{"id":43649,"date":"2022-06-28T15:00:00","date_gmt":"2022-06-28T13:00:00","guid":{"rendered":"https:\/\/www.bricbordeaux.com\/2022\/06\/sbm-department-seminar-sabine-colnot\/"},"modified":"2023-07-07T12:41:12","modified_gmt":"2023-07-07T10:41:12","slug":"sbm-department-seminar-sabine-colnot","status":"publish","type":"post","link":"https:\/\/www.bricbordeaux.com\/en\/2022\/06\/sbm-department-seminar-sabine-colnot\/","title":{"rendered":"SBM Department Seminar &#8211; Sabine Colnot"},"content":{"rendered":"<p><a href=\"https:\/\/www.crcordeliers.fr\/equipes\/oncogenic-functions-of-b-catenin-signaling-in-the-liver\/\" target=\"_blank\" rel=\"noopener\"><strong>Sabine Colnot<\/strong><\/a>, <a href=\"https:\/\/www.crcordeliers.fr\/\" target=\"_blank\" rel=\"noopener\">Centre de Recherche des Cordeliers<\/a>, Paris, will speak on June 28 at 3:00 pm, amphitheater 11, Carreire campus.<\/p>\n<p>Invited by <a href=\"https:\/\/www.bricbordeaux.com\/people\/violaine-moreau\/\" target=\"_blank\" rel=\"noopener\">Violaine Moreau<\/a>, team leader of the<a href=\"https:\/\/www.bricbordeaux.com\/bric-team\/liver-cancers-and-tumor-invasion\/\" target=\"_blank\" rel=\"noopener\">Team 03 &#8211; Liver Cancers and Tumor Invasion<\/a>.<\/p>\n<p><em><strong>&#8220;CRISPR-Cas9-engineered mice developing liver cancers with beta-catenin mutation: towards a better understanding of liver carcinogenesis&#8221;<\/strong><\/em><\/p>\n<p>One third of hepatocellular carcinoma (HCC) have mutations activating beta-catenin signaling. We definitely showed that these mutations are oncogenic in mice (Loesch et al., J Hepatol 2022), and are responsible for the development of HCC and mesenchymal hepatoblastoma. This mouse model and a previous one obtained through a loss of function of Apc are valuable preclinical models to better understand why a large subset of beta-catenin activated HCCs are resistant to immunotherapies. Our work further supports the hypothesis that they could be treated based on their metabolism (Gougelet et al., Gastroenterol 2019; Senni et al., Gut 2019). Lastly, the CRISPR-Cas9 strategy appears to be an easy-to-use approach to investigate the oncogenic function of specific mutations in HCC.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Sabine Colnot, Centre de Recherche des Cordeliers, Paris, will speak on June 28 at 3:00 pm, amphitheater 11, Carreire campus. Invited by Violaine Moreau, team leader of theTeam 03 &#8211; Liver Cancers and Tumor Invasion. &#8220;CRISPR-Cas9-engineered mice developing liver cancers with beta-catenin mutation: towards a&#8230;<\/p>\n","protected":false},"author":3,"featured_media":19803,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111],"tags":[],"class_list":["post-43649","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news"],"_links":{"self":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/43649","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/comments?post=43649"}],"version-history":[{"count":1,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/43649\/revisions"}],"predecessor-version":[{"id":44193,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/43649\/revisions\/44193"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media\/19803"}],"wp:attachment":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media?parent=43649"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/categories?post=43649"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tags?post=43649"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}