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X-WR-CALDESC:Events for Bordeaux Institute of Oncology
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260605T140000
DTEND;TZID=Europe/Paris:20260605T170000
DTSTAMP:20260527T085102Z
CREATED:20260520T093617Z
LAST-MODIFIED:20260527T085102Z
UID:51696-1780668000-1780678800@www.bricbordeaux.com
SUMMARY:Thesis Defense Cloé Tessier
DESCRIPTION:Ph.D. thesis in Cancer Biology \nCloé Tessier\, team 1 BRAINSTRIM Brain tumor stroma\, resistance\, invasion and metabolism \nThesis supervision Lucie Brisson \nCaractérisation et rôle du catabolisme des gouttelettes lipidiques dans le glioblastome. \nFriday\, June 5\, 2:00 p.m. \nConference room IECB\, 2 Rue Robert Escarpit\, 33600 Pessac \n  \nNotice of thesis defense with abstract \n  \nWatch the video of Cloé Tessier (in French)\, recorded in July 2023\, in which she presents her team’s research topic in 180 seconds: finding new treatments for glioblastoma. \n  \n[vc_video link=’https://www.youtube.com/watch?v=4nAVOcMItck’]
URL:https://www.bricbordeaux.com/en/event/thesis-defense-cloe-tessier/
LOCATION:Amphithéatre de l’IECB\, 2 rue Robert Escarpit\, Pessac\, 33600\, France
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/05/soutenance-de-these-cloe-teissier-team-1-bric.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260623T140000
DTEND;TZID=Europe/Paris:20260623T170000
DTSTAMP:20260616T133839Z
CREATED:20260608T094824Z
LAST-MODIFIED:20260616T133839Z
UID:51863-1782223200-1782234000@www.bricbordeaux.com
SUMMARY:Thesis Defense Nasir ABBASI - 23-06-2026
DESCRIPTION:Ph.D. thesis in Cancer Biology by Nasir ABBASI\, Team 5.1 \nJoint supervision of the thesis by Audrey GROS (BRIC) and Slim KARKAR (IBGC) \nA Study of Tumor Heterogeneity in Sézary Syndrome Using Bioinformatics Approaches. (Presentation in French) \nTuesday\, June 23\, 2:00 p.m. \nCARF Conference Room (ex CGFB)\n146 Rue Léo Saignat\, 33000 Bordeaux \n  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-nasir-abbasi-23-06-2026/
LOCATION:CARF (ex CGFB)\, 146 rue Léo Saignat\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-nasir-abbasi-bric-team-5.1-23-06-2026-3.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260625T090000
DTEND;TZID=Europe/Paris:20260625T170000
DTSTAMP:20260624T125513Z
CREATED:20260617T080154Z
LAST-MODIFIED:20260624T125513Z
UID:51941-1782378000-1782406800@www.bricbordeaux.com
SUMMARY:Thesis Defense by Mathieu Bourgeais\, Team 2 BRIC & CBMN
DESCRIPTION:Organic Chemistry Thesis Defense: Mathieu Bourgeais\, team 2.1 \nThesis Title: \nSynthesis and Evaluation of Peptide Compounds for the Targeted Degradation of Oncoproteins (french presentation) \nThesis advisors: \nAbdel-Majid Khatib (BRIC team 2.1) et Gilles Guichard (IECB\, CBMN\, UMR 5248) \nDate and time of the defense: \nJune 25\, 2026\, 9 a.m. \n  \nLocation: \nConference room IECB\, 2 Rue Robert Escarpit\, 33600 Pessac \nVideo conference link: \nhttps://sanofi.zoom.us/j/99771203256?pwd=mNK7Iih0btybyAtw0oALnn3dA91D49.1&from=addon \nAbstract: \nThis thesis focuses on the design\, synthesis\, and evaluation of innovative peptide and peptidomimetic compounds intended for the modulation and targeted degradation of oncoproteins. Due to their selectivity and modularity\, peptides serve as ideal platforms for targeting hard-to-reach protein-protein interfaces and for exploiting endogenous cellular degradation mechanisms. In this context\, two main targets were explored: hDM2\, for its E3 ligase activity and its interaction with the tumor suppressor p53\, and furin\, a proprotein convertase involved in tumor progression.   \nIn the first phase\, constrained ligands mimicking the natural p53 helix were developed as peptide-foldamer hybrids incorporating oligourea segments and macrocyclization patterns derived from structures co-crystallized with hDM2. The exploitation of new cyclization opportunities that stabilize the original alpha-helix—notably through the introduction of cysteines and a mercaptoprolin residue—enabled the stiffening of compounds exhibiting high affinity for hDM2/hDMX. Careful sequence tuning also revealed that polycationic segments induced p53-independent cytotoxicity\, whereas macrocyclic peptide-foldamer hybrids with a net neutral charge restored p53’s antitumor activity in p53wt cancer cells. These optimized ligands thus constitute high-affinity\, stable\, and permeable modules suitable for subsequent integration into architectures that utilize hDM2 as a target or E3 ligase in the development of PROTAC-type peptidomimetic degraders.    \nIn a second phase\, a robust synthetic route for furin peptide inhibitors was established\, enabling the development of analogs active against the recombinant enzyme and in cellular environments. These ligands were then used as a basis for exploring targeted degradation strategies\, including hydrophobic tagging\, PROTACs targeting the Cereblon or von Hippel-Lindau E3 ligases\, and LYTACs targeting internalizing receptors. The results highlight the potential of these approaches while underscoring the constraints imposed by furin’s membrane localization and luminal orientation\, which limit the efficacy of certain degradation modalities.   \nTaken together\, these studies demonstrate that peptidomimetic engineering\, combined with macrocyclization strategies\, represents a promising approach for generating new bifunctional tools capable of selectively degrading oncoproteins. These advances open up new possibilities for the development of next-generation degraders targeting both intracellular and extracellular targets\, demonstrating that such architectures can be rationally optimized to ensure high affinity\, increased stability\, and the ability to direct proteins to proteasomal or lysosomal degradation pathways.  \n  \nNotice of Thesis Defense
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-mathieu-bourgeais-team-2-bric-cbmn/
LOCATION:Amphithéatre de l’IECB\, 2 rue Robert Escarpit\, Pessac\, 33600\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-mathieu-bourgeais-bric-team-2-25-06-2026.jpg
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DTSTART;TZID=Europe/Paris:20260630T133000
DTEND;TZID=Europe/Paris:20260630T170000
DTSTAMP:20260629T125334Z
CREATED:20260622T154125Z
LAST-MODIFIED:20260629T125334Z
UID:51969-1782826200-1782838800@www.bricbordeaux.com
SUMMARY:Arthur Poulet's Thesis Defense\, June 30\, 2026
DESCRIPTION:Arthur Poulet‘s thesis Defense\, team 10 \nThesis Advisor Amélie Guitart \nSpecialty: Cell Biology and Pathophysiology \nRégulation de l’expansion des cellules souches hématopoïétiques \nTuesday\, June 30\, 2026\, 1:30 p.m. \nAmphi B Odontologie\nRue Hoffmann-Martinot\, 33000\, Bordeaux \n  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/arthur-poulets-thesis-defense-june-30-2026/
LOCATION:Amphi B\, faculté Odontologie\, 146 rue Léo Saignat\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-arthur-poulet-team-10-30-06-2026-1.jpg
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