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X-WR-CALDESC:Events for Bordeaux Institute of Oncology
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DTSTART;TZID=Europe/Paris:20251113T100000
DTEND;TZID=Europe/Paris:20251113T113000
DTSTAMP:20251031T135221Z
CREATED:20251031T135221Z
LAST-MODIFIED:20251031T135221Z
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SUMMARY:Graduate program Cancer Biology invited seminar - Raul V. DURAN
DESCRIPTION:The lecturers and professors of the Graduate Program in Cancer Biology invite Raul V. Duran to give a lecture in Bordeaux on Thursday\, November 13\, from 10:00 a.m. to 11:30 a.m. in the conference room of the BBS building\, 2 rue du Dr Hoffmann Martinot.\nRaul Duran will be available on Wednesday\, November 12\, during the morning\, to talk with researchers who wish to meet him.\nContact: jose-eduardo.gomes@u-bordeaux.fr\n\n\nRaul V. Duran\nSpanish National Research Council (CSIC) – Séville\nGroup Leader of the Group of Metabolism and Cell Signaling\n \n“Metabolic imbalance as a therapeutic strategy in cancer.” \n  \nAbstract \nDuring last years\, a great amount of effort has been dedicated to elucidate the crosstalk between cellular metabolic and bioenergetic flows with signaling processes\, and how this interaction contributes to coordinate the growth and homeostasis of cells and tissues. Particularly\, how these interaction mechanisms are deregulated in cancer at the molecular and cellular level is a matter of intense research\, with the aim of using this knowledge to propose new therapeutic alternatives. Our research has established the processes of interaction between the metabolism of the amino acid glutamine\, the most abundant in human blood and the most important from an energetic point of view for cells\, with cell signaling via the mTOR pathway\, a protein complex essential in the regulation of cell growth and metabolism\, and autophagy. More recently\, we focused our research on metabolic adaptation associated to therapy resistance in glioblastoma (GBM)\, one of the tumor types with the poorest survival outcomes. This work resulted in the identification of FGFR1 pathway as a major regulator of the signaling and metabolic rewiring associated with temozolomide (TMZ) resistance in GBM. Hence\, we described a mechanism of resistance that operates at two major levels. First\, a p53-mediated regulation of cell cycle inducing cell cycle arrest to allow DNA repair in response to TMZ. And second\, a complete metabolic rewiring promoting lipid catabolism and preventing lipid peroxidation. Both the p53-mediated response and the metabolic adaptation are controlled by FGFR1\, as inhibition of the FGFR1 pathway completely abolishes this signaling and metabolic reprograming\, restoring sensitivity to TMZ. Our results also indicated a correlation of FGFR1 activity with poor prognosis in GBM patients\, and validated the treatment of TMZ in combination with FGFR1 inhibitors as an efficient strategy to induce tumor cell death in pre-clinical animal models. This data position the receptor FGFR1 as a very promising candidate for evaluation in future clinical approaches to limit the development of therapy resistance to TMZ in GBM patients. \n  \nBiosketch \nI obtained my PhD in Biochemistry at the University of Seville (Spain) in 2005 working on cellular bioenergetics. Then\, I joined the lab of Prof. Eyal Gottlieb at the Beatson Institute for Cancer Research (Glasgow\, UK) as a postdoctoral researcher to extend my expertise on broader aspects of cancer metabolism. Later\, I moved to the lab of Prof. Michael N. Hall at the Biozentrum (Switzerland) as a senior postdoc to study the de-regulation of cellular signaling during cancer. In 2013 I joined the Institut Européen de Chimie et Biologie (Pessac\, France) as a Group Leader (INSERM\, CR position)\, integrating my previous expertise to investigate the crosstalk between metabolism and cell signaling in cancer cells. In 2018 I moved my lab to the Centro Andaluz de Biología Molecular y Medicina Regenerativa – CABIMER\, upon my assignment as Senior Research Associate (Científico Titular) at CSIC. Since them\, I am the Group Leader of the Group of Metabolism and Cell Signaling\, and in the period 2019-2022 I was the Director of the Department of Dynamics and Cell Signaling at CABIMER. In the period 2020-2024 I was the Deputy Director of CABIMER. Currently\, I am a member of the Executive Committee of the CONEXION CANCER-CSIC\, and I serve as Associate Editor of the journal Cancer & Metabolism. Since January 2025 I serve as permanent evaluator (Gestor) of the Spanish Agency of Investigation (AEI)\, in the Biomedicine – Cancer commission.
URL:https://www.bricbordeaux.com/en/event/graduate-program-cancer-biology-invited-seminar-raul-v-duran/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/10/seminaire-invite-graduate-schhol-cancer-raul-v-duran.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251114T140000
DTEND;TZID=Europe/Paris:20251114T150000
DTSTAMP:20250729T144312Z
CREATED:20250729T144312Z
LAST-MODIFIED:20250729T144312Z
UID:49802-1763128800-1763132400@www.bricbordeaux.com
SUMMARY:Invited seminar Etienne Brecht & Aurélie Beaufrère - 2025-11-14
DESCRIPTION:Marion Bouchecareilh et Samuel Amintas from Team 8 “Genetic Biotherapies and Oncology” (BioGO) invite two speakers from Paris Cité University\, Center for Inflammation Research\, INSERM 1149\, Sinkus Team (From micro to macro in cancer development) for this seminar open to the scientific community. \n👉 Aurélie Beaufrère \nMorphological and molecular heterogeneity of hepatocellular carcinoma. \nAbstract:\nHepatocellular carcinoma is the most common primary malignant liver tumor. This tumor is highly heterogeneous\, both morphologically\, with eight histological subtypes described\, and molecularly\, with distinct transcriptomic groups described that are linked to both genomic alterations and morphological aspects. Some of these characteristics impact both prognosis and response to treatment.   \nBiography:\nCurrently an MCU-PH in the Pathology Department at Beaujon Hospital\, my hospital and research work focuses on liver pathology\, particularly liver tumors. I am developing projects on the morphological and molecular heterogeneity of primary liver tumors\, as well as multimodal artificial intelligence projects integrating pathological\, radiological\, and molecular data.  \n  \n👉 Etienne Becht \nHigh-throughput single-cell quantification of 100s of proteins using conventional flow cytometry and machine learning. \nAbstract: \nTechniques enabling single-cell resolution proteomic analyses are limited in terms of the number of cells analyzed and/or the number of proteins measured. To overcome these limitations\, we have developed “Infinity Flow\,” a method for analyzing flow cytometry data in parallel using machine learning models. By enabling the pseudo-quantification of hundreds of proteins in millions of single cells\, this technique allows for in-depth mapping of the microenvironment of complex tissues. We are currently applying it to the study of liver cirrhosis and hepatocellular carcinoma.    \nBiography: \nAs an engineer by training\, I completed a thesis in cancer immunology under the joint supervision of Hervé Fridman (PUPH) and Aurélien de Reyniès (bioinformatician) at the Cordeliers Research Center in Paris. There\, I developed MCP-counter\, a method for estimating the composition of the tumor microenvironment from the bulk transcriptome. I then completed two postdoctoral fellowships\, first at the Singapore Immunology Network on mass cytometry data analysis\, then in Seattle on parallelized flow cytometry data analysis. I then worked in R&D at Servier (Computational Medicine team) before joining Valérie Paradis’ laboratory at the hospital as an INSERM research fellow. My project focuses on profiling the hepatic microenvironment using parallelized flow cytometry and developing bioinformatics methods for analyzing cytometry data.     \n 
URL:https://www.bricbordeaux.com/en/event/invited-seminar-etienne-brecht-aurelie-beaufrere-2025-11-14/
LOCATION:Salle de conférence BBS (Bordeaux Biologie Santé)\, 2 rue Dr Hoffmann Martinot\, Bordeaux
CATEGORIES:Meetings,Scientific seminars
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/07/seminaire-e-brecht-aurelie-beaufrere-2025-11-14.jpg
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BEGIN:VEVENT
DTSTART;VALUE=DATE:20251122
DTEND;VALUE=DATE:20251123
DTSTAMP:20251124T163138Z
CREATED:20251117T182019Z
LAST-MODIFIED:20251124T163138Z
UID:50419-1763769600-1763855999@www.bricbordeaux.com
SUMMARY:Research Opens Its Doors #3 - BRIC Participation
DESCRIPTION:Our BRIC Unit participates in the SBM Department Open House \nCome and meet them! \n📆Saturday\, November 22\n🕑9h15 à 12h30 and 14h à 17h\n🚩bâtiment BBS\, 2 rue Dr Hoffmann Martinot Bordeaux (plan d’accès) \n  \nAll information about this event\n  \nMeet the scientists from our unit at these tours and workshops: \nVISITS: \n“Les supers pouvoirs des cellules” : Lamia Azzi-Martin\, Clotilde Billottet\, Arnaud Jabouille\, Martina Carlotti \n“Venez découvrir votre ADN” : Christelle Dussert\, Valérie Le Morvan\, Coralie Genevois \n“Visite d’un laboratoire de recherche” : Christine Varon\, Magalie Lalanne \n“Rencontre avec un habitant de l’estomac” : Lucie Bruhl\, Astrid Ducournau\, Jessica Massière \n“Formule 1… En rouges et Blancs” : Elodie Richard\, Valérie Lagarde \n  \nPOSTERS \nLaurence Bresson-Bepoldin et Sandrine Fedou \n  \nWORKSHOPS \nAtelier microscopie : Vanessa Desplat\, Lucie Brisson \nAtelier “Les métiers de la Recherche” : Isabelle Vigon\, Lucie Brisson \nAtelier “Les ciseaux de l’ADN” : Valérie Prouzet\, Béatrice Turcq \nAtelier “Un poisson nommé Danio” : Géraldine Siegfried\, Elodie Muzotte\, Sandrine Fedou \nAtelier pour les enfants : Lisa Renaudet-Keller \n  \nWelcome/Departure group \nLaurence Bresson Bepoldin\, Céline Léon\, Grégoire Manaud\, Lindita Lari\, Blandine Vignau\, Anne Berger\, Ana Sofia Uriola Vasquez\, Rémi Darracq\, Amandine Rousselle\, Anne Lhuillery\, Clara Jollet\, Lucie Gouret\, Melissa Correia de Oliveira\, Nina Choublier \n  \n👏Bravo à tous pour votre participation à cette journée ouverte à tous !
URL:https://www.bricbordeaux.com/en/event/research-opens-its-doors-3-bric-participation/
LOCATION:Accueil bâtiment Bordeaux Biologie Santé (BBS)\, 2 rue Dr Hoffmann Martinot\, Bordeaux\, France
CATEGORIES:Meetings
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/vignette-jpo-departement-sbm-22-11-2025.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251124T170000
DTEND;TZID=Europe/Paris:20251124T200000
DTSTAMP:20251124T155117Z
CREATED:20251124T155117Z
LAST-MODIFIED:20251124T155117Z
UID:50422-1764003600-1764014400@www.bricbordeaux.com
SUMMARY:HDR defense Audrey Michot team 9
DESCRIPTION:Audrey Michot\, MD\, PHD will defend her HDR (Habilitation à Diriger la Recherche\, or accreditation to supervise research)\, specializing in Life and Health Sciences. \nTitle : Optimisation de la prise en charge des sarcomes des tissus mous : de la prédiction des rechutes à l’innovation chirurgicale. \nMonday\, November 24\, 5 p.m. \nInstitut Bergonié 229 cours de l’Argonne 33000 Bordeaux
URL:https://www.bricbordeaux.com/en/event/hdr-defense-audrey-michot-team-9/
LOCATION:Institut Bergonié\, 229 Cours de l'Argonne\, Bordeaux\, 33076\, France
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/soutenance-hdr-audrey-michot-24-11-2025.jpg
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BEGIN:VEVENT
DTSTART;TZID=Europe/Paris:20251125T140000
DTEND;TZID=Europe/Paris:20251125T170000
DTSTAMP:20251124T163517Z
CREATED:20251124T160643Z
LAST-MODIFIED:20251124T163517Z
UID:50424-1764079200-1764090000@www.bricbordeaux.com
SUMMARY:Thesis defense by Yasmine Pobiédonoscew - Team 11
DESCRIPTION:Thesis defense in Cancer Biology. \nYasmine POBIEDONOSCEW\, team 11 \nWork supervised by Ms. Béatrice TURCQ \nIdentification des cellules souches leucémiques de la leucémie myéloïde chronique dans un nouveau modèle murin. \n  \n  \nNotice of defense with summary and jury\n  \n📆 Tuesday\, November 25\, 2 p.m. \n🚩Salle de conférence – Centre d’Appui à la Recherche et de Formation (CARF) 146 rue Léo Saignat 33000 Bordeaux
URL:https://www.bricbordeaux.com/en/event/thesis-defense-by-yasmine-pobiedonoscew-team-11/
CATEGORIES:Meetings,Thesis defenses
ATTACH;FMTTYPE=image/jpeg:https://cdn-bricbordeaux.onlc.eu/wp-content/uploads/2025/11/soutenance-de-these-yasmine-pobiedonoscew.jpg
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