{"id":51276,"date":"2026-03-24T12:08:09","date_gmt":"2026-03-24T11:08:09","guid":{"rendered":"https:\/\/www.bricbordeaux.com\/2026\/03\/new-article-from-the-mircade-team-a-promising-breakthrough-in-the-fight-against-hepatoblastoma\/"},"modified":"2026-03-24T16:26:03","modified_gmt":"2026-03-24T15:26:03","slug":"new-article-from-the-mircade-team-a-promising-breakthrough-in-the-fight-against-hepatoblastoma","status":"publish","type":"post","link":"https:\/\/www.bricbordeaux.com\/en\/2026\/03\/new-article-from-the-mircade-team-a-promising-breakthrough-in-the-fight-against-hepatoblastoma\/","title":{"rendered":"New article from the MIRCADE team. A promising breakthrough in the fight against hepatoblastoma"},"content":{"rendered":"\n

A promising breakthrough in the fight against hepatoblastoma<\/strong><\/h2>\n\n

Team 6 MIRCADE<\/a> (Methods and Innovations for Research on Childhood Cancers), led byDr. Christophe Grosset<\/a> , a Research Director at Inserm, has just published a significant article in the prestigious journal Molecular Cancer<\/em>, shedding new light on hepatoblastoma, the most common form of liver cancer in children. This work is part of a translational research initiative aimed at identifying new therapeutic solutions and accelerating their transition to clinical practice.<\/p>\n\n

Hepatoblastoma is a rare liver tumor that primarily affects children under the age of five. While current treatment strategies, which combine chemotherapy and surgery, generally yield good results, aggressive or chemotherapy-resistant forms of this cancer continue to be associated with a poor prognosis, underscoring the need to develop new targeted approaches.<\/p>\n\n

In this study, researchers demonstrated that the EZH2 protein promotes the development of hepatoblastoma, particularly the most aggressive tumors. They then targeted the EZH2 protein with a specific inhibitor, GSK126, and found that the treatment-resistant cells produced significant amounts of lipids. By combining GSK126 with a statin, they were able to effectively destroy cancer cells and block tumor growth in an animal model. Typically prescribed to lower cholesterol, statins are the subject of extensive research in oncology, and their use in combination with other treatments appears very promising for many types of cancer.<\/p>\n\n

These results demonstrate the potential of repurposing existing drugs as a rapid and effective way to provide new treatment options for children with cancer, particularly those with resistant and aggressive forms of the disease.<\/p>\n\n

These studies, published in a leading scientific journal, attest to the high quality of the research conducted by our teams at the Bordeaux Institute of Oncology and their dynamism, and demonstrate our commitment to developing innovative approaches in pediatric oncology.<\/p>\n\n

\n
\n
<\/i>Inserm Press Release<\/span><\/a><\/div>\n<\/div>\n\n\n\n
\n
<\/i>Article published in Molecular Cancer<\/em><\/span><\/a><\/div>\n<\/div>\n<\/div>\n
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Thanks to our funders!<\/p>\n\n

Groupama Centre-AtlantiqueLa R\u00e9gion Nouvelle-AquitaineLa Fondation Groupama pour la Sant\u00e9l\u2019Institut National du Cancer (INCa)La Fondation Bergoni\u00e9the Foundation for Addies\u2019s Research,La Ligue Nationale contre le CancerInstituto de Salud Carlos IIIEuropean Union’s Horizon 2020 research and innovation programCatalan Agency for Management of University and Research Grantsthe Ram\u00f3n y Cajal program of the Spanish Ministry of Science and InnovationImagine for MargoFoundation KickCancerAidons MarinaE.S.CA.P.E.Eva pour la VieLes R\u00e9coltes de l\u2019EspoirPour EmmaScott & CoCIBERehdAGAURthe Scientific Foundation of the Spanish Association Against CancerFight Kids Cancer Funding ProgramFoundation Kriibskrank Kanner and Federazione italiana Associazioni Genitori e Guariti Oncoematologia PediatricaCris Cancer Foundationthe Agency for Management of University and Research GrantsCassandraNathana\u00ebl du R\u00eave et de l\u2019EspoirNo\u00ebline ma Fille ma BatailleSph\u00e8resWarrior Enguerrand<\/p>\n","protected":false},"excerpt":{"rendered":"

A promising breakthrough in the fight against hepatoblastoma Team 6 MIRCADE (Methods and Innovations for Research on Childhood Cancers), led byDr. Christophe Grosset , a Research Director at Inserm, has just published a significant article in the prestigious journal Molecular Cancer, shedding new light on…<\/p>\n","protected":false},"author":3,"featured_media":51273,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111,8],"tags":[],"class_list":["post-51276","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news","category-uncategorized"],"_links":{"self":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/51276","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/comments?post=51276"}],"version-history":[{"count":2,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/51276\/revisions"}],"predecessor-version":[{"id":51278,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/posts\/51276\/revisions\/51278"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media\/51273"}],"wp:attachment":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media?parent=51276"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/categories?post=51276"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tags?post=51276"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}