025
DESCRIPTION:Thamil Selvee Ramasamy\nStem Cell Research Laboratory\, Department of Molecular Medicine\, Faculty of Medicine\, Universiti Malaya\, Kuala Lumpur\, MALAYSIA. \nInvited by Delphine Fessart and the Oncology and Gynaecology (OncoGyne) Laboratory head by Frederic Delom \nThursday\, October 23 at 10:30 a.m.\, BBS conference room\, 2 rue du Dr Hoffmann Martinot \nStem Cell Plasticity in Developmental Biology\, Regenerative Medicine and Cancer \nShort biosketch: Dr. Ramasamy earned her PhD in Clinical Medicine Research Programme (specialisation: human embryonic stem cell research) from Imperial College London\, UK. She is currently serving as an associate professor at the Department of Molecular Medicine and heading the Stem Cell Biology Laboratory at Universiti Malaya\, Malaysia. Exploring the potential of stem cells in development of therapy for degenerative diseases and targeting cancer stem cells are the primary focus of her research. More details can be found in her page: umexpert.um.edu.my/selvee.html and Web of Science Researcher IDF-3044-2012. \n\nAbstract  \nStem cell plasticity is the key concept in developmental biology\, enabling the zygote and inner cell mass to give rise to all 208 specialized cell types through exquisitely precise signalling and cell–cell communication. I will share on how embryonic stem cells can be used to understand and engineer cell fates\, focusing on my work on neuronal and hepatic differentiation. Both embryonic and adult stem cells offer a versatile reservoir for generating therapeutically relevant cells in regenerative medicine\, this talk will cover the work done in our laboratory on developing regenerative therapies using stem cells in combination with other approaches.  \nIntriguingly\, in oncology\, cancer stem cell plasticity fuels tumour heterogeneity\, therapy resistance\, and relapse\, presenting persistent challenges for effective treatment. In the interest of BRIC researchers\, I will devote most of my talk to how we model cancer stem cells in culture\, using these models to unravel the molecular regulation governing plasticity in malignant contexts\, with a particular focus on hepatocellular carcinoma. Since the direction of our current work aims to leverage cutting-edge technologies including spatial transcriptomics\, nanotechnology-based drug delivery\, drug repurposing\, and cancer immunotherapy to intercept cancer stem cell plasticity and advance precision oncology\, I would like explore your expertise and discuss potential collaborations with BRIC researchers in this domain. \n  \nContact to meet Thamil Selvee Ramasamy : Delphine Fessart : delphine.fessart@inserm.fr
URL:https://www.bricbordeaux.com/en/event/invited-seminar-thamil-selvee-ramasamy-23-10-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/09/thamil-selvee-ramasamy-2025-10-23-v2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251013T090000
DTEND;TZID=Europe/Paris:20251013T130000
DTSTAMP:20250925T093649Z
CREATED:20250925T093649Z
LAST-MODIFIED:20250925T093649Z
UID:50143-1760346000-1760360400@www.bricbordeaux.com
SUMMARY:Thesis defense by Chloé Redouté-Timonnier
DESCRIPTION:Chloé Redouté-Timonnier\n\, team 6 MIRCADE will defend her thesis in cancer biology on Monday\, October 13\, at 9 a.m. in the lecture hall of the Bordeaux Biology Health (BBS) building at the University of Bordeaux – 2 rue du Dr Hoffmann Martinot\, Bordeaux. \nImpact des isoformes DDR1a et DDR1b sur le développement du carcinome rénal à cellules claires (ccRCC). \nThesis supervisor Patrick Auguste. \nSummary in the defense notice at this link \nJury members:\nM. Ulrich VALCOURT – Laboratoire de Biologie Tissulaire et Ingénierie Thérapeutique (LBTI) UMR 5305 CNRS et Université Claude Bernard Lyon 1\, Rapporteur\nM. Curzio RUEGG – University of Fribourg\, Switzerland\, Rapporteur\nMme Elisabeth GENOT – Bioingénierie Tissulaire (BioTis) Inserm U1026 Université Bordeaux\, Examinatrice\nM. Hamid MORJANI – BioSpectroscopie Translationnelle BioSpecT – EA7506 UFR de Pharmacie – Université deReims\, Examinateur\nMme Isabelle SAGOT – IBGC UMR 5095 – Université de Bordeaux\, Examinatrice
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-chloe-redoute-timonnier/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/09/soutenance-de-these-chloe-redoute-timonnier.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250929T140000
DTEND;TZID=Europe/Paris:20250929T170000
DTSTAMP:20250918T132717Z
CREATED:20250808T100416Z
LAST-MODIFIED:20250918T132717Z
UID:49855-1759154400-1759165200@www.bricbordeaux.com
SUMMARY:Thesis defense by Florian ROBERT
DESCRIPTION:Thesis defense in computer science \nFlorian ROBERT\, team 06 – MIRCADE\, Methods and Innovations for the Research in Pediatric Cancers. \nCo-supervision of thesis: Christophe Grosset (BRIC) and Baudouin Denis de Senneville (IMB- Institut des Mathématiques de Bordeaux) \nMonday\, September 29\, 2 p.m. \n“Exploration de l’organisation interne des tissus tumoraux par imagerie volumétrique\, méthodes numériques et apprentissage profond.” \nSalle des Actes bâtiment A33 campus Sciences et Technologies à Talence \nAbstract: \nUnderstanding the internal organization of tumor tissues is essential for improving cancer treatment in children. This thesis focuses on hepatoblastoma\, the most common malignant liver tumor in children. Based on 3D electron microscopy images\, a digital twin of the tumor tissue was created using innovative tools to automatically segment and identify biological structures such as cells\, nuclei or blood capillaries. This information was then used to analyze the internal organization of the tissue using unsupervised learning methods. This work opens the way to a better understanding of tumor architecture\, and ultimately aims to improve diagnosis\, choose the best treatment and better care for children with cancer.     \n  \nJury members: \nMs Karin PERNET GALLAY\, Research Engineer\, University of Grenoble Alpes\, Rapporteur\nM. Charles KERVRANN\, Directeur de Recherche\, Université de Rennes\, Rapporteur\nMrs. Nataliya SOKOLOVSKA\, Professor\, Sorbonne University\, Examiner\nMs Christèle ETCHEGARAY\, Research Fellow\, University of Bordeaux\, Examiner\nM. Baudouin DENIS DE SENNEVILLE\, Directeur de Recherche\, Université de Bordeaux\, Directeur\nM. Christophe F. GROSSET\, Directeur de Recherche\, Université de Bordeaux\, Co-Directeur
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-florian-robert/
LOCATION:salle des Actes bâtiment A33 campus Sciences et Technologies\, Talence
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/08/soutenance-de-these-florian-robert.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250925
DTEND;VALUE=DATE:20250927
DTSTAMP:20250602T104611Z
CREATED:20250602T104611Z
LAST-MODIFIED:20250602T104611Z
UID:49525-1758758400-1758931199@www.bricbordeaux.com
SUMMARY:Symposium “Microenvironment and Immunotherapy of Sarcomas”
DESCRIPTION:The BRIC is pleased to share the announcement of the 3rd International Symposium on Sarcomas\, organized as part of the RHU CONDOR program\, to be held on September 25–26\, 2025\, in Bordeaux. \nThis year’s symposium\, titled “Microenvironment and Immunotherapy of Sarcomas”\, will bring together international researchers\, clinicians\, and experts to address key challenges in the study of connective tissue tumors. Special focus will be placed on immunotherapy and the tumor microenvironment — two central pillars of current therapeutic strategies.  \nThe event is organized by the CONDOR program\, a national Hospital-University Research (RHU) project led by Antoine Italiano\, oncology researcher\, clinical oncologist\, and head of Team 9 “SarcoTarget” at the BRIC. His team\, in collaboration with Institut Bergonié\, specializes in developing new therapeutic approaches for sarcomas\, which are rare and complex cancers.  \nThis symposium will be a unique opportunity to highlight the latest scientific breakthroughs and strengthen collaboration within the global sarcoma research community. \n\n\nRegistration deadline: September 11\, 2025 \n\n\nRegistration and full program: https://condorprogram.com/symposium-3rd-edition \n\n\n\n\nWe strongly encourage you to register early to take part in these two days of rich scientific and clinical exchange.
URL:https://www.bricbordeaux.com/en/event/symposium-microenvironment-and-immunotherapy-of-sarcomas/
LOCATION:Agora du Haut Carré – Université de Bordeaux\, 43 rue Pierre Noailles\, Talence\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/06/design-sans-titre.jpg
ORGANIZER;CN="RHU Condor":MAILTO:contact@condorprogram.com
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250924T140000
DTEND;TZID=Europe/Paris:20250924T170000
DTSTAMP:20250918T151552Z
CREATED:20250918T151552Z
LAST-MODIFIED:20250918T151552Z
UID:50028-1758722400-1758733200@www.bricbordeaux.com
SUMMARY:HDR thesis defense by Delphine Fessart
DESCRIPTION:Delphine Fessart\, team 2.2 Oncology & Gynecology Laboratory (OncoGyne)\, will defend her Habilitation à Diriger des Recherches (HDR) on Wednesday\, September 24\, at 2:00 p.m.\, in the Conference Room (R+7) of the Bergonié Institute. \nTitle : « Décrypter les mécanismes moléculaires conduisant au développement tumoral ».
URL:https://www.bricbordeaux.com/en/event/hdr-thesis-defense-by-delphine-fessart/
LOCATION:Institut Bergonié\, 229 Cours de l'Argonne\, Bordeaux\, 33076\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/09/soutenance-hdr-delphine-fessart.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250923T133000
DTEND;TZID=Europe/Paris:20250923T170000
DTSTAMP:20250918T145053Z
CREATED:20250918T143354Z
LAST-MODIFIED:20250918T145053Z
UID:50017-1758634200-1758646800@www.bricbordeaux.com
SUMMARY:Thesis defense by Ruxue JIA
DESCRIPTION:Ruxue JIA will publicly defend her doctoral thesis in Cancer Biology\, supervised by Armelle MENARD\, Team 4: Digestive cancers associated with Helicobacter infection\, cancer stem cells\, and therapeutic strategies. \nTitle : Etude des voies de signalisation cellulaire modulées par les génotoxines bactériennes \nDefense scheduled for Tuesday\, September 23\, 2025\, at 1:30 p.m.\nAmphi 7\, Université de Bordeaux\, Campus Carreire\, 146 rue Leo Saignat 33000 Bordeaux \nNotice of defense with abstract available at this link (error in the notice)
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-ruxue-jia/
LOCATION:salles Nord et Sud – RDC Bâtimenet Bordeaux Biologie Santé (BBS)\, 2 rue du Dr Hoffmann Martinot\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/09/soutenance-de-these-ruxue-jia-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20250922
DTEND;VALUE=DATE:20251011
DTSTAMP:20250918T160613Z
CREATED:20250522T104742Z
LAST-MODIFIED:20250918T160613Z
UID:49403-1758499200-1760140799@www.bricbordeaux.com
SUMMARY:Cancer Neuroscience School - Bordeaux - 09/22 to 10/02
DESCRIPTION:Antonio C. Pagano Zottola\, Junior Professor Team 1 – Tumor and Vascular Biology Laboratory of our unit is co-organizing a Cancer Neuroscience School in Bordeaux from September 22 to October 10\, 2025. with Anna Golebiewska\, Luxembourg Institute of Health et Varun Venkataramani\, German Cancer Research Center. \n  \nThis 3-week training course is aimed at scientists at Master 2 level and above. \n  \nProgram of seminars open to the scientific community \n  \nThe Bordeaux Neuroscience School is part of Bordeaux Neurocampus\, the neuroscience department of the University of Bordeaux. The school operates on the principle that training in neuroscience and oncology research involves hands-on experimentation in a real research laboratory. A number of renowned speakers in neuro-oncology will be taking part in the course.  \nWhat to expect? \n\nHands-on projects using cutting-edge technologies from neuroscience and oncology\,\nLectures by top scientists and a Brain Prize 2025 : Frank Winkler\,\nTechniques ranging from primary cultures and organoids to advanced imaging\,\nA collaborative\, interdisciplinary environment to boost your research skills.\n\n  \nFull details and registration \n  \nDeadline Extended: Apply by July 7th
URL:https://www.bricbordeaux.com/en/event/cancer-neuroscience-school-bordeaux-09-22-to-10-02/
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/05/cajal-school-cancer-neuroscience-2025-0910-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250909T110000
DTEND;TZID=Europe/Paris:20250909T120000
DTSTAMP:20250711T151927Z
CREATED:20250711T151927Z
LAST-MODIFIED:20250711T151927Z
UID:49733-1757415600-1757419200@www.bricbordeaux.com
SUMMARY:Invited seminar Gautier Follain - 09-09-2025
DESCRIPTION:The BRIC unit welcomes Gautier Follain for a seminar open to the scientific community. \n  \nGautier Follain\, PhD \nShared postdoctoral researcher between the laboratories of Pr. Johanna Ivaska (University of Turku) Dr. Guillaume Jacquemet (Åbo akademi)\, both located in Turku (Finland). \nDocent at the University of Turku\, Field of application: Biophysics of cancer. \n  \nDissecting the intravascular adhesion and extravasation of Pancreatic Ductal AdenoCarcinoma. \n📆 Tuesday\, September 9 11 a.m. \n📌 BBS conference room\, 2 rue Dr Hoffmann Martinot\, Bordeaux \n  \nAbstract. \nSolid tumor progression is a complex succession of events happening in different spaces and times in the body\, ultimately leading to the formation of life-threatening metastases. To colonize distant organs\, cancer cells are exploiting the circulatory networks as natural paths before stopping in small vessels and crossing the endothelial barrier. \nMy current research focuses on the steps of intravascular adhesion and extravasation (crossing of the vessel border) of pancreatic ductal adenocarcinoma (PDAC) cell lines. My main objectives are to decipher the mechanisms allowing the cells to break the endothelial barrier\, in an attempt to identify key factors and actors during the process. I work with microfluidic models to better reproduce the physiologic conditions of perfused vessels\, zebrafish embryos which are transparent and very rapidly develop a complex vascular system and murine models. All three are coupled with quantitative and high-resolution live imaging and to single cell characterization approaches (scRNAseq\,mass cytometry\,…). \nMy ongoing results support the idea that heterogeneity of cancer\, even among laboratory cell lines\, is driving different adhesion/extravasation routes that are dramatically understudied. My talk will give an overview of my postdoc projects. 1. FlowVision\, our deep-learning based image analysis framework\, allowing the dissection of the arrest to stabilisation of circulating PDAC and immune cells (Follain et al. BioRxiv 2024). 2. An unbiased enrichment-based screening for key actors of the intravascular adhesion step. 3. The discovery of a novel extravasation route used by PDAC cells. \n  \nBio. \nI did a PhD in life science in the lab. of Dr. Jacky Goetz (Strasbourg). I studied the role of blood flow forces on arrest\, adhesion and extravasation of circulating breast/mammary cells\, using multiple imaging modalities\, mostly applied to microfluidics and zebrafish embryos. I described endothelial remodeling around arrested tumor cells as an extravasation mechanism of cancer cells (Follain et al. Dev cell 2018). Our works demonstrated that not only size exclusion but also shear forces are biophysic parameters driving the metastatic spreading (Follain et al. NRC 2020).\nI moved to Turku as a shared postdoc between the well established Cell adhesion lab of J. Ivaska\, expert in integrin biology\, and the newly born lab of G. Jacquemet focusing on cellular protrusion and cell migration. I used similar models to study the metastatic cascade of pancreatic ductal adenocarcinoma. I added to my skill set deep-learning based image analysis (Follain et al. BioRxiv 2024)\, imaging techniques\, murine models and more. \nI am now looking for the next step of my career in France..!
URL:https://www.bricbordeaux.com/en/event/invited-seminar-gautier-follain-09-09-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/07/gautier-follain-2025-09-09.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250704T110000
DTEND;TZID=Europe/Paris:20250704T120000
DTSTAMP:20250522T081608Z
CREATED:20250522T081608Z
LAST-MODIFIED:20250522T081608Z
UID:49391-1751626800-1751630400@www.bricbordeaux.com
SUMMARY:Invited seminar - Adriano Sabino - 04-07-2025
DESCRIPTION:Pr Adriano Sabino is invited by Vanessa Desplat\, Team 10\, Normal and Leukemic Hematopoietic Stem Cells. \nTitle: Omics Sciences Applied to the Investigation of Potential Biomarkers and Therapeutic Targets in Acute Leukemias \nPresenter: Prof. Adriano de Paula Sabino – Federal University of Minas Gerais (UFMG)\, Brazil  \nBio: Associate Professor at the Federal University of Minas Gerais (UFMG)\, Brazil. Holds a Ph.D. in Pharmaceutical Sciences with postdoctoral training in cancer therapy resistance at Michigan State University. Academic and research expertise in Clinical\, Experimental\, and Molecular Hematology. Research interests encompass cancer biology\, acute and chronic leukemias\, chemotherapy resistance\, molecular and cellular biomarkers\, functional genomics\, proteomics\, metabolomics\, nanobiomaterials\, regenerative medicine\, cell-based therapies\, and the application of bioinformatics to precision medicine.     \nAbstract: \nAcute leukemias\, including Acute Lymphoblastic Leukemia (ALL) and Acute Myeloid Leukemia (AML)\, are aggressive hematologic malignancies with high biological heterogeneity and limited predictive tools for therapeutic response and disease progression. In this context\, omics sciences offer powerful strategies to unravel the molecular complexity underlying these diseases and support the identification of new biomarkers and therapeutic targets.  \nThis seminar will provide an overview of our translational research efforts combining metabolomics\, clinical peptidomics\, and machine learning. We will discuss the conceptual and methodological foundations for applying mass spectrometry-based omics approaches (LC-MS and MALDI-TOF/MS) to plasma samples\, as well as the integration of artificial intelligence algorithms to enhance biomarker discovery\, risk stratification\, and individualized therapeutic guidance.  \nAdditionally\, we present the rationale and design of predictive modeling studies employing clinical and genomic datasets from AML patients. These models\, based on supervised learning techniques\, aim to improve the accuracy of outcome prediction and inform precision oncology strategies.  \nOur interdisciplinary approach highlights the potential of integrating systems biology\, data science\, and clinical research to advance personalized medicine in oncohematology. \nKeywords: Acute leukemia\, ALL\, AML\, biomarkers\, omics sciences\, LC-MS\, MALDI-TOF/MS\, machine learning\, precision oncology\, clinical stratification. \n📆 Friday 04-07\, 11am \n📌 BBS conference room\, 2 rue Dr Hoffmann Martinot Bordeaux
URL:https://www.bricbordeaux.com/en/event/invited-seminar-adriano-sabino-04-07-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/05/seminar-adriano-sabino-2025-07-13.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250702T100000
DTEND;TZID=Europe/Paris:20250702T130000
DTSTAMP:20250627T075338Z
CREATED:20250602T095142Z
LAST-MODIFIED:20250627T075338Z
UID:49523-1751450400-1751461200@www.bricbordeaux.com
SUMMARY:HDR Defense – Thomas MATHIVET
DESCRIPTION:HDR Defense (Accreditation to Supervise Research) in Life and Health Sciences \nThomas Mathivet Team 01 – Tumor and Vascular Biology Laboratory \n“Les molécules de guidage : de l’angiogenèse à la dynamique stromale et à l’invasion des tumeurs cérébrales” \nWednesday\, July 2\, 2025 at 10:00 AM \nBBS Amphitheater\, 2 rue Dr H. Martinot\, Bordeaux (Carreire Campus) \nJury \n➢ M Eric CHEVET\, Directeur de recherche\, Biosit\, INSERM – Rapporteur\n➢ Mme Barbara GARMY-SUSINI\, Directrice de recherche\, I2MC\, INSERM – Rapporteure\n➢ Mme Anna-Rita CANTELMO\, Chargée de recherche\, Université de Lille – Rapporteure\n➢ M François MOISAN\, Docteur\, Université de Bordeaux – Examinateur\n➢ M Andreas BIKALVI\, Professeur des universités\, Université de Bordeaux – Examinateur
URL:https://www.bricbordeaux.com/en/event/hdr-defense-thomas-mathivet/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/06/soutenance-hdr-thomas-mathivet-1.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250630T110000
DTEND;TZID=Europe/Paris:20250630T120000
DTSTAMP:20250617T140511Z
CREATED:20250617T140511Z
LAST-MODIFIED:20250617T140511Z
UID:49572-1751281200-1751284800@www.bricbordeaux.com
SUMMARY:Invited seminar - Jean-François Côté - 30-06-2025
DESCRIPTION:BRIC Team 3\, Liver Cancers and Tumor Invasion\, co-directed by Violaine Moreau and Frederic Saltel\, is pleased to invite Jean-François Côté\, President and Scientific Director of the Institut de recherches cliniques de Montréal (IRCM)\, Canada\, to present a seminar open to the scientific community.\nJean-François Côté is co-supervisor of Mélissa Correia De Oliveira‘s thesis\, team 3 BRIC. \n\nTitle : Mechanistic Insights into Tumour Growth\, Metastasis\, and Dormancy in Cancer Progression.\n\n\nAbstract\n\nMetastasis is the primary cause of cancer-related deaths\, yet the biological processes that enable tumor cells to spread\, survive in distant organs\, and eventually form secondary tumors remain incompletely understood. Gaining insight into these mechanisms is essential for developing strategies to prevent and treat metastatic disease across cancer types. \nIn the first part of my presentation\, I will discuss tumour dormancy in breast cancer. To uncover regulators of dormancy\, genome-wide CRISPR screens were performed on two breast cancer cell lines: 4T1 (short dormancy) and 4T07 (prolonged dormancy). 4T07 cells uniquely depended on class III PI3K (PIK3C3) and showed elevated mTORC1 activity via peripheral lysosome signaling. Inhibiting PIK3C3 suppressed this activity in both mouse and human models\, reduced metastasis in 4T07\, and eliminated dormant cells in a HER2-driven model. These results highlight PIK3C3-mTORC1 signaling as a potential therapeutic target to prevent metastatic relapse. In the second part of the presentation\, I will focus on RAS family proteins that regulates key signaling pathways involved in cell growth\, differentiation\, and survival. While canonical RAS proteins are well studied\, the broader group of 35 human RAS-related GTPases remains largely unexplored. Using proximity-dependent biotinylation (BioID) in three cell models\, we mapped interaction networks and subcellular localizations across the family. This generated a high-confidence interactome\, revealing thousands of spatially resolved associations. By analyzing nucleotide-state-specific variants\, we identified context-dependent interactions with effectors and regulators. Comparative clustering highlighted conserved and unique features across subfamilies. Integration with DepMap data uncovered essential crosstalk with regulators Rho GTPases and cytoskeletal dynamics in canonical RAS proteins. This resource advances our understanding of RAS-family signaling and its roles in development\, disease\, and cancer.            \n\n\n📆 Monday\, June 30\, 2025\, 11 a.m.\n📌 Conference room BBS (Bordeaux\, Biologie\, Santé)\,\n2 rue dr Hoffmann Martinot\, Bordeaux. Université de Bordeaux\, site Carreire
URL:https://www.bricbordeaux.com/en/event/invited-seminar-jean-francois-cote-30-06-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250612T101500
DTEND;TZID=Europe/Paris:20250612T111500
DTSTAMP:20250523T091324Z
CREATED:20250407T123707Z
LAST-MODIFIED:20250523T091324Z
UID:49045-1749723300-1749726900@www.bricbordeaux.com
SUMMARY:Invited seminar - Romain PARENT - 12-06-2025
DESCRIPTION:Invited seminar by team 6 MIRCADE (Methods and Innovations for the Research in Pediatric Cancers.) headed by Christophe Grosset. \nRomain PARENT\nHepatitis Viruses & Liver Pathogenesis (PathLiv) Laboratory – UMR 1350\nInserm – Claude Bernard Lyon 1 University – Lyon Hepatology Institute \nThe interest of liver innervation in chronic liver disease and liver cancer. \nAbstract\nHepatocellular carcinoma (HCC) care has long been hampered by the enigmatic nature of disease onset across patients\, evolution\, as well as of response or resistance to treatment. Hepatic neural cells are likely the least studied liver cell type and mediate patients singularities from the ANS to the organ in real-time. These cells\, belonging to the autonomic nervous system (ANS)\, mediate liver/whole body crosstalk. Pathological innervation of the ANS has been identified in cancer\, nurturing tumor stroma and conferring stronger carcinogenic properties.\nIn this presentation focusing on a pathogenic continuum between normal liver and HCC\, we will present evidence for: (i) deep alterations of neural markers along this spectrum\, (ii) the presence of neural pools of cells in lesions\, (iii) the introduction of a novel neuronal score-based approach for stratification with respect to pathological and immunological considerations\, and (iv) functional studies causally demonstrating the interest of these notions for rational and accessible therapeutic intervention.     \n  \nBiography\nI obtained a PharmD at the U. of Aix-Marseille 1 in 2001 and a PhD in hepatic virology in 2004 through a PhD exchange program between the Center for the Study of Hepatitis C at the Rockefeller University of New-York and the Inserm Unit 271 in Lyon\, working on the early HCV tissue culture systems.\nI then spent four years at the Fred Hutchinson Cancer Research Center in Seattle working on HCV virology and cell translation. I obtained an Inserm CR2 position in 2009.\nI have been till then leading an independent group within Fabien Zoulim’s PathLiv laboratory\, gradually evolving from translational virology towards the study of liver innervation in pathology\, through a long term work on the axonal guidance cue netrin-1.\nMy group’s work on netrin-1 have ended up in the Phase III HCC-NET1 clinical trial which has for goal to target the axonal guidance factor netrin-1 in HCC. I recently obtained a Master degree in philosophy. As a teaching unit head at the Oncology Master of Lyon 1\, I also tackle these issues through the mind-body philosophical paradigm with the students.   \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-romain-parent-12-06-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250514T150000
DTEND;TZID=Europe/Paris:20250514T160000
DTSTAMP:20250428T092433Z
CREATED:20250428T092433Z
LAST-MODIFIED:20250428T092433Z
UID:49248-1747234800-1747238400@www.bricbordeaux.com
SUMMARY:Invited seminar - Thomas Bertero - 14-05-2025
DESCRIPTION:Invited seminar by Violaine Moreau\, Team 3\, Liver Cancers and Tumor Invasion and Isabelle Sagot\, Quiessence and Multicellularity Team\, IBGC \nThomas Bertero is CRCN CNRS\, CNRS Bronze Medal 2019. He studies the link between the mechanical response of cells to their environment and metabolism.\nInstitut de Pharmacologie moléculaire et cellulaire (IPMC)\nUniversité Côte d’Azur/CNRS/Inserm\nValbonne \nTitle: Mechano-metabolism: From tissues to molecules\n\nAbstract :\nThe spatiotemporal control of cell behaviour requires the transmission of information from the complex structure of tissues to their constituent cells. Mechanotransduction enables this transmission by sensing mechanical environments and adapting cellular behaviours. However\, this process requires energy. Since our pioneering study demonstrating a link between cell mechanics and cell metabolism (Bertero et al\, J Clin Invest 2016) our laboratory has been interested in deciphering how tissue mechanical properties shape – and are shaped by – cell metabolism. Here\, I will summarise our recent discoveries on how the mechanical properties of the tumour niche reprogram glutamine and glucose metabolism to promote breast cancer progression.    \n📆 Wednesday\, May 14\, 3pm\n📌 Amphi BBS (Bordeaux Biologie Santé) 2 rue du Dr Hoffmann Martinot \nSelected publications:\nMechano-dependent sorbitol accumulation supports biomolecular condensate. \nTorrino S\, Oldham WM\, Tejedor AR\, Burgos IS\, Nasr L\, Rachedi N\, Fraissard K\, Chauvet C\, Sbai C\, O’Hara BP\, Abélanet S\, Brau F\, Favard C\, Clavel S\, Collepardo-Guevara R\, Espinosa JR\, Ben-Sahra I\, Bertero T. Cell. 2025 Jan 23;188(2):447-464.e20. doi: 10.1016/j.cell.2024.10.048.   \n\n \nSystems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension. \nBertero T\, Lu Y\, Annis S\, Hale A\, Bhat B\, Saggar R\, Saggar R\, Wallace WD\, Ross DJ\, Vargas SO\, Graham BB\, Kumar R\, Black SM\, Fratz S\, Fineman JR\, West JD\, Haley KJ\, Waxman AB\, Chau BN\, Cottrill KA\, Chan SY. J Clin Invest. 2022 May 16;132(10):e161077. doi: 10.1172/JCI161077.  \n\n \n\n\nMetabo-reciprocity in cell mechanics: feeling the demands/feeding the demand. \nTorrino S\, Bertero T. Trends Cell Biol. 2022 Jul;32(7):624-636. doi: 10.1016/j.tcb.2022.01.013. Epub 2022 Feb 14.   \n \nMechano-induced cell metabolism promotes microtubule glutamylation to force metastasis. \nTorrino S\, Grasset EM\, Audebert S\, Belhadj I\, Lacoux C\, Haynes M\, Pisano S\, Abélanet S\, Brau F\, Chan SY\, Mari B\, Oldham WM\, Ewald AJ\, Bertero T. Cell Metab. 2021 Jul 6;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009.  \n \n\n\nTumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy. \nBertero T\, Oldham WM\, Grasset EM\, Bourget I\, Boulter E\, Pisano S\, Hofman P\, Bellvert F\, Meneguzzi G\, Bulavin DV\, Estrach S\, Feral CC\, Chan SY\, Bozec A\, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012.  \n \nVascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension. \nBertero T\, Oldham WM\, Cottrill KA\, Pisano S\, Vanderpool RR\, Yu Q\, Zhao J\, Tai Y\, Tang Y\, Zhang YY\, Rehman S\, Sugahara M\, Qi Z\, Gorcsan J 3rd\, Vargas SO\, Saggar R\, Saggar R\, Wallace WD\, Ross DJ\, Haley KJ\, Waxman AB\, Parikh VN\, De Marco T\, Hsue PY\, Morris A\, Simon MA\, Norris KA\, Gaggioli C\, Loscalzo J\, Fessel J\, Chan SY. J Clin Invest. 2016 Sep 1;126(9):3313-35. doi: 10.1172/JCI86387.
URL:https://www.bricbordeaux.com/en/event/invited-seminar-thomas-bertero-14-05-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/04/thomas-bertero-2025-05-14.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20250513T093000
DTEND;TZID=Europe/Paris:20250513T103000
DTSTAMP:20250428T133528Z
CREATED:20250428T133528Z
LAST-MODIFIED:20250428T133528Z
UID:49259-1747128600-1747132200@www.bricbordeaux.com
SUMMARY:Invited Seminar - Bruno Segui - 13-05-2025
DESCRIPTION:Pr. Bruno Segui \, invited by Majid Khatib\, team 2 Reprograming tumor activitY and associaTed MicroenvironmEnt (Rytme).\nCo-head of the team MELASPHINX: Ceramide metabolism in melanoma: from basic mechanisms to immunotherapy in the Toulouse Cancer Research Center (CRCT) \nTitle : TNF blockade with certolizumab\, but not infliximab\, improves efficacy of anti-PD-1 and anti-CTLA-4 combination in melanoma \n  \nAbstract \nThe combination of anti-PD-1 and anti-CTLA-4 boosts the anti-cancer immune response in patients with advanced melanoma. However\, 60% of patients fail to respond or relapse early after induction\, and 95% develop immune-related adverse events (irAEs) such as colitis\, which can be treated with infliximab\, a tumour necrosis factor-alpha inhibitor (TNFi). The impact of TNFi on immune and clinical responses remains to be elucidated. Here we provide evidence that TNF blockade can improve the response to the anti-PD-1 and anti-CTLA-4 combination not only in mice but also in patients enrolled in a phase 1b clinical trial (TICIMEL\, NTC03293784). However\, certolizumab\, but not infliximab\, strongly stimulates immune and therapeutic responses to ICI. Mechanistically\, we have shown that the IgG1 Fc fragment of infliximab impairs the ability of TNF blockade to stimulate the efficacy of ICI therapy. When combined with ICI\, certolizumab decreased the proportion of regulatory T cells (Tregs) and exhausted T cells\, while increasing the proportion of effector T cells in tumors as assessed by single-cell RNA sequencing and spectral flow cytometry. In conclusion\, our study shows that TNF impairs the immune response to melanoma and that the type of TNFi must be well selected to improve the efficacy of ICI in melanoma.        \n  \n📆 Tuesday\, May 13 9:30 a.m.\n📌 Amphi BBS (Bordeaux Biologie Santé) 2 rue du Dr Hoffmann Martinot \n  \nBruno Ségui  \nCV overview: \n2000: PhD in human pathophysiology (Toulouse University). \n2000-2002: Postdoctoral position (University College London\, UK). \n2006: HDR (Toulouse University). \n2002-2011: Assistant Professor of Immunology\, Faculty of Pharmacy (Toulouse III). \nSince 2011: Professor of Cell Biology\, Faculty of Pharmacy (Toulouse III). \nResearch activity in the Cancer Research Center of Toulouse (CRCT). \nSince 2019: Deputy Director of the CARe graduate school on Cancer Aging and Rejuvenation. \nSince 2021: Team leader of MELASPHINX at the Cancer Research Center of Toulouse\, \nco-PI: Dr. N. Andrieu-Abadie.  \n  \nOverview of research activities: \nOver the last 25 years\, I have been studying the signalling pathways triggered by some members of the TNF receptor superfamily\, including CD40\, Fas/CD95 and TNFR1/CD120a. In this context\, we have highlighted the role of sphingolipids in the modulation of both apoptosis and immune responses (Ségui et al.\, J. Biol. Chem.\, 1999; Ségui et al\, J. Clin. Invest. 2001; Montfort et al.\, J. Immunol. 2009; Lafont et al.\, Cell Death Differ. 2010). More recently\, we have shown that TNF blockade enhances the CD8 T cell-dependent immune response (Bertrand et al.\, Cancer Res. 2015) and overcomes the resistance to anti-PD-1 (Bertrand et al.\, Nat. Commun. 2017) in mouse melanoma models. Mechanistically\, TNF triggers the activation-induced cell death of CD8+ tumour-infiltrating lymphocytes. We have translated our concept into the clinic in advanced melanoma patients\, where we have shown that two triple therapies combining TNF blockers (infliximab or certolizumab) with anti-PD-1 (nivolumab) and anti-CTLA-4 (certolizumab) are safe for patients\, with promising signs of efficacy in the certolizumab cohort (Montfort et al.\, Clin. Cancer Res 2021). Moreover\, Elevated plasma TNF and enriched TNF pathways in T cells are associated with poorer clinical outcome in patients with advanced melanoma\, reinforcing the notion that TNF may dampen the efficacy of immune checkpoint inhibitors (Virazels et al.\, Int J Cancer\, in press).      \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-bruno-segui-13-05-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://www.bricbordeaux.com/wp-content/uploads/2025/04/seminar-bruno-segui-2025-05-13.jpg
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