{"id":19923,"global_id":"www.bricbordeaux.com\/en\/?id=19923","global_id_lineage":["www.bricbordeaux.com\/en\/?id=19923"],"author":"3","status":"publish","date":"2022-06-16 12:29:18","date_utc":"2022-06-16 10:29:18","modified":"2022-06-22 09:43:36","modified_utc":"2022-06-22 07:43:36","url":"https:\/\/www.bricbordeaux.com\/en\/event\/sbm-department-seminar-sabine-colnot\/","rest_url":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/tribe\/events\/v1\/events\/19923","title":"SBM Department Seminar &#8211; Sabine Colnot","description":"<p><a href=\"https:\/\/www.crcordeliers.fr\/equipes\/oncogenic-functions-of-b-catenin-signaling-in-the-liver\/\" target=\"_blank\" rel=\"noopener\"><strong>Sabine Colnot<\/strong><\/a>, <a href=\"https:\/\/www.crcordeliers.fr\/\" target=\"_blank\" rel=\"noopener\">Centre de Recherche des Cordeliers<\/a>, Paris, will speak on June 28 at 3:00 pm, amphitheater 11, Carreire campus.<\/p>\n<p>Invited by <a href=\"https:\/\/www.bricbordeaux.com\/people\/violaine-moreau\/\" target=\"_blank\" rel=\"noopener\">Violaine Moreau<\/a>, team leader of the<a href=\"https:\/\/www.bricbordeaux.com\/bric-team\/liver-cancers-and-tumor-invasion\/\" target=\"_blank\" rel=\"noopener\">Team 03 &#8211; Liver Cancers and Tumor Invasion<\/a>.<\/p>\n<p><em><strong>&#8220;CRISPR-Cas9-engineered mice developing liver cancers with beta-catenin mutation: towards a better understanding of liver carcinogenesis&#8221;<\/strong><\/em><\/p>\n<p>One third of hepatocellular carcinoma (HCC) have mutations activating beta-catenin signaling. We definitely showed that these mutations are oncogenic in mice (Loesch et al., J Hepatol 2022), and are responsible for the development of HCC and mesenchymal hepatoblastoma. This mouse model and a previous one obtained through a loss of function of Apc are valuable preclinical models to better understand why a large subset of beta-catenin activated HCCs are resistant to immunotherapies. Our work further supports the hypothesis that they could be treated based on their metabolism (Gougelet et al., Gastroenterol 2019; Senni et al., Gut 2019). 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