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DTSTART;TZID=Europe/Paris:20260713T150000
DTEND;TZID=Europe/Paris:20260713T190000
DTSTAMP:20260703T095129Z
CREATED:20260626T130345Z
LAST-MODIFIED:20260703T095129Z
UID:52018-1783954800-1783969200@www.bricbordeaux.com
SUMMARY:thesis defense Chloé Porcheron\, team 2.1
DESCRIPTION:Chloé Porcheron\, team 2.1 \nPhD specialty: Cancer biology. \nRôles de PCSK7 et PCSK9 dans la progression tumorale et la réponse immunitaire associée. \nJoint supervision Majid Khatib and Nabil Seidah (Director of the Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute – IRCM) \nJuly 13\, 2026\, at 3:00 p.m.\nLieu : Amphithéatre du BBS (bâtiment biologie santé) site Carreire Université de Bordeaux 2 rue Docteur Hoffmann Martinot\, Bordeaux et visio\n\n\nLien de visio - code secret 925758\n\n\n\n\nJury members: \n\nPERREAULT Claude\, Professeur\, Université de Montréal\, Président du Jury \nKHATIB A-Majid\, Directeur de recherche\, Université de Bordeaux\, Directeur de thèse \nSEIDAH Nabil G.\, Directeur de recherche\, Université de Montréal\, Directeur de thèse \nLALLOUÉ Fabrice\, Professeur\, Université de Limoges\, Rapporteur \nSEGUI Bruno\, Professeur\, Université de Toulouse\, Rapporteur \nTEICHMANN Martin\, Professeur\, Université de Bordeaux\, Examinateur \nMme. DUBOIS Claire\, Professeure\, Université de Sherbrooke\, Examinateur  \nMme. FONTES Ghislaine\, Associée de recherche\, Université de Mc Gill\, Examinatrice  \n\n \nSoutenance : \n\nJuly 13\, 2026\, at 3:00 p.m.\nLocation: BBS conference room\, Carreire Campus\, University of Bordeaux\n2 rue Docteur Hoffmann Martinot\, Bordeaux\n\nAbstract: \n\nLes proprotéines convertases (PCs) sont une famille de 9 sérines protéases sécrétoires reconnues pour le clivage de nombreux substrats pour leur maturation. Les PCs sont impliquées dans de nombreux processus physiologiques dus à la variabilité des substrats\, c’est pourquoi la dérégulation de leur expression ou de leur activité peut mener à diverses pathologies dont le cancer.\nBien que PCSK7 soit la convertase la plus ancienne de la famille des PCs\, son rôle physiologique reste très peu caractérisé. Ce n’est que récemment que PCSK7 a été associée au métabolisme des lipides par la régulation des niveaux de l’apoB et de l’apoA-V sans aucune activité protéolytique. Ce qui classe PCSK7\, comme le dernier membre PCSK9\, comme une PC possédant une fonction non enzymatique. PCSK7 est exprimée de façon ubiquitaire dans l’organisme\, cependant elle est retrouvée enrichie dans les organes lymphoïdes au niveau tissulaire et dans les cellules immunitaires\, plus particulièrement dans les lymphocytes T\, au niveau cellulaire. Malgré ces observations\, le rôle de PCSK7 dans la réponse immunitaire reste largement inconnu.\nAfin de définir un possible rôle de PCSK7 dans l’immunité\, nous nous sommes d’abord intéressés aux banques de données humaines pour étudier l’expression de PCSK7 parmi tous les facteurs responsables de la réponse immunitaire. Ces données ont mis en évidence une corrélation positive entre les niveaux d’expression des ARN codant pour PCSK7 et certains points de contrôle immunitaires\, qui sont des protéines de surface inhibitrices de la fonction des lymphocytes T. Nous avons ainsi étudié les niveaux d’expression des points de contrôle immunitaires au niveau intracellulaires et à la surface cellulaire en modulant l’expression de PCSK7 dans différents modèles in vitro tels qu’une lignée cellulaire d’hépatocytes humains\, des lymphocytes T murins isolés de la rate et des lymphocytes T humains provenant d’échantillons de sang de donneurs. Ainsi\, ces études ont démontré le rôle important de PCSK7 dans la régulation des niveaux des points de contrôle immunitaires.\nLes immunothérapies basées sur l’inhibition des points de contrôles immunitaires ont représenté une réelle avancée dans le traitement du cancer mais celles-ci restent peu efficaces pour une majorité de patients. C’est pourquoi nous avons étudié le possible rôle thérapeutique de l’inhibition de PCSK7 dans la progression tumorale\, seule ou en combinaison avec l’inhibition de PCSK9\, déjà reconnue comme un médiateur important de la réponse immunitaire antitumorale. Ainsi\, la délétion simple de Pcsk7 ou de Pcsk9 chez les souris permet une réduction du nombre de métastases hépatiques du cancer colorectal d’environ 50%\, tandis que la double délétion Pcsk7/Pcsk9 permet une réduction du développement métastatique d’environ 90%. En effet\, l’absence de Pcsk7 et de Pcsk9 favorise l’infiltration des lymphocytes T CD8+ dans les tumeurs hépatiques et réduit l’expression des points de contrôles immunitaires améliorant ainsi l’activité cytotoxique des lymphocytes T infiltrés.\nPour conclure\, cette étude décrit un nouveau rôle de PCSK7 dans l’immunité\, par la régulation des niveaux d’expression des points de contrôles immunitaires\, rationalisant ainsi l’utilisation d’inhibiteurs de PCSK7 dans les immunothérapies seules ou en combinaison avec un inhibiteur de PCSK9 dans le traitement du cancer.\n\nMots clés : \n\nproprotéine convertase subtilisine/kéxine type 7 (PCSK7)\, proprotéine convertase subtilisine/kéxine type 9 (PCSK9)\, réponse immunitaire antitumorale\, points de contrôles immunitaires\, métastases hépatiques\, lymphocytes T CD8+\n\n 
URL:https://www.bricbordeaux.com/en/event/thesis-defense-chloe-porcheron-team-2-1/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-chloe-porcheron-team-2.1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260709
DTEND;VALUE=DATE:20260711
DTSTAMP:20260707T123101Z
CREATED:20260320T132739Z
LAST-MODIFIED:20260707T123101Z
UID:51281-1783555200-1783727999@www.bricbordeaux.com
SUMMARY:ChemBioNA2026: 2026 Chemistry and Biology Conference in Nouvelle-Aquitaine
DESCRIPTION:The ChemBioNA network is hosting its second regional conference! \nVanessa Desplat (team 10) and Majid Khatib (team2) are members of the organizing committee. \nThis event is designed to serve as a forum for exchange and networking among professionals working in the fields of chemistry\, biology\, and their intersections. \nIt will take place on July 9 and 10 at the Domaine du Haut Carré on the University of Bordeaux campus in Talence. \nInformation and registration \nDeadlines: \n\nRegistration (free): 15/06/2026\nAbstract submission: 31/05/2026\n\n\n  \nInvited speakers: \n\nKevin Baranger (LIENSs – La Rochelle) : Title to be announced\nVanessa Desplat (BRIC – Bordeaux) : How to target FLT3 receptor mutations in acute myeloid leukemia ?\nMarion Girardot (EBI – Poitiers) : Title to be announced\nStéphanie Krisa (ISVV – Bordeaux) : Title to be announced\nElisabetta Leo (Ipsen – United Kingdom) : Title to be announced\nVincent Sol  (LABCiS – Limoges) : Title to be announced\nFabien Thoreau  (IC2MP – Poitiers) : Combination of metabolic glyco-engineering and disulfide rebridging for the grafting of antibody fragments on cell surface – toward new cell therapies\n\n  \nThe organising comitee: \nFrédéric CANTAGREL (CBMN-UMR5248)\nJean Philippe BORGES (Cancéropôle GSO)\nVanessa DESPLAT (BRIC-U1312)\nValérie DESVERGNES (ARNA – U1212/UMR5320)\nMajid KHATIB (BRIC-U1312)\nKarine MARENDZIAK (Cancéropôle GSO)\nMathieu METIFIOT (MFP-UMR5234)\nTristan RICHARD (OENO-UMR1366)
URL:https://www.bricbordeaux.com/en/event/chembiona2026-2026-chemistry-and-biology-conference-in-nouvelle-aquitaine/
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/03/chembiona2026-congres-de-chimie-biologie-en-nouvelle-aquitaine-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260706T114500
DTEND;TZID=Europe/Paris:20260706T130000
DTSTAMP:20260702T132900Z
CREATED:20260615T134418Z
LAST-MODIFIED:20260702T132900Z
UID:51921-1783338300-1783342800@www.bricbordeaux.com
SUMMARY:Invited seminar - Reini Luco - 06-07-2026
DESCRIPTION:Julie Giraud and BRIC team 3 invite Dr. Reini F. Luco  \, team leader of the Chromatin and RNA Splicing team in the Genome Integrity\, RNA\, and Cancer Unit (UMR3348 / U1368) at the Institut Curie\, to give a seminar open to the scientific community. \nA three-dimensional splicing organization important for cell invasiveness. \nMonday\, July 6\, 2026\, 11:45 a.m.\, BBS Conference Room. \nBiosketch \nDr. Luco’s scientific journey began at the Hospital Clinic of Barcelona\, where she completed her PhD in Jorge Ferrer’s lab\, investigating how histone modifications organize genes within nuclear space in the context of inherited diabetes. She then pursued postdoctoral research at the NIH in Tom Misteli’s lab\, where she contributed to pioneering work revealing that chromatin not only regulates DNA but also plays a key role in RNA splicing. In 2013\, she established her own research group at the Institut de Génétique Humaine in Montpellier\, where she expanded her work on how histone marks shape cell type–specific splicing programs through the development of innovative CRISPR-based epigenetic and RNA editing tools. Now based at the Institut Curie in Paris\, her group is exploring how this chromatin-mediated splicing regulation contributes to cancer cell invasiveness and the early steps of metastasis. \nAbstract \nMetastasis and treatment resistance remain the main causes of cancer-related mortality. A major challenge is to target aggressive cells early enough\, before their plasticity enables adaptation through EMT reprogramming. In this context\, the key issue is not only which genes are expressed\, but also how they are processed into different isoforms. Alternative splicing can rapidly rewire protein function without major transcriptional changes and has emerged as a critical regulatory layer in EMT and cancer progression. Indeed\, splicing signatures often outperform gene-expression patterns in identifying poor-prognosis cancers\, suggesting that isoform regulation may better capture the functional adaptations underlying aggressiveness. Yet it remains unclear how transcriptional and splicing programs are activated so rapidly and in a coordinated manner during EMT. We have previously shown that chromatin is a major regulator of splicing dynamics. Using CRISPR–dCas9 epigenome editing\, we demonstrated that exon-localized chromatin marks can drive EMT-associated splicing switches by modulating recruitment of the splicing factor PTBP1 to pre-mRNA. Using an adapted CRISPR genomic screen and antibody-based proximity labeling approaches\, we now propose that invasive reprogramming depends on a dynamic 3D chromatin organization that coordinates transcriptional and splicing regulation through specialized hubs. Distrubing these hubs could be an innovative strategy to target metastasis at its source.
URL:https://www.bricbordeaux.com/en/event/invited-seminar-reini-luco-06-07-2026/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/invited-seminar-reini-luco-06-07-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260703T131500
DTEND;TZID=Europe/Paris:20260703T170000
DTSTAMP:20260626T125007Z
CREATED:20260626T125007Z
LAST-MODIFIED:20260626T125007Z
UID:52009-1783084500-1783098000@www.bricbordeaux.com
SUMMARY:Thesis Defense by Anissa ZAAFOUR\, Team 4
DESCRIPTION:Thesis Defense by Anissa ZAAFOUR\, tteam 04 – Helicobacter-associated digestive cancers\, cancer stem cells and therapeutic strategies. \nThesis Supervision Christine Varon \nSpecialization: Cancer Biology \n“Caractérisation et ciblage des cellules souches cancéreuses dans le cancer gastrique : vers de nouvelles pistes diagnostiques et\nthérapeutiques” \nFriday\, July 3\, 1:15 p.m.\, BBS conference room
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-anissa-zaafour-team-4/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-anissa-zaafour-team-4-03-07-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260703
DTEND;VALUE=DATE:20260704
DTSTAMP:20260407T144030Z
CREATED:20260403T115123Z
LAST-MODIFIED:20260407T144030Z
UID:51411-1783036800-1783123199@www.bricbordeaux.com
SUMMARY:360° Symposium - The Skin at the Crossroads of Science - Poitiers - July 3\, 2026
DESCRIPTION:Muriel Cario\, (team5 and Aquiderm) is part of the organizing committee for this symposium on skin\, which will take place in Poitiers on July 3\, 2026\, as part of the multidisciplinary conference of the Regional Research Network on Reconstructed and Reconstructed Human Health (HR2S) – “360° Health” (July 1–3 in Poitiers). \nThe Skin at the Crossroads of Science: Integrated Approaches and New Research Models\nThis symposium aims to explore the synergies between basic and translational research and clinical innovations in order to address the clinical and molecular heterogeneity of inflammatory and genetic skin diseases. \nFor more details and to submit papers by April 13\, 2026\, visit this website: \n  \nConference website\n 
URL:https://www.bricbordeaux.com/en/event/360-symposium-the-skin-at-the-crossroads-of-science-poitiers-july-3-2026/
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/04/congres-peau-au-carrefour-des-sciences-03-07-2026-poitiers-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260630T133000
DTEND;TZID=Europe/Paris:20260630T170000
DTSTAMP:20260629T125334Z
CREATED:20260622T154125Z
LAST-MODIFIED:20260629T125334Z
UID:51969-1782826200-1782838800@www.bricbordeaux.com
SUMMARY:Arthur Poulet's Thesis Defense\, June 30\, 2026
DESCRIPTION:Arthur Poulet‘s thesis Defense\, team 10 \nThesis Advisor Amélie Guitart \nSpecialty: Cell Biology and Pathophysiology \nRégulation de l’expansion des cellules souches hématopoïétiques \nTuesday\, June 30\, 2026\, 1:30 p.m. \nAmphi B Odontologie\nRue Hoffmann-Martinot\, 33000\, Bordeaux \n  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/arthur-poulets-thesis-defense-june-30-2026/
LOCATION:Amphi B\, faculté Odontologie\, 146 rue Léo Saignat\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-arthur-poulet-team-10-30-06-2026-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260625T130000
DTEND;TZID=Europe/Paris:20260625T140000
DTSTAMP:20260624T120448Z
CREATED:20260624T115710Z
LAST-MODIFIED:20260624T120448Z
UID:51986-1782392400-1782396000@www.bricbordeaux.com
SUMMARY:Techno seminar Explicyte - BRIC invitation
DESCRIPTION:For our latest internal seminar\, we are opening the doors of the auditorium to the company Explicyte. \n“We are a specialty contract research organization offering research services in precision oncology & immuno-oncology. Based in France\, we have assisted international biotech\, AI\, and pharma companies\, as well as comprehensive cancer centers for the past 10 years.” \n  \nExplicyte to BRIC\n  \n\n\n\nTitle : Translational CRO expertise to unlock your samples at single-cell resolution. \n\n\n\n\nOrators : Jean-Philippe Guegan (CTO\, jp.guegan@explicyte.com) et Alban Bessede (CEO\, a.bessede@explicyte.com)
URL:https://www.bricbordeaux.com/en/event/techno-seminar-explicyte-bric-invitation/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/explicyte-presentation-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260625T093000
DTEND;TZID=Europe/Paris:20260625T120000
DTSTAMP:20260610T103113Z
CREATED:20260610T102528Z
LAST-MODIFIED:20260610T103113Z
UID:51893-1782379800-1782388800@www.bricbordeaux.com
SUMMARY:Thematic Seminar SBM departement: Extracellular Vesicles and Telocytes
DESCRIPTION:Sheela Abraham (Queen’s University\, Canada) and Luciano Borges (Federal University of São Paulo) have been invited by Amélie Guitart (BRIC Team 10) and François Moisan (BRIC Team 5) with the Department of Biological and Medical Sciences and the SBM’s Young Researchers Group \n\nDr Sheela A. Abraham (Sinclair Cancer Research Institute\, Queen’s University\, Kingston Canada) – “The language of cells\, how haematopoietic stem cells use extracellular vesicles to ‘sentir l’ambiance’ of the bone microenvironment”\nProf. Dr. Luciano de Figueiredo Borges (Université Fédérale de São Paulo) – “Les télocytes : une étoile montante de la recherche biomédicale”\n\nJune 25\, 2026\, at 9:30 a.m.\nBBS conference room\, University of Bordeaux\, 2 rue Dr Hoffmann Martinot \n  \n🎤 Ph.D. students and postdoctoral researchers: may participate by giving flash presentations (5 min) \n👉 Register by June 10 for flash presentations \n  \nAll information\n 
URL:https://www.bricbordeaux.com/en/event/thematic-seminar-sbm-departement-extracellular-vesicles-and-telocytes/
LOCATION:amphithéatre du BBS\, 2 rue Dr Hoffmann Martinot\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/seminaire-thematique-vesicule-24-06-2026.png
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260625T090000
DTEND;TZID=Europe/Paris:20260625T170000
DTSTAMP:20260624T125513Z
CREATED:20260617T080154Z
LAST-MODIFIED:20260624T125513Z
UID:51941-1782378000-1782406800@www.bricbordeaux.com
SUMMARY:Thesis Defense by Mathieu Bourgeais\, Team 2 BRIC & CBMN
DESCRIPTION:Organic Chemistry Thesis Defense: Mathieu Bourgeais\, team 2.1 \nThesis Title: \nSynthesis and Evaluation of Peptide Compounds for the Targeted Degradation of Oncoproteins (french presentation) \nThesis advisors: \nAbdel-Majid Khatib (BRIC team 2.1) et Gilles Guichard (IECB\, CBMN\, UMR 5248) \nDate and time of the defense: \nJune 25\, 2026\, 9 a.m. \n  \nLocation: \nConference room IECB\, 2 Rue Robert Escarpit\, 33600 Pessac \nVideo conference link: \nhttps://sanofi.zoom.us/j/99771203256?pwd=mNK7Iih0btybyAtw0oALnn3dA91D49.1&from=addon \nAbstract: \nThis thesis focuses on the design\, synthesis\, and evaluation of innovative peptide and peptidomimetic compounds intended for the modulation and targeted degradation of oncoproteins. Due to their selectivity and modularity\, peptides serve as ideal platforms for targeting hard-to-reach protein-protein interfaces and for exploiting endogenous cellular degradation mechanisms. In this context\, two main targets were explored: hDM2\, for its E3 ligase activity and its interaction with the tumor suppressor p53\, and furin\, a proprotein convertase involved in tumor progression.   \nIn the first phase\, constrained ligands mimicking the natural p53 helix were developed as peptide-foldamer hybrids incorporating oligourea segments and macrocyclization patterns derived from structures co-crystallized with hDM2. The exploitation of new cyclization opportunities that stabilize the original alpha-helix—notably through the introduction of cysteines and a mercaptoprolin residue—enabled the stiffening of compounds exhibiting high affinity for hDM2/hDMX. Careful sequence tuning also revealed that polycationic segments induced p53-independent cytotoxicity\, whereas macrocyclic peptide-foldamer hybrids with a net neutral charge restored p53’s antitumor activity in p53wt cancer cells. These optimized ligands thus constitute high-affinity\, stable\, and permeable modules suitable for subsequent integration into architectures that utilize hDM2 as a target or E3 ligase in the development of PROTAC-type peptidomimetic degraders.    \nIn a second phase\, a robust synthetic route for furin peptide inhibitors was established\, enabling the development of analogs active against the recombinant enzyme and in cellular environments. These ligands were then used as a basis for exploring targeted degradation strategies\, including hydrophobic tagging\, PROTACs targeting the Cereblon or von Hippel-Lindau E3 ligases\, and LYTACs targeting internalizing receptors. The results highlight the potential of these approaches while underscoring the constraints imposed by furin’s membrane localization and luminal orientation\, which limit the efficacy of certain degradation modalities.   \nTaken together\, these studies demonstrate that peptidomimetic engineering\, combined with macrocyclization strategies\, represents a promising approach for generating new bifunctional tools capable of selectively degrading oncoproteins. These advances open up new possibilities for the development of next-generation degraders targeting both intracellular and extracellular targets\, demonstrating that such architectures can be rationally optimized to ensure high affinity\, increased stability\, and the ability to direct proteins to proteasomal or lysosomal degradation pathways.  \n  \nNotice of Thesis Defense
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-mathieu-bourgeais-team-2-bric-cbmn/
LOCATION:Amphithéatre de l’IECB\, 2 rue Robert Escarpit\, Pessac\, 33600\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-mathieu-bourgeais-bric-team-2-25-06-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260623T140000
DTEND;TZID=Europe/Paris:20260623T170000
DTSTAMP:20260616T133839Z
CREATED:20260608T094824Z
LAST-MODIFIED:20260616T133839Z
UID:51863-1782223200-1782234000@www.bricbordeaux.com
SUMMARY:Thesis Defense Nasir ABBASI - 23-06-2026
DESCRIPTION:Ph.D. thesis in Cancer Biology by Nasir ABBASI\, Team 5.1 \nJoint supervision of the thesis by Audrey GROS (BRIC) and Slim KARKAR (IBGC) \nA Study of Tumor Heterogeneity in Sézary Syndrome Using Bioinformatics Approaches. (Presentation in French) \nTuesday\, June 23\, 2:00 p.m. \nCARF Conference Room (ex CGFB)\n146 Rue Léo Saignat\, 33000 Bordeaux \n  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-nasir-abbasi-23-06-2026/
LOCATION:CARF (ex CGFB)\, 146 rue Léo Saignat\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-nasir-abbasi-bric-team-5.1-23-06-2026-3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260622T150000
DTEND;TZID=Europe/Paris:20260622T160000
DTSTAMP:20260612T144504Z
CREATED:20260612T144504Z
LAST-MODIFIED:20260612T144504Z
UID:51909-1782140400-1782144000@www.bricbordeaux.com
SUMMARY:Invited seminar - Cédric Chaveroux - 22-06-2026
DESCRIPTION:Frederic Delom and his 2.2 team have invited Cédric Chaveroux to present his research. \nCédric Chaveroux\, Laboratoire de Biologie tissulaire et Ingénierie Thérapeutique – UMR 5305\, Lyon \nTitre :\nA non-canonical RNA damage signaling drives cell plasticity under translational stress: implications for colorectal tumor cell state transitions. (english presentation). \nBiosketch \nDr Cédric Chaveroux is a CNRS researcher and head of the Microenvironmental Stress Signaling and Epithelial Cell Fate team. His work focuses on the mechanisms by which epithelial tumor cells adapt to stress\, with a particular emphasis on RNA damage responses and cellular plasticity. His research investigates signaling pathways activated in response to alterations in RNA integrity\, particularly under conditions of translational stress and disrupted cellular homeostasis. He is especially interested in GCN2 kinase–mediated signaling as a key sensor and integrator of stress\, capable of reprogramming gene expression and cell fate decisions. In this context\, he explores how translation perturbations induced by microenvironmental and/or therapeutic stress contribute to the remodeling of cellular states and promote tumor progression.     \nAbstract \nBeyond its role in protein synthesis\, mRNA translation constitutes a central hub for stress response integration. Under microenvironmental or therapy-induced stress conditions\, its disruption triggers a coordinated set of molecular pathways collectively referred to as the RNA damage response. The dynamic interplay between these pathways plays a critical role in determining tumor cell fate. Our recent work identifies novel signaling mechanisms that enable tumor cells to tolerate translational stress\, thereby promoting their survival and plasticity in colorectal cancer. Beyond redefining the key molecular events underlying tumor cell plasticity\, pharmacological targeting of these mechanisms represents a promising therapeutic opportunity.
URL:https://www.bricbordeaux.com/en/event/invited-seminar-cedric-chaveroux-22-06-2026/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/bric-invited-seminar-cedric-chaveroux-22-06-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260616T093000
DTEND;TZID=Europe/Paris:20260616T103000
DTSTAMP:20260605T154908Z
CREATED:20260520T080733Z
LAST-MODIFIED:20260605T154908Z
UID:51689-1781602200-1781605800@www.bricbordeaux.com
SUMMARY:BRIC prestige seminar – Lionel LARUE
DESCRIPTION:As part of the prestigious seminars organized by our BRIC unit\, we are pleased to welcome Dr. Lionel Larue\, Inserm Research Director Emeritus\, and Dr. Véronique Delmas (CNRS Research Director) from the Chemistry and Modeling for Cancer Biology team (UMR9187 / U1196) at the Institut Curie. \nWe will take advantage of their visit to organize meetings with the researchers and students in our unit (see internal email) \nTheir research focused on the role of E-cadherin and β-catenin\, as well as other cadherins (such as N- and R-cadherin)\, in embryonic development\, using sophisticated genetically modified mouse models (knockout/knock-in\, etc.)\, contributing to the study of the role of these proteins and their alterations in pathophysiology. \nThey have long been interested in the development of various tissues and cell types\, including the mammary gland and melanocytes\, and their team has made a name for itself particularly in the study of melanoma. \n  \nThe seminar will be presented by Lionel Larue at 9:30 a.m. on Tuesday\, June 16\, 2026\, in a hybrid format \nBBS conference room\, 2 rue Dr Hoffmann Martinot. location map \nZoom ID 871 6813 2700  \nThe presentation will be in English. \n“The CDH1-ESR1-GRPR axis defines a sex-specific metastatic pathways in cancer ” \nAbstract: \nSex differences in cancer remain underexplored\, limiting precision medicine. We show that premenopausal women are more susceptible to certain cancers and identify ECAD as a key mediator of estrogen response. In melanoma\, an ECAD–βCAT–ERα–GRPR pathway drives female-specific tumor aggressiveness\, while targeting GRPR or ERα reduces metastasis. These findings highlight hormone-dependent mechanisms in non-classical cancers and support sex-specific therapeutic strategies\, including GPCR targeting.    \n If scientists from outside the BRIC unit would like to meet with Dr. Lionel Larue and Dr. Véronique Delmas\, please contact David Cappellen at david.cappellen@u-bordeaux.fr. \n  \nLionel Larue CV\nJoin the webinar on Zoom\n  \nCurie Institute report on the article published in Nature in June 2025: Targeting GRPR for sex hormone-dependent cancer after loss of E-cadherin
URL:https://www.bricbordeaux.com/en/event/bric-prestige-seminar-lionel-larue/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/05/seminaire-prestige-lionel-larue.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260605T140000
DTEND;TZID=Europe/Paris:20260605T170000
DTSTAMP:20260527T085102Z
CREATED:20260520T093617Z
LAST-MODIFIED:20260527T085102Z
UID:51696-1780668000-1780678800@www.bricbordeaux.com
SUMMARY:Thesis Defense Cloé Tessier
DESCRIPTION:Ph.D. thesis in Cancer Biology \nCloé Tessier\, team 1 BRAINSTRIM Brain tumor stroma\, resistance\, invasion and metabolism \nThesis supervision Lucie Brisson \nCaractérisation et rôle du catabolisme des gouttelettes lipidiques dans le glioblastome. \nFriday\, June 5\, 2:00 p.m. \nConference room IECB\, 2 Rue Robert Escarpit\, 33600 Pessac \n  \nNotice of thesis defense with abstract \n  \nWatch the video of Cloé Tessier (in French)\, recorded in July 2023\, in which she presents her team’s research topic in 180 seconds: finding new treatments for glioblastoma. \n  \n[vc_video link=’https://www.youtube.com/watch?v=4nAVOcMItck’]
URL:https://www.bricbordeaux.com/en/event/thesis-defense-cloe-tessier/
LOCATION:Amphithéatre de l’IECB\, 2 rue Robert Escarpit\, Pessac\, 33600\, France
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/05/soutenance-de-these-cloe-teissier-team-1-bric.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260529T140000
DTEND;TZID=Europe/Paris:20260529T170000
DTSTAMP:20260507T083601Z
CREATED:20260429T090905Z
LAST-MODIFIED:20260507T083601Z
UID:51578-1780063200-1780074000@www.bricbordeaux.com
SUMMARY:Seminar by Bruno Constantin\, invited by Team 4
DESCRIPTION:Dr. Bruno Constantin (CNRS Researcher\, 4CS Laboratory\, University of Poitiers) will give a lecture titled « Ion channels and cancer toward the concept of oncochannels ? » Friday\, May 29\, at 2:00 p.m.\, in the BBS lecture hall. \nEnglish presentation.  \nAbstract \nGrowing evidence indicates that ion channels\, particularly calcium channels\, play central roles in cancer biology. They contribute to key hallmarks of cancer\, including proliferation\, survival\, invasion\, metastasis\, and therapeutic resistance. Cancer stem cells\, in particular\, rely on ion channel–dependent signaling to sustain self-renewal and adaptability. These effects often arise from aberrant channel expression or activity\, enabling cancer cells to hijack physiological signaling pathways. This has led to the emergence of the concept of “oncochannels\,” referring to ion channels that actively drive tumor initiation and progression. Beyond improving our understanding of cancer pathophysiology\, this concept identifies ion channels as promising biomarkers and therapeutic targets. \nBiosketch \nWith a Master’s degree in Physiology and Cellular Biology (electrophysiology\, University of Poitiers)\, my research focuses on calcium signaling in physiology and disease. My early work addressed calcium dynamics during myogenesis and actin cytoskeleton remodeling (Ghent University).  \nAt CNRS\, I demonstrated the role of dystrophin in calcium homeostasis and ion channel regulation in skeletal muscle\, leading to studies on TRPC/α-syntrophin complex and their involvement in Duchenne muscular dystrophy\, as well as the therapeutic potential of mini-dystrophin. \nSince 2014\, I directed STIM and 4CS lab. My research has expanded to cancer and stem cell biology and has focused on calcium channels in neural and cancer stem cells\, particularly store-operated calcium entry (SOCE)\, and their roles in glioma cell self-renewal and invasion. I have also contributed to projects on TRP channels in invasive cancer cell migration across various cancer models.
URL:https://www.bricbordeaux.com/en/event/seminar-by-bruno-constantin-invited-by-team-4/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/04/invited-seminar-bruno-constantin-29-05-2026-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260506T133000
DTEND;TZID=Europe/Paris:20260506T170000
DTSTAMP:20260429T072629Z
CREATED:20260428T135446Z
LAST-MODIFIED:20260429T072629Z
UID:51558-1778074200-1778086800@www.bricbordeaux.com
SUMMARY:Defense of thesis Mariana SARAIVA\, team 4
DESCRIPTION:Defense of Mariana SARAIVA‘s thesis in Cancer Biology\, team 4 Digestive cancers associated with Helicobacter infection\, cancer stem cells and therapeutic strategies \nThesis supervision Armelle Ménard \nImplication des génotoxines bactériennes dans le remodelage du cytosquelette cellulaire et la carcinogenèse. \nWednesday\, May 6\, 1:30 p.m.\nBBS Conference Room\, 2 Rue du Dr. Hoffmann Martinot\, Bordeaux \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-mariana-da-silva-saraiva-team-4/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/04/soutenance-de-these-mariana-saraiva-team-4.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260413T160000
DTEND;TZID=Europe/Paris:20260413T190000
DTSTAMP:20260408T094156Z
CREATED:20260407T152059Z
LAST-MODIFIED:20260408T094156Z
UID:51426-1776096000-1776106800@www.bricbordeaux.com
SUMMARY:Thesis Defense Yiyang LIU\, team 2 RyTme
DESCRIPTION:Thesis Defense in Cancer Biology \nYiyang LIU\, team 2 RyTme\, co-supervision of thesis Majid Khatib and John W.M. Creemers (Laboratory of Biochemical Neuroendocrinology\, Center for Human Genetics\, KU Leuven\, Belgium) \n“The role of Furin in KRAS- and BRAF-mutant colorectal cancer” \nMonday\, April 13\, 4:00 p.m.\nAuditorium BMW 1\, ON2\, Campus Gasthuisberg\, KU Leuven\nLivestream: https://livestream.kuleuven.be (PIN: 063194)
URL:https://www.bricbordeaux.com/en/event/thesis-defense-yiyang-liu-team-2-rytme/
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/04/soutenance-de-these-yiyang-liu-team-2-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260319T100000
DTEND;TZID=Europe/Paris:20260319T170000
DTSTAMP:20260310T141853Z
CREATED:20251216T163329Z
LAST-MODIFIED:20260310T141853Z
UID:50745-1773914400-1773939600@www.bricbordeaux.com
SUMMARY:Seminar: “3D Models in Oncology” - From Design to Analysis
DESCRIPTION:Seminar  \n“3D Models in Oncology”\nFrom Design to Analysis \n  \nThe BRIC 3D Models Working Group – The Bordeaux Institute for Cancer Research (BRIC) is organizing a day dedicated to 3D models in oncology. Oral presentations will be in French and supporting materials in English.\n\n \nThursday\, March 19\, 2026 \n10am-17pm\nBordeaux\nconference room BBS – Bordeaux\, Biologie\, Santé\nor video : webinar zoom link\n(Webinar ID 885 7708 5527\, code 1903) \n  \nSign up here! \n  \n\nInvited scientists \nAudrey Ferrand\, CR INSERM – INSERM U1297\, Toulouse\nVéronique Maguer-Satta\, DR CNRS – INSERM U1052\, Lyon\nIsabelle Dupin\, PR Université de Bordeaux – INSERM U1045\, Bordeaux\nFlorent Ginhoux\, PR Université Paris Saclay – INSERM U1015\, Paris\nFlorian Levet\, IR Inserm – IINS / BIC\, Bordeaux\n \n  \nBRIC presentations and platforms  \n\n  \nDetailed program \n  \n#CellModel #Oncology #3DModel #Networking #TechnologyPlatforms #ScientificMeetings \n\nIn partnership with:\n\n\nFree event – registration required before March 6 \n  \nSign up here! \n  \nSponsoring and information :\nSandrine Poglio : sandrine.poglio@u-bordeaux.fr\nLaurence Bresson-Bepoldin : laurence.bresson-bepoldin@inserm.fr \n\nThanks to our sponsors
URL:https://www.bricbordeaux.com/en/event/seminar-3d-models-in-oncology-from-design-to-analysis/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/affiche-seminaire-3d-19-03-2026-avec-inscription.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260310T140000
DTEND;TZID=Europe/Paris:20260310T170000
DTSTAMP:20260302T132858Z
CREATED:20260210T161119Z
LAST-MODIFIED:20260302T132858Z
UID:51067-1773151200-1773162000@www.bricbordeaux.com
SUMMARY:Thesis defense Marianne Guilbard
DESCRIPTION:Thesis defense in Cancer Biology. \nMarianne Guilbard\, team 2 Oncogyne\, Frederic Delom \n“Tumor-adaptive functions of the secreted protein disulfide isomerase AGR2.” (thesis defense in french) \nTuesday\, March 10 at 2 p.m. \nBibliothèque\nInstitut Bergonié\, 229 cours de l’Argonne\, 33000 Bordeaux\, France \n\nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-marianne-guilbard/
LOCATION:Institut Bergonié\, 229 Cours de l'Argonne\, Bordeaux\, 33076\, France
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/02/soutenance-de-these-marianne-guilbard.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260224T143000
DTEND;TZID=Europe/Paris:20260224T153000
DTSTAMP:20260226T151449Z
CREATED:20260202T151141Z
LAST-MODIFIED:20260226T151449Z
UID:50956-1771943400-1771947000@www.bricbordeaux.com
SUMMARY:Andreas Bikfalvi seminar - The complexity of causality in cancer: A scientific and philosophical investigation
DESCRIPTION:Andreas Bikfalvi\, Professor Emeritus at the University of Bordeaux\, affiliated with BRIC Team 1\, recently defended a thesis in philosophy at the Sorbonne He offers us a summary of this in this seminar. \n“The complexity of causality in cancer: A scientific and philosophical investigation” \n📅 Tuesday\, February 24\, 2:30 p.m. \n🚩 BBS (Bordeaux Biology Health) conference room – 2 rue du Dr Hoffmann Martinot Bordeaux (Carreire site\, University of Bordeaux) \nor by video conference \nAbstract \nMy work explores the complex nature of causality in cancer biology\, particularly within the tumor microenvironment (TME)\, integrating philosophical perspectives\, mathematical modeling\, and experimental data. It traces the evolution of cancer theories from cell-based to microenvironment-focused models\, highlighting increased complexity in causal interpretation due to tumor heterogeneity. The “Hallmarks of Cancer” framework is discussed as a descriptive tool that lacks causal clarity\, prompting the use of multi-scale and formal causal models. \nTwo main theoretical approaches—Somatic Mutation Theory and Tissue Organization Field Theory—are compared and integrated\, with probabilistic models illustrating the variable influence of genetics\, cellular environment\, and microenvironmental factors. Case studies on diffuse gliomas and clear cell renal carcinoma demonstrate how advanced causal modeling (using DAGs\, SEM\, and Bayesian approaches) can clarify the interplay among invasion\, immunity\, metabolism\, and genetic mutations. The research also identifies key molecular pathways and therapeutic targets. \nMethodologically\, the work highlights the challenges of validating complex causal networks and advocates for systematically integrating causal analysis in biomedical research. A holistic\, interdisciplinary approach is essential for advancing both fundamental understanding and clinical applications in oncology. Additionally\, it is shown how biomedical research can enhance philosophical conceptual analysis and philosophical concepts biomedical research \nBiosketch \nBorn in Hungary and raised in Germany\, I hold both French and German citizenships. I graduated in medicine in France and completed my residency in hematology and oncology at the University of Kiel (Germany). I then pursued a PhD in science at INSERM in Paris\, where my research focused on the biology of growth factors\, particularly FGFs\, and their role in regulating the phenotype of endothelial cells.  \nIn 1991\, I joined Professor Daniel B. Rifkin’s laboratory in New York\, where I studied the mechanisms of action of different molecular forms of FGFs. Upon returning to France in 1995\, I joined the CNRS and then the University of Bordeaux as a professor of cell and molecular biology\, where I established and led a laboratory dedicated to tumor and vascular biology\, affiliated with INSERM as of 2000. My unit became part of the BRIC INSERM center in Bordeaux in 2022 (Team 1 of BRIC) Since 2025\, I am an emeritus professor. Alongside my scientific activities\, I am also involved in philosophy of science and earned a doctorate in this field from Paris 1 Panthéon-Sorbonne. \n  \nSee the replay : \n[vc_video link=’https://youtu.be/2BnstxoRyEo’]
URL:https://www.bricbordeaux.com/en/event/andreas-bikfalvi-seminar-the-complexity-of-causality-in-cancer-a-scientific-and-philosophical-investigation/
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/02/seminar-andreas-bikfalvi-24-02-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20260131
DTEND;VALUE=DATE:20260201
DTSTAMP:20260120T165008Z
CREATED:20250625T130142Z
LAST-MODIFIED:20260120T165008Z
UID:50850-1769817600-1769903999@www.bricbordeaux.com
SUMMARY:Digestive Cancer Open Day 2026
DESCRIPTION:2026 Open Day on Digestive Cancers on Saturday\, January 31\, 2026. \nBRIC is once again holding an Open Day at its premises in Bordeaux\, on the Carreire campus (BBS building). Find information on our website dedicated to the general public:  \n  \npatient website \n  \nThis initiative\, which is fully in line with the goal of scientific outreach\, aims to introduce the general public\, in a variety of formats\, to the daily lives of researchers and recent advances in the field of digestive cancer research. The programme includes : \n\n\nContinuous reception (except from 12:30 p.m. to 1:45 p.m.)\n\n\n\nSeminars on the Cancer Research/Care and Innovation Ecosystem in the Region (11 a.m. and 2 p.m.)\n\n\n\nInteractive guided tours of the laboratory\, including 3 workshops:\n\nWorkshop: “Discovering Living Cells”\n\n\n\nWorkshop: “The journey of a sample”: from biopsy to treatment\n\n\n\nEscape Game Workshop\n\n\n\n\n\nWorkshops on “Observation of tumor tissues” (ongoing)\n\n\n\nExchange activity: “Ask all your questions” (ongoing)\n\n\n\nGuided discoveries into the mechanisms of cancer\, drug development\, and various therapies. (ongoing)\n\n\n\nStand of the Gironde Cancer League (continuous)\n\n\n\nDiscovery of a biological model (ongoing)\n\n\nTours departing with workshop participation at 10 a.m.\, 11 a.m.\, 2 p.m.\, and 3 p.m. Other activities ongoing throughout the day. \n\nCome and discuss\, around posters or mini-seminars\, with various contributors involved in the research: – Academic research professionals (researchers and teacher-researchers\, engineers and technicians\, doctoral students and interns) – Clinical research professionals – Clinicians\, including surgeons and oncologists \n\nPatient associations\, including La Ligue Contre le Cancer de Gironde (the Gironde Cancer League) and a start-up company spun off from the laboratory\, will also be present! \n\nCome visit the laboratory and take the opportunity to put on a lab coat and gloves and participate in fun workshops! This project is led by teams 3\, 4\, and 8 at BRIC\, in collaboration with several supervisory bodies (Inserm\, University of Bordeaux) and scientific partners: (Bordeaux University Hospital\, OncoProt\, BeLiver\, Bergonié Institute). \n  \nAccess: \n🚘Apart from the parking spaces reserved for university staff (badge required)\, you will find spaces closer by on the sidewalk along the wall on Rue du Dr Hoffmann Martinot. Otherwise\, there is a parking lot reserved for visitors a 5-minute walk away\, located at 125 Bethmann Street. \n🚊Take tram A to the Saint Augustin stop\, then follow the “cycles et piétons” (cycles and pedestrians) markings on the ground across the CHU campus. \n🚍Several bus lines nearby\, see location map \n  \nlocation map
URL:https://www.bricbordeaux.com/en/event/digestive-cancer-open-day-2026/
LOCATION:Accueil bâtiment Bordeaux Biologie Santé (BBS)\, 2 rue Dr Hoffmann Martinot\, Bordeaux\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/06/vignette-jpo-cancers-digestifs-bric-31-01-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260127T140000
DTEND;TZID=Europe/Paris:20260127T150000
DTSTAMP:20260106T111830Z
CREATED:20260106T111830Z
LAST-MODIFIED:20260106T111830Z
UID:50730-1769522400-1769526000@www.bricbordeaux.com
SUMMARY:Invited Seminar Kevin Boyé
DESCRIPTION:We invite Kevin Boyé to give a seminar open to the scientific community. \nDr. Kevin Boyé\nCRCN INSERM Paris Cardiovascular Research Center – 56 Rue Leblanc\, 75015 Paris\nCo-founder of D2B3 – 101 College Street\, 06511 New Haven\, CT\, USA \n \n“Unlocking the Blood–Brain Barrier during Glioblastoma progression” \n📆 Tuesday\, January 27\, 2 p.m.\n🚩 BBS Conference Room\, 2 rue Dr Hoffmann Martinot\, Carreire site\, University of Bordeaux \nAbstract \nBlood vessels in the brain form 600 kilometers of specialized blood-brain barrier (BBB) that protect the brain from toxins and pathogens\, thereby ensuring homeostasis and proper neurological function. However\, BBB impermeability also severely limits brain drug delivery during many neurological disorders. \nGlioblastoma (GBM) is the most aggressive primary brain tumor with a median survival of 12–15 months. Although BBB integrity is partially disrupted within the tumor core\, the highly invasive nature of GBM cells into the BBB-competent brain parenchyma strongly limits the delivery and efficacy of therapeutic molecules\, leading to inevitable recurrence after surgical resection. Hence\, developing tailored therapeutic strategies that can transiently and safely modulate BBB permeability without compromising its protective function remains a major unmet clinical need. \nWe recently identified the endothelial receptor Unc5B and its ligand Netrin-1 as central regulators of BBB integrity. Single-cell RNA sequencing revealed that this pathway controls a core BBB gene expression program of over 100 genes involved in tight junction organization\, nutrient and ion transport\, and efflux pump function. To harness this mechanism therapeutically\, we developed\, optimized\, and patented a fully human monoclonal antibody (Anti-Unc5B) that specifically blocks Netrin-1 binding to Unc5B. \nFollowing intravenous injection\, Anti-Unc5B induces a brain-wide and brain-specific\, opening of the BBB for up to six hours\, prior to barrier resealing. This transient permeability window is size-selective\, cumulative and safe. Using this BBB-permeabilizing strategy\, we could enhance the delivery and efficacy of a wide variety of therapeutic molecules including chemotherapies\, tyrosine kinase inhibitors and nanobodies during GBM progression\, resulting in increased tumor cell apoptosis\, reduced tumor growth and improved survival. \nBiosketch \nI completed my PhD in the laboratory of Pr. Andreas Bikfalvi under the supervision of Dr. Clotilde Billottet (INSERM U1029\, France)\, where I identified the chemokine receptor CXCR3-A and its ligand CXCL4L1 as a novel signaling pathway essential for brain tumor progression (Boyé K. et al.\, Nature Communications 2017; Boyé K. et al.\, Scientific Reports 2017; Quemener C et al. Cancer Research 2016). However\, like most therapeutic molecules developed for neurological diseases\, intravenously injected CXCR3-A inhibitors were unlikely to efficiently cross the blood–brain barrier (BBB). \nTo overcome this limitation\, I joined the laboratory of Pr. Anne Eichmann at Yale University (New Haven\, USA) as a postdoctoral fellow (2017-2022)\, where I investigated mechanisms regulating vascular barrier integrity (Genet G.\, Boyé K. et al. Nature Communication 2019; Zhang F. et al. Science 2018)\, with a particular focus on the BBB (Boyé K. et al.\, Nature Communications 2022). I identified the endothelial Unc5B receptor and its ligand Netrin-1 as a key signaling pathway required to maintain BBB integrity. I subsequently developed a human monoclonal antibody that block Netrin-1 binding to Unc5B\, enabling a reversible and controlled BBB opening leading to brain delivery of bioactive molecules (Two Patents in 2023). \n  \nSince 2023\, I am a Group Leader (CRCN) at the Paris Cardiovascular Research Center (INSERM U970). My group is currently funded by an FRM “Amorçage jeunes équipes” (2023-2026)\, an ANR PRC (Coordinator; 2026 – 2028) and an INCa PLBIO (Coordinator; 2026 – 2028). My research program focuses on: \n\nOptimizing brain drug delivery beyond the BBB during brain tumor progression.\nEnhancing BBB integrity in diseases with BBB dysfunction.\n\nWe recently reported a BBB gene-expression program zonated along the arteriovenous axis that can be tuned to increased brain drug delivery (Furtado et al.\, PNAS 2024). \n  \nIn 2024 I co-founded D2B3 (https://d2b3.bio)\, a start-up company spun out of Yale University\, aiming to improve brain drug delivery in patients using our patented BBB-permeabilization technology.
URL:https://www.bricbordeaux.com/en/event/invited-seminar-kevin-boye/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/01/invited-seminar-kevin-boye-27-01-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251218T140000
DTEND;TZID=Europe/Paris:20251218T170000
DTSTAMP:20251216T160428Z
CREATED:20251216T160142Z
LAST-MODIFIED:20251216T160428Z
UID:50583-1766066400-1766077200@www.bricbordeaux.com
SUMMARY:Thesis defense Zahraa FAKIH - team 05
DESCRIPTION:Thesis defense in Cell Biology and Physiopathology of Zahraa FAKIH \n🎤 Études Moléculaires des Anomalies de Pigmentation dans Le Xeroderma Pigmentosum de Type C\nThesis supervisor : Muriel CARIO équipe 5 – Recherche translationnelle en cancérologie cutanée et maladies cutanées rares (TRIO2). \n📅 Thursday\, December 18\, 2025\, 2:00 p.m.\n🚩 salle de conférence BBS – 2 rue Docteur Hoffman Martinot\, Site Carreire\, 33000\, Bordeaux \n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-zahraa-fakih-team-05/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/soutenance-de-these-zahraa-fakih2.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251217T140000
DTEND;TZID=Europe/Paris:20251217T170000
DTSTAMP:20251211T163743Z
CREATED:20251211T163046Z
LAST-MODIFIED:20251211T163743Z
UID:50556-1765980000-1765990800@www.bricbordeaux.com
SUMMARY:Thesis defense Lucile Rouyer\, team 3
DESCRIPTION:Thesis defense in Cancer Biology by Lucile Rouyer\, team 03 – Liver Cancers and Tumor Invasion \n\n\n\n\nThesis supervisor : Frederic Saltel \n“Étude et modélisation in vitro des interfaces au cours de la progression tumorale.” \n\n\n\n\n📅 Wednesday\, December 17\, 2 p.m. \n\n\n🚩 Amphi BBS\, campus Carreire\, Université de Bordeaux \n\n\n\n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-lucile-rouyer-team-3/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/soutenance-de-these-lucile-rouyer.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251217T140000
DTEND;TZID=Europe/Paris:20251217T170000
DTSTAMP:20251211T161633Z
CREATED:20251211T160926Z
LAST-MODIFIED:20251211T161633Z
UID:50546-1765980000-1765990800@www.bricbordeaux.com
SUMMARY:Thesis defense by Ferial KHALIFE\, team 5.1
DESCRIPTION:Thesis defense in Cancer Biology by Ferial KHALIFE\, team 5.1 Skin carcinomas\, Photoprotection\, Metabolism \nThesis supervisor Hamid-Reza Rezvani. \nTitle : Ciblage thérapeutique de la vulnérabilité métabolique des carcinomes épidermoïdes cutanés. \n📅 Wednesday\, December 17\, 2 p.m. \n🚩 Module 1.1\, campus Carreire\, bâtiment CROUS\, 1er étage\nUniversité de Bordeaux\, 146 Rue Léo Saignat\, 33000 Bordeaux \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-ferial-khalife-team-5-1/
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/soutenance-de-these-ferial-khalife.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251212T140000
DTEND;TZID=Europe/Paris:20251212T170000
DTSTAMP:20251208T174943Z
CREATED:20251208T174136Z
LAST-MODIFIED:20251208T174943Z
UID:50523-1765548000-1765558800@www.bricbordeaux.com
SUMMARY:Thesis defense: Thibaut Matis - Team 8
DESCRIPTION:Thesis defense in Genetics of Thibaut Matis\, team 8 – Biotherapies Genetics and Oncology (BioGO) \n\n\n\n\n“CISCO : Etude des régions CIS régulatrices de l’expression du gène PTEN et leur implication dans la maladie de COwden.” \nThesis supervision : Nicolas Sevenet \n\n\n\n\n📆 Friday\, December 12\, 2 p.m \n\n\n🚩 Lecture Hall 12\, Carreire Campus\, 146 rue Leo Saignat Bordeaux (To find Lecture Hall 12 from the BBS\, follow the map) \n\n\n\nnotice of defense with summary \n 
URL:https://www.bricbordeaux.com/en/event/thesis-defense-thibaut-matis-team-8/
LOCATION:amphi 12\, site Carreire\, 146 rue Leo Saignat\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/soutenance-de-these-thibaut-matis.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251210T140000
DTEND;TZID=Europe/Paris:20251210T170000
DTSTAMP:20251204T164723Z
CREATED:20251204T163408Z
LAST-MODIFIED:20251204T164723Z
UID:50495-1765375200-1765386000@www.bricbordeaux.com
SUMMARY:Thesis defense Lea Pechtimaldjian\, team Trio2
DESCRIPTION:Soutenance de thèse de Léa Pechtimaldjian\, équipe Equipe: 5.2 Cutaneous lymphomas\, Vascular tumors\, Tissue engineering (M. Beylot-Barry\, L. Bresson-Bepoldin) \nTitre de thèse: “Etudes des télocytes cutanés dans l’hémangiome infantile: caractérisation\, propriétés angiogéniques et approches thérapeutiques” \nSpécialité: Biologie cellulaire et physiopathologie \nDirecteur de thèse: François Moisan \nMercredi 10 décembre 2025\, 14h\nAmphi BBS\, 2 rue Dr Hoffmann Martinot Bordeaux \n  \nnotice of defense with summary
URL:https://www.bricbordeaux.com/en/event/thesis-defense-lea-pechtimaldjian-team-trio2/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/soutenance-de-these-lea-pechtimaldjian.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251210T110000
DTEND;TZID=Europe/Paris:20251210T120000
DTSTAMP:20251204T154347Z
CREATED:20251204T154347Z
LAST-MODIFIED:20251204T154347Z
UID:50485-1765364400-1765368000@www.bricbordeaux.com
SUMMARY:Invited seminar Bernhard Wehrle-Haller
DESCRIPTION:On the occasion of Léa Pechtimaldjian‘s thesis\, Team 5 (TRIO2) invites Bernhard Wehrle-Haller\, member of the jury\, to present a seminar to the scientific community. \nBernhard Wehrle-Haller PhD\nUniversity Medical Center\, Geneva\, Switzerland \n“The multiple roles of integrins in the assembly of fibronectin fibrils in the tumor stroma” \nAbstract:\nThe formation and growth of tumors depends on oxygen supply\, but also on mechanical support through increased synthesis of the extracellular matrix. Increased extracellular matrix stiffness enhances the survival capacity of tumor cells under therapeutic stress. At the same time\, tumor cells stimulate host cells to produce a supportive extracellular matrix. The mechanisms of this feedback are not well understood\, and there is no treatment to reverse the fibrotic response in the tumor stroma. Since integrins are essential receptors for tumor binding to the extracellular matrix\, but are also involved in the synthesis of extracellular matrix fibers\, we asked about the nature of intracellular connections and intracellular signaling that control how integrins are used by tumor or stromal cells in tumors. In a clinical approach\, we analyzed different types of glioblastoma to better understand the physiological roles of integrins in this type of cancer. \nBiography:\nStudied biochemistry in Basel\, Switzerland; Thesis in the field of extracellular matrix (tenascin\, laminin\, fibronectin\, and neurite growth)\, Biozentrum Basel\, Switzerland; Postdoc: in Oregon\, US\, directional migration of embryonic melanoblasts and role of growth factors; Return to Switzerland\, Geneva\, then appointment as Associate Professor\, role of integrin family receptors in cell adhesion and migration.  \n  \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-bernhard-wehrle-haller/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/12/bernhard-wehrle-haller-2025-12-10.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251208T140000
DTEND;TZID=Europe/Paris:20251208T150000
DTSTAMP:20251107T144403Z
CREATED:20251107T142441Z
LAST-MODIFIED:20251107T144403Z
UID:50347-1765202400-1765206000@www.bricbordeaux.com
SUMMARY:Imaging presentation: CRYO-FIB-SEM - 08-12-2025
DESCRIPTION:What is the purpose of a CRYO-FIB-SEM in Biology and Biomaterials in Bordeaux? (Présentation en français)\nEtienne Gontier\, PhD.\nResponsable BIC – Electronique\nIngénieur de recherche HC\nBordeaux Imaging Center\n\n\nAbstract:\n\nA cryoFIBSEM is a high-resolution scanning electron microscope equipped with a focused ion beam (FIB) column and a cryo-observation stage. In addition to being a conventional SEM\, samples can be imaged in 3D to obtain high-resolution volumes (3nm voxel) after abrasion using the FIB beam\, with or without correlative microscopy. It is also possible to generate these volumes from vitrified samples and capture the 3D ultrastructure in a state close to its native state. In addition\, soft materials such as polymers\, biological samples\, and many other systems can deform\, melt\, or become amorphous under FIB milling and SEM imaging conditions at room temperature. Thanks to cryo-FIB/SEM\, the sample is cooled to cryogenic temperatures (-130°C) in order to minimize these artifacts. This allows FIB cross-sections and SEM images to be produced with +/- chemical analysis of beam-sensitive materials\, with minimal deformation. Finally\, this technology enables\, among other things\, the preparation of cryogenic FIB lamellae for cryo-MET analysis.\n\nThe aim of this presentation will be to introduce this comprehensive\, innovative new electron microscopy equipment\, which is new to Bordeaux and the surrounding region. Thus\, initially\, the context in which this purchase is being made and the technological aspects will be explained. Next\, and most importantly\, the various possible applications will be presented in the form of concrete examples. We will conclude with a discussion.
URL:https://www.bricbordeaux.com/en/event/imaging-presentation-cryo-fib-sem-08-12-2025/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/presentation-bic-cryo-fib-sem-08-12-2025.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251125T140000
DTEND;TZID=Europe/Paris:20251125T170000
DTSTAMP:20251124T163517Z
CREATED:20251124T160643Z
LAST-MODIFIED:20251124T163517Z
UID:50424-1764079200-1764090000@www.bricbordeaux.com
SUMMARY:Thesis defense by Yasmine Pobiédonoscew - Team 11
DESCRIPTION:Thesis defense in Cancer Biology. \nYasmine POBIEDONOSCEW\, team 11 \nWork supervised by Ms. Béatrice TURCQ \nIdentification des cellules souches leucémiques de la leucémie myéloïde chronique dans un nouveau modèle murin. \n  \n  \nNotice of defense with summary and jury \n  \n📆 Tuesday\, November 25\, 2 p.m. \n🚩Salle de conférence – Centre d’Appui à la Recherche et de Formation (CARF) 146 rue Léo Saignat 33000 Bordeaux
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-yasmine-pobiedonoscew-team-11/
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/soutenance-de-these-yasmine-pobiedonoscew.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251124T170000
DTEND;TZID=Europe/Paris:20251124T200000
DTSTAMP:20251124T155117Z
CREATED:20251124T155117Z
LAST-MODIFIED:20251124T155117Z
UID:50422-1764003600-1764014400@www.bricbordeaux.com
SUMMARY:HDR defense Audrey Michot team 9
DESCRIPTION:Audrey Michot\, MD\, PHD will defend her HDR (Habilitation à Diriger la Recherche\, or accreditation to supervise research)\, specializing in Life and Health Sciences. \nTitle : Optimisation de la prise en charge des sarcomes des tissus mous : de la prédiction des rechutes à l’innovation chirurgicale. \nMonday\, November 24\, 5 p.m. \nInstitut Bergonié 229 cours de l’Argonne 33000 Bordeaux
URL:https://www.bricbordeaux.com/en/event/hdr-defense-audrey-michot-team-9/
LOCATION:Institut Bergonié\, 229 Cours de l'Argonne\, Bordeaux\, 33076\, France
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/soutenance-hdr-audrey-michot-24-11-2025.jpg
END:VEVENT
END:VCALENDAR