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X-WR-CALDESC:Events for Bordeaux Institute of Oncology
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DTSTART;TZID=Europe/Paris:20260713T150000
DTEND;TZID=Europe/Paris:20260713T190000
DTSTAMP:20260703T095129Z
CREATED:20260626T130345Z
LAST-MODIFIED:20260703T095129Z
UID:52018-1783954800-1783969200@www.bricbordeaux.com
SUMMARY:thesis defense Chloé Porcheron\, team 2.1
DESCRIPTION:Chloé Porcheron\, team 2.1 \nPhD specialty: Cancer biology. \nRôles de PCSK7 et PCSK9 dans la progression tumorale et la réponse immunitaire associée. \nJoint supervision Majid Khatib and Nabil Seidah (Director of the Laboratory of Biochemical Neuroendocrinology Montreal Clinical Research Institute – IRCM) \nJuly 13\, 2026\, at 3:00 p.m.\nLieu : Amphithéatre du BBS (bâtiment biologie santé) site Carreire Université de Bordeaux 2 rue Docteur Hoffmann Martinot\, Bordeaux et visio\n\n\nLien de visio - code secret 925758\n\n\n\n\nJury members: \n\nPERREAULT Claude\, Professeur\, Université de Montréal\, Président du Jury \nKHATIB A-Majid\, Directeur de recherche\, Université de Bordeaux\, Directeur de thèse \nSEIDAH Nabil G.\, Directeur de recherche\, Université de Montréal\, Directeur de thèse \nLALLOUÉ Fabrice\, Professeur\, Université de Limoges\, Rapporteur \nSEGUI Bruno\, Professeur\, Université de Toulouse\, Rapporteur \nTEICHMANN Martin\, Professeur\, Université de Bordeaux\, Examinateur \nMme. DUBOIS Claire\, Professeure\, Université de Sherbrooke\, Examinateur  \nMme. FONTES Ghislaine\, Associée de recherche\, Université de Mc Gill\, Examinatrice  \n\n \nSoutenance : \n\nJuly 13\, 2026\, at 3:00 p.m.\nLocation: BBS conference room\, Carreire Campus\, University of Bordeaux\n2 rue Docteur Hoffmann Martinot\, Bordeaux\n\nAbstract: \n\nLes proprotéines convertases (PCs) sont une famille de 9 sérines protéases sécrétoires reconnues pour le clivage de nombreux substrats pour leur maturation. Les PCs sont impliquées dans de nombreux processus physiologiques dus à la variabilité des substrats\, c’est pourquoi la dérégulation de leur expression ou de leur activité peut mener à diverses pathologies dont le cancer.\nBien que PCSK7 soit la convertase la plus ancienne de la famille des PCs\, son rôle physiologique reste très peu caractérisé. Ce n’est que récemment que PCSK7 a été associée au métabolisme des lipides par la régulation des niveaux de l’apoB et de l’apoA-V sans aucune activité protéolytique. Ce qui classe PCSK7\, comme le dernier membre PCSK9\, comme une PC possédant une fonction non enzymatique. PCSK7 est exprimée de façon ubiquitaire dans l’organisme\, cependant elle est retrouvée enrichie dans les organes lymphoïdes au niveau tissulaire et dans les cellules immunitaires\, plus particulièrement dans les lymphocytes T\, au niveau cellulaire. Malgré ces observations\, le rôle de PCSK7 dans la réponse immunitaire reste largement inconnu.\nAfin de définir un possible rôle de PCSK7 dans l’immunité\, nous nous sommes d’abord intéressés aux banques de données humaines pour étudier l’expression de PCSK7 parmi tous les facteurs responsables de la réponse immunitaire. Ces données ont mis en évidence une corrélation positive entre les niveaux d’expression des ARN codant pour PCSK7 et certains points de contrôle immunitaires\, qui sont des protéines de surface inhibitrices de la fonction des lymphocytes T. Nous avons ainsi étudié les niveaux d’expression des points de contrôle immunitaires au niveau intracellulaires et à la surface cellulaire en modulant l’expression de PCSK7 dans différents modèles in vitro tels qu’une lignée cellulaire d’hépatocytes humains\, des lymphocytes T murins isolés de la rate et des lymphocytes T humains provenant d’échantillons de sang de donneurs. Ainsi\, ces études ont démontré le rôle important de PCSK7 dans la régulation des niveaux des points de contrôle immunitaires.\nLes immunothérapies basées sur l’inhibition des points de contrôles immunitaires ont représenté une réelle avancée dans le traitement du cancer mais celles-ci restent peu efficaces pour une majorité de patients. C’est pourquoi nous avons étudié le possible rôle thérapeutique de l’inhibition de PCSK7 dans la progression tumorale\, seule ou en combinaison avec l’inhibition de PCSK9\, déjà reconnue comme un médiateur important de la réponse immunitaire antitumorale. Ainsi\, la délétion simple de Pcsk7 ou de Pcsk9 chez les souris permet une réduction du nombre de métastases hépatiques du cancer colorectal d’environ 50%\, tandis que la double délétion Pcsk7/Pcsk9 permet une réduction du développement métastatique d’environ 90%. En effet\, l’absence de Pcsk7 et de Pcsk9 favorise l’infiltration des lymphocytes T CD8+ dans les tumeurs hépatiques et réduit l’expression des points de contrôles immunitaires améliorant ainsi l’activité cytotoxique des lymphocytes T infiltrés.\nPour conclure\, cette étude décrit un nouveau rôle de PCSK7 dans l’immunité\, par la régulation des niveaux d’expression des points de contrôles immunitaires\, rationalisant ainsi l’utilisation d’inhibiteurs de PCSK7 dans les immunothérapies seules ou en combinaison avec un inhibiteur de PCSK9 dans le traitement du cancer.\n\nMots clés : \n\nproprotéine convertase subtilisine/kéxine type 7 (PCSK7)\, proprotéine convertase subtilisine/kéxine type 9 (PCSK9)\, réponse immunitaire antitumorale\, points de contrôles immunitaires\, métastases hépatiques\, lymphocytes T CD8+\n\n 
URL:https://www.bricbordeaux.com/en/event/thesis-defense-chloe-porcheron-team-2-1/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/soutenance-de-these-chloe-porcheron-team-2.1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260910T140000
DTEND;TZID=Europe/Paris:20260910T170000
DTSTAMP:20260904T081031Z
CREATED:20260828T125729Z
LAST-MODIFIED:20260904T081031Z
UID:52441-1789048800-1789059600@www.bricbordeaux.com
SUMMARY:Thesis Defense Julia ROSSI
DESCRIPTION:Thesis Defense Julia ROSSI\, team 8 Biotherapies Genetics and Oncology (BioGO) \nThesis Supervision Sandrine Dabernat \nSpecialization: Cancer Biology \nTitle: Ingénierie ciblée de la niche tumorale par vecteurs lentiviraux pour améliorer l’efficacité des cellules CAR T dans le cancer du pancréas \nThursday\, September 10\, 2026\, 2:00 p.m. \n\n\n\nBBS Conference Room\, Carreire Campus\, University of Bordeaux\n2 rue Dr Hoffmann Martinot Bordeaux. \n\n\n\n\n\n\n\n\nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-julia-rossi/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/08/soutenance-de-these-julia-rossi-team-8.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260914T140000
DTEND;TZID=Europe/Paris:20260914T170000
DTSTAMP:20260909T094132Z
CREATED:20260828T095200Z
LAST-MODIFIED:20260909T094132Z
UID:52433-1789394400-1789405200@www.bricbordeaux.com
SUMMARY:Thesis Defense by Léana PERIGNON
DESCRIPTION:Thesis Defense by Léana PERIGNON\, team 8 Biotherapies Genetics and Oncology (BioGO) \nThesis Supervision David Cappellen \nSpecialization: Cancer Biology. \nTitle : Modélisation par CRISPR-Cas9 de pertes d’hétérozygotie au locus 11p15 et étude de leur rôle dans l’oncogenèse des tumeurs pédiatriques. \nMonday\, September 14\, 2:00 p.m. \nBBS Conference Room\, Carreire Campus\, University of Bordeaux\n2 rue Dr Hoffmann Martinot Bordeaux. \n  \nThesis Defense Announcement with Abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-leana-perignon/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/08/soutenance-de-these-leana-perignon-team-8.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260922T140000
DTEND;TZID=Europe/Paris:20260922T170000
DTSTAMP:20260915T093755Z
CREATED:20260831T100417Z
LAST-MODIFIED:20260915T093755Z
UID:52483-1790085600-1790096400@www.bricbordeaux.com
SUMMARY:Thesis Defense Arthur MARICHEZ
DESCRIPTION:Thesis Defense Arthur MARICHEZ\, team 03 – Liver Cancers and Tumor Invasion \nSpecialization: Cancer Biology \nThesis Supervision Pr Laurence CHICHE \nTitle : Caractérisation du cholangiocarcinome extra-hépatique et développement de modèles prédictifs diagnostiques fondés sur le profilage protéomique. \nTuesday\, September 22\, 2:00 p.m. \nSalle Vasco de Gamma\nCentre Médico-Chirurgical Magellan\nHôpital Haut Lévêque\n1 Avenue de Magellan\n33600 Pessac \nPlease note: The time and location listed in the defense announcement below are incorrect. The defense will take place at 2:00 p.m. in the Vasco de Gamma room.  \nNotice of thesis defense with abstract
URL:https://www.bricbordeaux.com/en/event/thesis-defense-arthur-marichez/
LOCATION:Salle Vasco de Gamma\, Hopital Haut Leveque\, 1 Avenue de Magellan\, Pessac\, 33600
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/08/soutenance-de-these-arthur-marichez-team-3.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20260929T090000
DTEND;TZID=Europe/Paris:20260929T100000
DTSTAMP:20260731T090748Z
CREATED:20260728T151219Z
LAST-MODIFIED:20260731T090748Z
UID:52296-1790672400-1790676000@www.bricbordeaux.com
SUMMARY:Invited seminar Vincent Hyenne - BRIC team 3
DESCRIPTION:Violaine Moreau and Clotilde Billottet\, from Team 3\, have invited Vincent Hyenne to give a seminar. \nVincent Hyenne is the head of the EXPLORE group at the Tumor Biomechanics lab\, INSERM UMR_S1109\, Centre de Recherche en Biomédecine de Strasbourg. \nThe EXPLORE group is studying the priming of metastatic niches by extracellular vesicles \nTitle : Tumor-derived extracellular vesicles facilitate metastasis onset. \nAbstract \nTumor extracellular vesicles (EVs) promote tumor growth and metastasis by mediating the communication between cancer cells and stromal cells. Yet\, how they are generated and how they spread in the organism to modify the microenvironment in distant organs remains unclear. In the past\, we found that Ral GTPases regulate EVs secretion by maintaining the homeostasis of their compartments of origin\, the multivesicular bodies (MVBs). To explore the molecular and cellular mechanisms through which RalA/B drive exosome secretion\, we characterized their proximal interactome and identified EHD4 as a new Ral partner involved in EV secretion. Using various photonic and electronic imaging approaches\, we propose that Ral-dependent recruitment of EHD4 to MVBs promotes their maturation and movement. In parallel\, we are investigating the function of tumor EVs in the formation of pre-metastatic niches. Combining zebrafish and mouse models\, we show that tumor EVs induce a fast mobilization and activation of neutrophils\, which facilitate metastasis initiation.       \nBiosketch \nVincent loves watching and imaging living (and anesthetized) animals. He did his PhD in Jussieu\, Paris on epithelial polarity in mouse early embryonic development (B. Maro lab). He then moved to IRIC (Labbé lab\, Montreal\, Québec) where he studied the establishment of cell polarity\, and its link with vesicular trafficking in C. elegans. Back in France at the IGBMC (Labouesse lab\, Illkirch)\, he got fascinated by exosomes and extracellular vesicles (EVs) and identified new genes required for their secretion in C. elegans. He joined the Tumor Biomechanics lab\, where he got recruited at CNRS in 2016 to study the secretion\, spreading and function of tumor EVs in metastasis in mice and zebrafish. He is in charge of the fish facility and has to admit that zebrafish\, also not being a nematode\, is pretty cool. Vincent is a board member of the French Society of Extracellular Vesicles (FSEV) and the REVE (Réseau Est des Vésicules Extracellulaires). Vincent loves nothing more than traveling with his family\, except maybe a good book\, or a basketball game\, or a glass of good wine. \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-vincent-hyenne-bric-team-3/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/07/invited-seminar-vincent-hyenne-29-09-2026-1.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261001
DTEND;VALUE=DATE:20261003
DTSTAMP:20260710T085248Z
CREATED:20260622T103635Z
LAST-MODIFIED:20260710T085248Z
UID:51956-1790812800-1790985599@www.bricbordeaux.com
SUMMARY:Young Scientist Cancer Congress (YS2C) 2026
DESCRIPTION:Joaquim Javary\, a postdoc in Team 4\, is a member of the organizing committee for this event. \nYoung Scientist Cancer Congress (YS2C)\nAn international scientific meeting dedicated to early-career researchers & clinicians in cancer research\, bringing together a strong French–German core with a broad international outreach. \nThe 4th Young Scientist Cancer Congress (YS2C) will take place at the Amphitheater of IUCT-Oncopole\, Toulouse\, France\, on October 1-2\, 2026. Organized by young scientists and clinicians\, YS2C aims to showcase the work of early-career researchers and foster exchange across the cancer research community. \nThis year’s theme\, “Advances in Cancer Therapeutics\,” will highlight innovative research at the interface of fundamental\, translational\, and clinical oncology. \nWe are pleased to welcome an outstanding panel of keynote speakers: \nFlorence Dalenc (IUCT-Oncopole\, France)\nChris Marine (VIB-KU Leuven Center for Human Genetics\, Belgium)\nAltuna Akalin (Max Delbrück Center\, Germany)\nDafna Gold Melchior (Science Communication Expert)\nMarta Kovatcheva (IFOM ETS – The AIRC Institute of Molecular Oncology\, Italy)\nLeona Knox (Patient Advocate\, Solving Kids’ Cancer UK)\nSebastiaan Van Heesch (Princess Máxima Center for Pediatric Oncology\, the Netherlands)\nDaniela Marin (Senior Editor\, The Lancet Hematology) \nIn addition to keynote lectures\, YS2C 2026 will feature several interactive and networking opportunities\, including a Hackathon\, a Physician Corner\, and Meet the Editor sessions. \n  \n📝 We warmly encourage you to register and submit your abstract: https://www.ys2c.org/registration.php. \n  \n📅 Deadlines \nTalks: June 30\, 2026 July 15\,2026\nPosters: July 30\, 2026 \nBest posters will be selected for a lightning presentation. \n  \nRegistration is free but mandatory and open to the entire scientific community. More information is available on our website: www.ys2c.org. \nFor any questions\, please contact the organizing committee at ys2conference@gmail.com. \n  \nWe thank all our partners and sponsors for their generous support and look forward to welcoming many of you to YS2C 2026 in Toulouse. \nBest regards\, \nThe YS2C Organizing Committee
URL:https://www.bricbordeaux.com/en/event/young-scientist-cancer-congress-ys2c-2026/
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/ys2c-2026-talks-postponed.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20261001T140000
DTEND;TZID=Europe/Paris:20261001T173000
DTSTAMP:20260702T132811Z
CREATED:20260630T123725Z
LAST-MODIFIED:20260702T132811Z
UID:52061-1790863200-1790875800@www.bricbordeaux.com
SUMMARY:BRIC Clinical and Translational Research Meetings - 01-10-2026
DESCRIPTION:BRIC is organizing a half-day event dedicated to clinical and translational research on Thursday\, October 1\, 2026\, from 2:00 p.m. to 5:30 p.m.\, in the ground-floor lecture hall of the BBS\, in collaboration with the Bergonié Institute and the Bordeaux University Hospital.  \nThe purpose of this afternoon is to raise awareness of the role of clinical and translational research within our unit. It will feature presentations by BRIC clinicians as well as Master’s 2 students supervised by the teams\, in order to illustrate the diversity of career paths\, themes\, and approaches developed at the intersection of clinical practice and research. For younger students\, we will also present the master’s degree programs in “Cancer Biology” and “Health Innovation—Oncology Track.” \nBeyond the presentation of projects\, this meeting also aims to demonstrate how clinical and translational research can be integrated with more fundamental research\, and to foster discussions about these synergies within BRIC. \nThis half-day event will also provide an opportunity to highlight the discussions and work carried out within the Patients and Society group. \n  \nPre-program \n  \nWe hope to see many of you there for this opportunity to share and discuss. \nPlease note that this event is open to professionals and students. Patients and members of the general public are welcome to attend other events\, which you can find on our dedicated website: https://patients-recherche.bricbordeaux.com/  \n  \nBest regards\, \nSamuel Amintas and Véronique Vendrely\, on behalf of the Scientific Strategy Committee \n 
URL:https://www.bricbordeaux.com/en/event/bric-clinical-and-translational-research-meetings-01-10-2026/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/06/journee-recherche-clinique-bric-01-10-2026.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20261028
DTEND;VALUE=DATE:20261031
DTSTAMP:20260904T145007Z
CREATED:20260320T144426Z
LAST-MODIFIED:20260904T145007Z
UID:51270-1793145600-1793404799@www.bricbordeaux.com
SUMMARY:Enlight NetCARE days - 28-30 oct 2026 Bordeaux
DESCRIPTION:This international conference will mark the second edition of ENLIGHT Cancer Days\, following the first edition held in Bordeaux in September 2023\, which brought together participants from five European universities. \nThe 2026 edition will be the highlight of the NetCare network (Network for Cancer Research and Education)\, which has recently received funding and been recognized as a new ETN (European Thematic Network) within the ENLIGHT alliance\, which brings together 10 leading European universities. This alliance brings together the University of the Basque Country (Spain)\, the University of Bern (Switzerland)\, Comenius University in Bratislava (Slovakia)\, the University of Bordeaux (France)\, the University of Galway (Ireland)\, the University of Ghent (Belgium)\, the University of Göttingen (Germany)\, the University of Groningen (Netherlands)\, the University of Tartu (Estonia)\, and Uppsala University (Sweden). \n  \nThe BRIC unit is organizing this international conference on the topic of cancer in the heart of Bordeaux from October 28 to 30\, 2026\, at the Agora du Haut Carré in Talence \nThe scientific program will cover a range of innovative topics\, incorporating basic\, translational\, and clinical research. \nThe main goal of the conference is to strengthen scientific collaboration in the long term by fostering greater interaction among partner teams. \nRegistration and abstract submissions for poster and flash presentations are now open! \nRegistrations \n  \nDeadlines: \nAbstract submissions for posters and flash presentations: August 31\, 2026\, extended to September 11\, 2026\nRegistration : 30-09-2026 \n  \nContact : enlight.netcare-bordeaux@diff.u-bordeaux.fr \n  \n \n  \n 
URL:https://www.bricbordeaux.com/en/event/enlight-netcare-days-28-30-oct-2026-bordeaux/
LOCATION:Agora du Haut Carré – Université de Bordeaux\, 43 rue Pierre Noailles\, Talence\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2026/03/vignette-enlight-netcare-days-oct-2026-registrations-opened.jpg
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