{"id":20535,"date":"2022-09-01T15:26:59","date_gmt":"2022-09-01T13:26:59","guid":{"rendered":"https:\/\/www.bricbordeaux.com\/event\/oncosphere-interdisciplinary-seminar-anthony-bouter-and-frederic-saltel\/"},"modified":"2023-03-16T17:52:33","modified_gmt":"2023-03-16T16:52:33","slug":"oncosphere-interdisciplinary-seminar-anthony-bouter-and-frederic-saltel","status":"publish","type":"tribe_events","link":"https:\/\/www.bricbordeaux.com\/en\/event\/oncosphere-interdisciplinary-seminar-anthony-bouter-and-frederic-saltel\/","title":{"rendered":"Oncosphere Interdisciplinary Seminar. Anthony Bouter and Fr\u00e9d\u00e9ric Saltel"},"content":{"rendered":"

Anthony Bouter, UMR5248 CBMN<\/a>, Bordeaux and Fr\u00e9d\u00e9ric Saltel, U1312 BRIC<\/a>, Bordeaux will speak at the Oncosphere’s<\/a> interdisciplinary seminars the 7 septembre at 12pm<\/strong>,conference room at IBGC<\/strong> and videoconference<\/a>.<\/p>\n

\"\"<\/p>\n

Fr\u00e9d\u00e9ric Saltel<\/strong><\/a>
\nBRIC INSERM 1312, Team 03 – Liver Cancers and Tumor Invasion<\/a>.<\/p>\n

\n
\n

Cancer cells transfer invasive properties through tracks, a novel collagen-associated extracellular vesicle entity<\/strong><\/p>\n

Metastasis is the leading cause of cancer-related deaths. During this process, tumor cells acquire invasive and migratory capacities in order to invade the surrounding tissues. To achieve this, the tumor microenvironment including the extracellular matrix (ECM) is altered to facilitate cancer cell proliferation and dissemination. Extracellular vesicles (EVs), such as exosomes or migrasomes, are already known to induce pro-tumor features such as migration, promoting tumor development and metastasis formation. Here we highlight a new type of EVs, referred as tracks, released by cancer cells during migration and specifically attached along collagen fibers. These tracks, identified by discoidin receptor 1 (DDR1) enrichment, are promoted when cell-ECM interactions are increased, such as in tumors. We characterized these tracks, their ultrastructure as well as their molecular composition in terms of proteins and nucleic acids, showing that they are different from classical EVs known so far. Moreover, these tracks are very stable structures and can be internalized by surrounding cells. After internalization, they modify the differentiation status and the phenotype of recipient cells, promoting epithelial to mesenchymal transition, matrix degradation and invasion.<\/p>\n

Thus, we identified a new class of collagen-associated EVs, tracks, that play a role in cell-cell communication by transferring invasive properties. Consequently, these cancer-related tracks could be a new player in the tumor invasion process.<\/p>\n<\/div>\n<\/div>\n

\"\"<\/p>\n

Anthony Bouter<\/strong>
\nInstitute of Chemistry & Biology of Membranes & Nano-objects \u2022 Bordeaux \u2013 UMR5248
\nBordeaux university<\/p>\n

\n
\n

Inhibition de la r\u00e9paration membranaire dans la lutte contre la formation de m\u00e9tastases<\/strong><\/p>\n

Lors du processus de m\u00e9tastase, les cellules canc\u00e9reuses invasives sont soumises \u00e0 des contraintes m\u00e9caniques importantes et subissent des dommages de leur membrane plasmique, l\u2019enveloppe lipidique protectrice qui entoure chacune de nos cellules. Elles ne doivent leur survie qu\u2019\u00e0 des m\u00e9canismes de r\u00e9paration membranaire exacerb\u00e9s. Notre objectif est de caract\u00e9riser cette machinerie et de d\u00e9velopper les outils mol\u00e9culaires capables de l\u2019inhiber et ainsi de limiter l\u2019invasion tumorale et la formation de m\u00e9tastases.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"

Anthony Bouter, UMR5248 CBMN, Bordeaux and Fr\u00e9d\u00e9ric Saltel, U1312 BRIC, Bordeaux will speak at the Oncosphere’s interdisciplinary seminars the 7 septembre at 12pm,conference room at IBGC and videoconference. Fr\u00e9d\u00e9ric Saltel BRIC INSERM 1312, Team 03 – Liver Cancers and Tumor Invasion. Cancer cells transfer invasive…<\/p>\n","protected":false},"author":3,"featured_media":20524,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[91,93],"class_list":["post-20535","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-meetings-en","tribe_events_cat-seminars-en","cat_meetings-en","cat_seminars-en"],"_links":{"self":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/20535","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":1,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/20535\/revisions"}],"predecessor-version":[{"id":42779,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/20535\/revisions\/42779"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media\/20524"}],"wp:attachment":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media?parent=20535"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tags?post=20535"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events_cat?post=20535"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}