BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Bordeaux Institute of Oncology - ECPv6.17.3.1//NONSGML v1.0//EN CALSCALE:GREGORIAN METHOD:PUBLISH X-WR-CALNAME:Bordeaux Institute of Oncology X-ORIGINAL-URL:https://www.bricbordeaux.com/en/ X-WR-CALDESC:Events for Bordeaux Institute of Oncology REFRESH-INTERVAL;VALUE=DURATION:PT1H X-Robots-Tag:noindex X-PUBLISHED-TTL:PT1H BEGIN:VTIMEZONE TZID:Europe/Paris BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20220327T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20221030T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20230326T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20231029T010000 END:STANDARD BEGIN:DAYLIGHT TZOFFSETFROM:+0100 TZOFFSETTO:+0200 TZNAME:CEST DTSTART:20240331T010000 END:DAYLIGHT BEGIN:STANDARD TZOFFSETFROM:+0200 TZOFFSETTO:+0100 TZNAME:CET DTSTART:20241027T010000 END:STANDARD END:VTIMEZONE BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231207T100000 DTEND;TZID=Europe/Paris:20231207T130000 DTSTAMP:20231120T145013Z CREATED:20231120T145013Z LAST-MODIFIED:20231120T145013Z UID:45020-1701943200-1701954000@www.bricbordeaux.com SUMMARY:Thesis defense Sergio de Hita DESCRIPTION:Sergio de Hita\, team 08 BIOGO will present his thesis in genetics on Thursday December 7 at 10am\, amphi Denucé campus Victoire. \nTitle : MAPK modulation and its implications in KRAS mutant lung adenocarcinoma. \nThesis co-supervised by David Cappellen (BRIC\, team 8) and David Santamaria – Salamanca Cancer Research Center (CIC-IBMCC)\, Team Novel RAS regulators in cancer & homeostasis \nNotice of defense at this link URL:https://www.bricbordeaux.com/en/event/thesis-defense-sergio-de-hita/ LOCATION:Amphi Dénucé\, Victoire\, 3ter Pl. de la Victoire\, Bordeaux\, 33000\, France CATEGORIES:Meetings,Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/11/soutennace-de-these-sergio-de-hita.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231208T143000 DTEND;TZID=Europe/Paris:20231208T170000 DTSTAMP:20231121T133512Z CREATED:20231121T090019Z LAST-MODIFIED:20231121T133512Z UID:45041-1702045800-1702054800@www.bricbordeaux.com SUMMARY:Thesis defense Mélanie Moreau DESCRIPTION:Mélanie Moreau\, team 03 – Liver Cancers and Tumor Invasion\, will present her thesis on Friday\, December 8\, 2:30 p.m. in the CGFB amphitheatre\, 146 rue Leo Saignat\, Bordeaux. \nsupervisor: Frédéric Saltel \n  \nInvolvement of invadosomes in tumor invasion through two examples\, Ruvbl2 in molecular organization and DDR2 in angiogenesis \nMetastasis is the main cause of death in cancer patients. Around 90% of all deaths are attributed to tumor invasion. Invadosomes are F-actin structures known to be involved in the metastatic process\, particularly through their function of extracellular matrix degradation. This promotes the migration of cells into the extracellular matrix\, and enables them to cross anatomical barriers such as vessel walls. In this thesis\, I focused on the role of Ruvbl2 in invadosome formation and activity. Ruvbl2 is an AAA+ATPase\, member of the R2TP complex\, which plays a chaperoning role in the formation of big protein complexes and is found enriched in rosette-shaped invadosomes. I have contributed to demonstrating that Ruvbl2 is involved in the process of invadosome formation and\, more specifically\, in the organization of these structures into rosettes\, via the R2TP complex. This complex protects several proteins involved in invadosome formation\, including Fak\, from autophagic degradation. I was also interested in the regulation of angiogenesis via invadosome formation and activity in endothelial cells. I demonstrated that\, in the presence of type I fibrillar collagen\, proteasome interacts with DDR2 receptor and negatively regulates invadosome activity. Proteasome inhibition drastically increases invadosome degradation activity. This inhibition stimulates DDR2 activation\, mainly by Src. These results underline the importance of a balance between Src and proteasome activity to avoid cell death. Finally\, this work provides a better understanding of mechanisms of induction\, formation and regulation of invadosomes. It highlights a set of proteins and functions linked to these invasive structures that could be pharmacologically targeted to inhibit metastasis. \n \nKey words : Cancer – Invadosomes – Invasion – Ruvbl2 – R2TP – DDR2 URL:https://www.bricbordeaux.com/en/event/thesis-defense-melanie-moreau/ LOCATION:salle de conférence CGFB – site Carreire\, 146 rue Leo Saignat\, Bordeaux\, 33000\, France CATEGORIES:Meetings,Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/11/soutenance-de-these-melanie-moreau-1.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231214T103000 DTEND;TZID=Europe/Paris:20231214T113000 DTSTAMP:20231121T141359Z CREATED:20231121T135900Z LAST-MODIFIED:20231121T141359Z UID:45053-1702549800-1702553400@www.bricbordeaux.com SUMMARY:Corinne Bousquet seminar\, invited by Team 3 BRIC DESCRIPTION:Corinne Bousquet \nCentre de Recherches en Cancérologie de Toulouse (CRCT)\nTeam Leader MICROPANC (Microenvironment & Therapeutic Resistance in Pancreatic Adenocarcinoma) \nTitle : “Cancer-associated fibroblast heterogeneity underlying pancreatic cancer aggressiveness.” \nThursday\, December 14\, 10:30 a.m. – amphi BBS – 2 rue Dr Hoffmann Martino Bordeaux. \nSeminar open to the scientific community\, organized as part of Corinne Bousquet‘s visit to Léa Normand’s thesis jury\, team 03 – Liver Cancers and Tumor Invasion. URL:https://www.bricbordeaux.com/en/event/corinne-bousquet-seminar-invited-by-team-3-bric/ LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux CATEGORIES:Meetings,Scientific seminars ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/11/seminaire-corinne-bousquet-bric.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231214T141500 DTEND;TZID=Europe/Paris:20231214T170000 DTSTAMP:20231207T155834Z CREATED:20231207T155239Z LAST-MODIFIED:20231207T155834Z UID:45132-1702563300-1702573200@www.bricbordeaux.com SUMMARY:Léa Normand thesis defense DESCRIPTION:Léa Normand\, Team 03 – Liver Cancers and Tumor Invasion\, will submit her thesis in Cell Biology and Pathophysiology. \nThursday\, December 14\, 2:15pm\, BBS lecture hall\, 2 rue du Dr Hoffmann Martinot\, Bordeaux \nTitle : “Implication du collagène dans la dégradation\, la migration et l’invasion tumorale.” \nThesis director : Frédéric Saltel \nNotice of defense available at this link. \nTaking advantage of her presence on the thesis jury\, we invite Madame Corinne Bousquet – Centre de Recherches en Cancérologie de Toulouse (CRCT) – to give a lecture on the same day at 10:30 am. All the info at this link. URL:https://www.bricbordeaux.com/en/event/lea-normand-thesis-defense/ LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux CATEGORIES:Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/12/soutenance-de-these-lea-normand-illustration.png END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231215T110000 DTEND;TZID=Europe/Paris:20231215T120000 DTSTAMP:20231117T155825Z CREATED:20231117T155825Z LAST-MODIFIED:20231117T155825Z UID:45021-1702638000-1702641600@www.bricbordeaux.com SUMMARY:Seminar Prof. Pierre-Emmanuel Rautou\, invited by Clotilde Billottet DESCRIPTION:As part of the seminars organized by the Biological and Medical Sciences Department (SBM) at Bordeaux University\, Prof. Pierre-Emmanuel Rautou has been invited by Clotilde Billottet (Team 03 – Liver Cancers and Tumor Invasion). \nPierre-Emmanuel Rautou\, Center for Inflammation Research\, UMR 1149 Inserm\, Paris \nFriday\, December 15\, 11 a.m.\, BBS amphitheatre\, 2 rue Dr Hoffmann Martinot Bordeaux \n“Les vésicules extracellulaires\, des biomarqueurs et vecteurs d’information dans la cirrhose” \nProf. Pierre-Emmanuel Rautou (MD\, PhD) is a clinical specialist in Hepatology with a PhD in vascular biology. He is Professor of Hepatology at the University of Paris and Hôpital Beaujon (Clichy\, France) since 2016. He is the head of the splanchnic hemodynamic laboratory at Beaujon Hospital (Clichy\, France) since 2012. He is also leading an INSERM team at the Paris Research Center on Inflammation (INSERM Unit 1149) since 2019. His research is dedicated to the study of the role of vessels in liver diseases. On the clinical side\, he is interested in primary vascular liver diseases (Budd-Chiari syndrome\, extrahepatic portal vein thrombosis and obstruction of intrahepatic portal veins)\, as well as in vascular involvement in cirrhosis development and complications. On the basic side\, his objectives are to identify the role of extracellular vesicles and of autophagy in liver diseases. \nAbstract :\nExtracellular vesicles are membrane-bound vesicles containing proteins\, lipids\, RNAs and microRNAs. They can originate from both healthy and stressed cells\, and provide a snapshot of the cell of origin in physiological and pathological circumstances. Various processes that may give rise to the release of extracellular vesicles occur in liver diseases\, including hepatocyte apoptosis\, hepatic stellate cell activation\, liver innate immune system activation\, systemic inflammation\, and organelle dysfunction (mitochondrial dysfunction and endoplasmic reticulum stress). Numerous studies have therefore investigated the potential role of extracellular vesicles as biomarkers in liver diseases and particularly in cirrhosis. But extracellular vesicles are also vectors of information between cells and organs in the setting of cirrhosis. This lecture will cover both aspects. URL:https://www.bricbordeaux.com/en/event/seminar-prof-pierre-emmanuel-rautou-invited-by-clotilde-billottet/ LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux CATEGORIES:Meetings,Scientific seminars ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/11/illustration.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231215T140000 DTEND;TZID=Europe/Paris:20231215T170000 DTSTAMP:20231215T155554Z CREATED:20231215T155554Z LAST-MODIFIED:20231215T155554Z UID:45219-1702648800-1702659600@www.bricbordeaux.com SUMMARY:Camille Dantzer thesis defense DESCRIPTION:Camille Dantzer\, team 03 – Liver Cancers and Tumor Invasion will submit its thesis in Cell Biology and Pathophysiology. \nFriday\, December 15\, 2pm BBS amphitheatre\, 2 rue du Dr Hoffmann Martinot\, Bordeaux \nTitle : « Implication des exosomes et des chimiokines dans l’évasion immunitaire des carcinomes hépatocellulaires mutés pour la ßcaténine. » \nThesis work directed by Ms. Clotilde BILLOTTET \nNotice of defense available at this link. URL:https://www.bricbordeaux.com/en/event/camille-dantzer-thesis-defense/ CATEGORIES:Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/12/soutenance-de-these-camille-dantzer.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231215T150000 DTEND;TZID=Europe/Paris:20231215T170000 DTSTAMP:20231212T140750Z CREATED:20231212T140750Z LAST-MODIFIED:20231212T140750Z UID:45220-1702652400-1702659600@www.bricbordeaux.com SUMMARY:Rarahu Magaut thesis defense DESCRIPTION:Defense of Rarahu Magaut‘s thesis in Cell Biology and Physiopathology (Team 1 – Tumor and Vascular Biology Laboratory). \nFriday 15/12\, 9 a.m. (Montreal time)\, or 3 p.m. in Bordeaux : \nZoom link on request \nGoodman Cancer Institute (salle 501)\, 1160 Avenue des Pins Ouest H3A 1A3\, Montréal\, Québec\, CANADA \nTitle : PRL2/PTP4A2\, un modulateur des fonctions lymphatiques et de l’inflammation \nThesis co-supervised by Andreas Bikfalvi (team 1) and Michel Tremblay (Goodman Cancer Institute\, McGill University\, Montreal) \nNotice of defense at this link URL:https://www.bricbordeaux.com/en/event/rarahu-magaut-thesis-defense/ CATEGORIES:Meetings,Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/12/soutenance-rarahu-magaut-1.jpg END:VEVENT BEGIN:VEVENT DTSTART;TZID=Europe/Paris:20231221T140000 DTEND;TZID=Europe/Paris:20231221T170000 DTSTAMP:20231218T134524Z CREATED:20231218T134524Z LAST-MODIFIED:20231218T134524Z UID:45235-1703167200-1703178000@www.bricbordeaux.com SUMMARY:Joudi El Mir thesis defense DESCRIPTION:Defense of thesis in Cell Biology and Physiopathology by Joudi El Mir\, team 05 – Translational Research In Oncodermatology and Orphan skin diseases (TRIO2). \nTitle : Modélisation des Anomalies Pigmentaires chez les Patients atteints de Xeroderma Pigmentosum-C en utilisant Xenopus laevis comme modèle in vivo.\nThesis co-supervised by Hamid-Reza REZVANI (BRIC team 05) and Hussein FAYYAD-KAZAN (Lebanese university)\nDefense scheduled for Thursday\, December 21\, 2023 at 2:00 p.m. \nCGFB\, Centre de Génomique Fonctionelle Bordeaux\,\n146 Rue Léo Saignat\, 33076 Bordeaux cedex \nNotice of defense at this link URL:https://www.bricbordeaux.com/en/event/joudi-el-mir-thesis-defense/ LOCATION:salle de conférence CGFB – site Carreire\, 146 rue Leo Saignat\, Bordeaux\, 33000\, France CATEGORIES:Scientific seminars,Thesis defenses ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2023/12/soutenance-de-these-joudi-el-mir.jpg END:VEVENT END:VCALENDAR