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X-WR-CALNAME:Bordeaux Institute of Oncology
X-ORIGINAL-URL:https://www.bricbordeaux.com/en/
X-WR-CALDESC:Events for Bordeaux Institute of Oncology
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240604T140000
DTEND;TZID=Europe/Paris:20240604T150000
DTSTAMP:20240531T132209Z
CREATED:20240531T132209Z
LAST-MODIFIED:20240531T132209Z
UID:46837-1717509600-1717513200@www.bricbordeaux.com
SUMMARY:SBM Department Seminar - Sigve Nakken
DESCRIPTION:Sigve Nakken\nInstitute for Cancer Research at Oslo University Hospital\, Norvège \n📆 4 june\, 2pm \n📌 IBGC (Carreire 146 rue Leo Saignat\, Bordeaux) \nSeminar organized by the Department of Biological and Medical Sciences (SBM) at the University of Bordeaux. \nA suite of computational frameworks to support precision cancer medicine \nCancer precision medicine is an approach to cancer treatment that tailors medical care to the individual characteristics of each patient and their tumor. A cornerstone of this approach is the use of high-throughput genomic profiling technologies for a deep characterization of the molecular features of tumor samples. The diversity and complexity of molecular read-outs\, combined with a rapidly evolving landscape of clinically actionable targets\, poses significant requirements for advanced data interpretation tools. In this talk\, I will present molecular data interpretation frameworks that we are actively developing to address the N-of-1 analytical challenge in precision oncology\, that is to highlight treatment opportunities for each complex cancer case in light of existing knowledge and large-scale reference datasets. Herein\, I will describe challenges and solutions with respect to molecular data integration and harmonization\, the adoption of standards for evaluating the clinical significance of genomic aberrations\, as well as the identification of relevant biomarker-guided clinical trials.     \nBio \nSigve Nakken works as a scientist at the Institute for Cancer Research at Oslo University Hospital\, Norway\, with affiliation to the Centre for Cancer Cell Reprogramming (CanCell)\, a Centre of Excellence at the University of Oslo. In addition\, he holds an Adjunct Professor position at the Department of Informatics\, University of Oslo. Nakken’s main interests are tool development for clinical interpretation of cancer genomes\, mechanisms and impact of DNA variation in cancer (soma and germline)\, and knowledge integration for precision cancer medicine. He has a background from computer science (MSc) and computational biology (PhD)\, and extensive experience with analysis of data from high-throughput sequencing technologies. He is the lead developer of multiple bioinformatics tools used in high-throughput cancer biology.
URL:https://www.bricbordeaux.com/en/event/sbm-department-seminar-sigve-nakken/
LOCATION:salle de conférence IBGC – Carreire\, 146 rue Leo Saignat\, Bordeaux\, 33000\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/png:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/05/seminaire-sigve-nakken.png
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240605T140000
DTEND;TZID=Europe/Paris:20240605T170000
DTSTAMP:20240527T074827Z
CREATED:20240524T145806Z
LAST-MODIFIED:20240527T074827Z
UID:46735-1717596000-1717606800@www.bricbordeaux.com
SUMMARY:HDR defense of François Moisan
DESCRIPTION:François Moisan\, researcher in Team 05 – Translational research in cutaneous oncology and rare skin diseases (TRIO2) will present his HDR (Habilitation to Supervise Research) on Wednesday June 5 at 2pm\, BBS amphitheater. \nSubject: Cellular and molecular mechanisms of the antitumor response to propranolol in vascular tumors. \nFrançois Moisan works on cutaneous vascular tumors and their therapy. The serendipity discovery of the effectiveness of propranolol on infantile hemangiomas (IH) in the team in 2008 led him\, upon his return from the USA in 2013\, to work on this mechanism of action. This work revealed that (1) IH is a tumor rich in norepinephrine (NE)\, one of the natural ligands of the beta-adrenergic pathway\, the expected target of treatment. (2) The cells making up the tumor (endothelial cells and pericytes) are capable of producing and secreting NE. (3) Anti-angiogenic effect is obtained through a competitive inhibition of NE by propranolol in vitro. He was also able to demonstrate (4) a third cell type which is key in the pathogenesis and response to propranolol: the telocyte. This stromal cell involved in cellular communication\, architecture and tissue remodeling\, including in the skin\, is revealed here (5) to overexpress aquaporin-1 modulated by propranolol. The development of in vitro coculture models relevant to this study makes it possible to explore the cellular and molecular mechanisms involved in the growth and regression of hemangiomas\, with the aim of identifying new therapeutic pathways for tumors and vascular abnormalities. The group he formed within the oncodermatology team (TRIO2) is also interested in angiomas associated with GNAQ mutations and angiosarcoma-type cancers.         \n 
URL:https://www.bricbordeaux.com/en/event/hdr-defense-of-francois-moisan/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/05/soutenance-hdr-f.-moisan.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240610T100000
DTEND;TZID=Europe/Paris:20240610T110000
DTSTAMP:20240528T102518Z
CREATED:20240527T100339Z
LAST-MODIFIED:20240528T102518Z
UID:46744-1718013600-1718017200@www.bricbordeaux.com
SUMMARY:BRIC invited seminar: Pierre Chymkowitch
DESCRIPTION:Our unit invites Pierre Chymkowitch\,Associate Professor – Group leader: Transcriptional Regulation Of Cell Fate (Department of Biosciences – University of Oslo – Norway) to present its work at a special seminar. \n“Understanding the Role of Mitotic Chromosome Condensation and SUMOylation in Maintaining Cellular Identity and Homeostasis”. \n📆 Monday June 10 – 10 am\n📌 Bâtiment Bordeaux Biologie Santé – BBS\, 2 rue Dr Hoffmann Martinot\, 33000 Bordeaux\nzoom link on request (sarah.lesjean@inserm.fr)\n \n  \nAbstract:\nPreservation of gene expression patterns that define cellular identity is essential to perpetuate cellular lineages and preserve homeostasis. During this presentation I will feature published and unpublished data indicating how transcriptional and epigenetic identities are conserved throughout cell division and differentiation. Mitotic entry correlates with the condensation of the chromosomes\, changes in histone modifications\, exclusion of transcription factors from DNA\, and the broad downregulation of transcription. We found that preventing one chromosome to condense during mitosis causes it to fail resetting transcription. Rather\, in the following interphase\, the affected chromosome contains unusually high levels of the transcription machinery\, resulting in abnormally high gene expression levels\, including various transcription factors. This subsequently causes the activation of inducible transcriptional programs in trans\, even in the absence of the relevant stimuli. Thus\, mitotic chromosome condensation exerts stringent control on interphase gene expression to ensure the maintenance of cell identity across cell divisions (1). We used adipogenesis as a model to find that SUMOylation of chromatin-bound proteins ensures the precision of gene expression and transcription factor dynamics during differentiation (2). However\, the molecular mechanisms by which SUMOylation orchestrates the rewiring of transcriptional programs during initiation of differentiation remains to be established. Our unpublished data indicate that transient\, pharmacological inhibition of SUMOylation in human preadipocytes is sufficient to prime and activate specific enhancers and transcription factors. This causes irreversible hypertranscription of adipogenic genes\, leading to excessive fat accumulation. Given that epigenetic and transcriptional regulators are major SUMO targets\, we propose that SUMOylation maintains a chromatin landscape in undifferentiated cells\, which is critical to preserving the epigenetic fate of mature adipocytes\, protecting against unrestricted adipogenic transcription. This implies that the inherent adipogenic capacity of human adipose stem cells may be tied to SUMOylation and suggests an epigenetic basis for the inter-individual variability in fat accumulation. Using adipogenesis as a paradigm to uncover new molecular pathways by which SUMOylation sustains epigenetic fates\, we expect to contribute to a broader understanding of how transitory disruptions in epigenetic regulation induce stable homeostatic shifts and lead to disease\, like obesity and cancer (3).  \n\nRamos-Alonso\, L. et al. Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase. Proc Natl Acad Sci U S A 120\, e2210593120 (2023).   https://doi.org:10.1073/pnas.2210593120\nZhao\, X. et al. Waves of sumoylation support transcription dynamics during adipocyte differentiation. Nucleic Acids Res 50\, 1351-1369 (2022).   https://doi.org:10.1093/nar/gkac027\nParreno\, V. et al. Transient loss of Polycomb components induces an epigenetic cancer fate. Nature (2024).   https://doi.org:10.1038/s41586-024-07328-w\n\n  \nBio: \nI obtained a PhD from the University of Strasbourg in 2008. My research in the group of Jean-Marc Egly\, at the IGBMC\, was focused on revealing the origin of gene expression defects in patients with rare genetic disorders like Xeroderma pigmentosum (1). I then moved to Norway at the Dept. of Microbiology at Oslo Univ. Hospital. For the next eight years\, I continued my research in the group of JM. Enserink on gene regulation in the model organism Saccharomyces cerevisiae. The first four years were dedicated to revealing mechanisms that synchronize cell-cycle progression and gene expression (2). In the next four years I strated investigating the mechanisms regulated by the Small Ubiquitin-like Modifier SUMO at the chromatin level during adaptive response to stress (3) and started exploring the perpetuation of epigenetic and transcriptional memory throw-out mitosis (4). Next\, I started my group at Oslo Univ. Hospital and was appointed Associate Professor at the University of Oslo\, where I have been working since 2020. Our focus is unraveling the mechanisms supporting epigenetic and transcription fidelity (5) during cellular differentiation\, with a particular focus on how the SUMOylation pathway supports cellular fate (6\,7). References:  \n\nChymkowitch\, P.\, Le May\, N.\, Charneau\, P.\, Compe\, E. & Egly\, J. M. The phosphorylation of the androgen receptor by TFIIH directs the ubiquitin/proteasome process. EMBO J 30\, 468-479\n(2011).  https://doi.org:10.1038/emboj.2010.337\nChymkowitch\, P. et al. Cdc28 kinase activity regulates the basal transcription machinery at a subset of genes. Proc Natl Acad Sci U S A 109\, 10450-10455 (2012).   https://doi.org:10.1073/pnas.1200067109\nChymkowitch\, P. et al. TORC1-dependent sumoylation of Rpc82 promotes RNA polymerase III assembly and activity. Proc Natl Acad Sci U S A 114\, 1039-1044 (2017).   https://doi.org:10.1073/pnas.1615093114\nKruitwagen\, T.\, Chymkowitch\, P.\, Denoth-Lippuner\, A.\, Enserink\, J. & Barral\, Y. Centromeres License the Mitotic Condensation of Yeast Chromosome Arms. Cell 175\, 780-795 e715 (2018).  https://doi.org:10.1016/j.cell.2018.09.012\nRamos-Alonso\, L. et al. Mitotic chromosome condensation resets chromatin to safeguard transcriptional homeostasis during interphase. Proc Natl Acad Sci U S A 120\, e2210593120 (2023).   https://doi.org:10.1073/pnas.2210593120\nZhao\, X. et al. Waves of sumoylation support transcription dynamics during adipocyte differentiation. Nucleic Acids Res 50\, 1351-1369 (2022).   https://doi.org:10.1093/nar/gkac027\nBjune\, J.-I. et al. Mechanisms of the FTO locus association with obesity: Irx3 controls a sumoylation-dependent switch between adipogenesis and osteogenesis. bioRxiv\,\n2023.2010.2017.562662 (2023).  https://doi.org:10.1101/2023.10.17.562662
URL:https://www.bricbordeaux.com/en/event/bric-invited-seminar-pierre-chymkowitch/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/05/invited-bric-seminar-pierre-chymkowitch-10-10-2024.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240612T140000
DTEND;TZID=Europe/Paris:20240612T150000
DTSTAMP:20240610T133646Z
CREATED:20240531T133015Z
LAST-MODIFIED:20240610T133646Z
UID:46836-1718200800-1718204400@www.bricbordeaux.com
SUMMARY:SBM Department Seminar - Maxime Mahout
DESCRIPTION:Maxime Mahout \n“Décomposition des flux métaboliques des cellules en prolifération en Modes Elémentaires de Flux (EFMs). Application à la cellule cancéreuse moyenne” \n  \n📆 Wednesday June 12 at 2pm \n📌 ATTENTION ROOM CHANGE: amphitheatre in the BBS building\, 2 rue Dr Hoffmann Martinot\, Bordeaux\n \nSeminar organized by the Department of Biological and Medical Sciences (SBM) at the University of Bordeaux.
URL:https://www.bricbordeaux.com/en/event/sbm-department-seminar-maxime-mahout/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/05/seminaires-departement-sbm.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240613T120000
DTEND;TZID=Europe/Paris:20240613T130000
DTSTAMP:20240614T081857Z
CREATED:20240425T161311Z
LAST-MODIFIED:20240614T081857Z
UID:46427-1718280000-1718283600@www.bricbordeaux.com
SUMMARY:BRIC technology seminar - Promega
DESCRIPTION:Our Technologies Group organizes this seminar with Promega \n  \nEnhancing your Research using Bioluminescent Technologies \nPresentation by Promega France :\nLudivine Sinzelle\, Key account Manager\, Responsable Grands Comptes Sud-Ouest\nFlorian Mignot\, Technical Support for Drug Discovery Solutions \nDetails in the poster. \n \n  \n  \n 
URL:https://www.bricbordeaux.com/en/event/bric-technology-seminar-promega/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/04/vignette-bric-techno-meeting-promega-bis.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240614T143000
DTEND;TZID=Europe/Paris:20240614T170000
DTSTAMP:20240613T145205Z
CREATED:20240528T123755Z
LAST-MODIFIED:20240613T145205Z
UID:46756-1718375400-1718384400@www.bricbordeaux.com
SUMMARY:Thesis defense Alexia Calovoulos
DESCRIPTION:Alexia Calovoulos\, team 6 MIRCADE (Methods and Innovations for the Research in Pediatric Cancers) will present her thesis in Cell Biology and Pathophysiology.. \nThesis supervisor Christophe Grosset. \nTitle : “Study of the three-dimensional organization of hepatoblastoma tissues by volumetric imaging: Link to the Wnt/beta-catenin signaling pathway?” \n📆 Friday\, June 14 at 2:30 p.m. \nModule 2.6 batiment CROUS 2e étage (Carreire)\n146 rue Léo Saignat Bordeaux \nNotice of defense with abstract at this link \nThesis funded by the Région Nouvelle-Aquitaine and the Eva pour la Vie and Sphères associations.
URL:https://www.bricbordeaux.com/en/event/thesis-defense-alexia-calovoulos/
CATEGORIES:Meetings,Scientific seminars,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/05/soutenance-de-these-alexia-calovoulos.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240617
DTEND;VALUE=DATE:20240618
DTSTAMP:20240404T140706Z
CREATED:20240404T140706Z
LAST-MODIFIED:20240404T140706Z
UID:46420-1718582400-1718668799@www.bricbordeaux.com
SUMMARY:Science\, society and values symposium
DESCRIPTION:Science\, society and values symposium at Agora du Haut-Carré\, Talence. \nPr Andreas Bikfalvi (team1) is part of the organization of this symposium. \nFree admission with registration : https://form.jotform.com/240513496727360 \nProgram: \nSYMPOSIUM SCIENCE-SOCIETY VALUES-PROGRAM-final
URL:https://www.bricbordeaux.com/en/event/science-society-and-values-symposium/
LOCATION:Agora du Haut Carré – Université de Bordeaux\, 43 rue Pierre Noailles\, Talence\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/04/afiiche-symposium-science-societe-valeurs-juin-2024.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20240617T133000
DTEND;TZID=Europe/Paris:20240617T170000
DTSTAMP:20240628T133415Z
CREATED:20240607T095518Z
LAST-MODIFIED:20240628T133415Z
UID:46950-1718631000-1718643600@www.bricbordeaux.com
SUMMARY:HDR defense Sandrine Poglio
DESCRIPTION:Sandrine Poglio\, univ. lecturerTeam 05 – Translational Research In Oncodermatology and Orphan skin diseases (TRIO2). will defend her HDR (Habilitation à Diriger la Recherche) on Monday June 17 at 1:30pm in the amphitheatre of the Centre de Génomique Fonctionnelle de Bordeaux\, site Carreire Université de Bordeaux (146 rue Leo Saignat). \n“Des cellules souches hématopoïétiques aux lymphocytes T tumoraux”  \nJury members: \nPr Katia Boniface\, PR\, Université de Bordeaux\nDr Erika Brunet\, DR INSERM\, Institut Imagine\, Paris\nDr Françoise PFLUMIO\, DR INSERM\, Laboratoire LSHL\, CEA-INSERM\, Fontenay-aux Roses\nDr Laurent Genestier\, DR INSERM\, CIRI\, Lyon\nPr Nicolas Ortonne\, PU-PH\, IMRB\, APHP\, Département de Pathology Hôpital Henri Mondor\, Créteil\nPr Jean-Philippe Merlio\, PU-PH\, CHU et Université de Bordeaux
URL:https://www.bricbordeaux.com/en/event/hdr-defense-sandrine-poglio/
LOCATION:salle de conférence CGFB – site Carreire\, 146 rue Leo Saignat\, Bordeaux\, 33000\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/06/soutenance-hdr-sandrine-poglio.jpg
END:VEVENT
BEGIN:VEVENT
DTSTART;VALUE=DATE:20240620
DTEND;VALUE=DATE:20240621
DTSTAMP:20240617T125331Z
CREATED:20240216T155252Z
LAST-MODIFIED:20240617T125331Z
UID:45841-1718841600-1718927999@www.bricbordeaux.com
SUMMARY:3D Biology Models Day June 20\, 2024
DESCRIPTION:Christine Varon\, head of team 04 (Digestive cancers associated with Helicobacter infection\, cancer stem cells and therapeutic strategies) and her scientific colleagues from Bordeaux are organizing a day of 3D models in biology. \n📆 June 20\, 2024 \n📌Domaine du Haut Carré \n👉 Free registration and abstract submission at this link:https://3dbio.sciencesconf.org/ \nThe deadline for registration and abstract submission has been extended to June 6. \nGreat news\, in addition to our great local speakers\, we will have the pleasure to welcome Xavier Gidrol (CEA Grenoble)\, one of the project leader of the recently granted PEPR MEDOOC! \nThe focus of the day is on three-dimensional cellular models developed in vitro for biology and medicine. These models\, which include organoids\, spheroids\, organs-on-a-chip and bioprinted tissues\, are currently undergoing exponential development\, thanks in particular to the coincidence between advances in stem cell biology and technologies enabling the topology and composition of the tissue microenvironment to be controlled. As well as being an alternative to animal models\, these models are of major interest for understanding developmental mechanisms\, disease modeling\, drug screening\, regenerative medicine and personalized medicine. This research is intrinsically interdisciplinary\, requiring the collaboration of biologists\, physicians\, physicists\, chemists and engineers.    \nThe aim of this first edition is to bring together people already using or wishing to develop these models\, to share their current or future projects. The day will enable the various local players to interact with each other\, pool their efforts and promote exchanges and collaborations.  \nPractical information \nThe day will be organized around thematic sessions\, with one invited paper and short communications (8 min + 2 min questions) per session. Coffee and lunch breaks will be accompanied by poster sessions. Abstracts for short communications and/or posters will be accepted from 15/02/2024.   \nOn-site only \nOrganizing committee  \nHugo De-Oliveira (Biotis) – Isabelle Dupin (CRCTB) – Elise Maurat (CRCTB) – Matthieu Raoux (CBMN) – Gaëlle Recher (LP2N) – Vincent Studer (IINS) – Christine Varon (BRIC)
URL:https://www.bricbordeaux.com/en/event/3d-biology-models-day-june-20-2024/
LOCATION:Agora du Haut Carré – Université de Bordeaux\, 43 rue Pierre Noailles\, Talence\, France
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2024/02/vignette-1.jpg
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