{"id":47308,"date":"2024-07-04T14:59:26","date_gmt":"2024-07-04T12:59:26","guid":{"rendered":"https:\/\/www.bricbordeaux.com\/event\/invited-seminar-pr-alain-gobert-2024-07-16\/"},"modified":"2024-07-12T12:36:34","modified_gmt":"2024-07-12T10:36:34","slug":"invited-seminar-pr-alain-gobert-2024-07-16","status":"publish","type":"tribe_events","link":"https:\/\/www.bricbordeaux.com\/en\/event\/invited-seminar-pr-alain-gobert-2024-07-16\/","title":{"rendered":"Invited seminar &#8211; Pr. Alain Gobert &#8211; 2024-07-16"},"content":{"rendered":"<p><a href=\"https:\/\/www.bricbordeaux.com\/people\/christine-varon\/\" target=\"_blank\" rel=\"noopener\">Christine Varon<\/a>,<a href=\"https:\/\/www.bricbordeaux.com\/bric-team\/equipe-4-cancers-digestifs-associes-a-linfection-par-helicobacter-cellules-souches-cancereuses-et-strategies-therapeutiques\/\" target=\"_blank\" rel=\"noopener\">team 04 &#8211; Helicobacter-associated digestive cancers, cancer stem cells and therapeutic strategies<\/a> , invites Pr Alain Gobert to present a seminar.<\/p>\n<p><strong><a href=\"https:\/\/medicine.vumc.org\/department-directory\/Alain-P-Gobert\" target=\"_blank\" rel=\"noopener\">Pr Alain Gobert<\/a><br \/>\n<\/strong><span class=\"break-words tvm-parent-container\"><span dir=\"ltr\">Research Professor of Medicine, <\/span><\/span>Division of Gastroenterology, Hepatology and Nutrition, Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center<br \/>\nNashville, TN, USA<\/p>\n<p><strong><em>Role of polyamines and electrophilic stress in gastrointestinal carcinogenesis: Therapeutic implications.<\/em><\/strong><\/p>\n<p>Gastric cancer (GC) is the fourth leading cause of cancer death worldwide. The intestinal type of GC is initiated by the pathogen <em>Helicobacter pylori<\/em>, which infects half of the world\u2019s population. The three biogenic polyamines, putrescine, spermidine, and spermine play key functions in a variety of cellular processes and are essential for cellular homeostasis. Using animal models of <em>H. pylori<\/em>-mediated diseases, we showed that the enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, plays a major role in development of gastritis and gastric dysplasia. This occurs notably through the generation of acrolein, a reactive aldehyde that initiates lipid peroxidation and further generation of bifunctional electrophiles. A potent scavenger of these molecules attenuates gastric carcinogenesis. Similar results were then obtained in models of sporadic or colitis-associated colorectal cancers.      <\/p>\n<p>\ud83d\udccc BBS conference room, 2 rue Dr Hoffamnn Martinot &#8211; Bordeaux<\/p>\n<p>\ud83d\udcc6 16\/07\/2024, 11 am<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Christine Varon,team 04 &#8211; Helicobacter-associated digestive cancers, cancer stem cells and therapeutic strategies , invites Pr Alain Gobert to present a seminar. Pr Alain Gobert Research Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center&#8230;<\/p>\n","protected":false},"author":3,"featured_media":47321,"template":"","meta":{"_tribe_events_status":"","_tribe_events_status_reason":"","footnotes":""},"tags":[],"tribe_events_cat":[91,93],"class_list":["post-47308","tribe_events","type-tribe_events","status-publish","has-post-thumbnail","hentry","tribe_events_cat-meetings-en","tribe_events_cat-seminars-en","cat_meetings-en","cat_seminars-en"],"_links":{"self":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/47308","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events"}],"about":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/types\/tribe_events"}],"author":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/users\/3"}],"version-history":[{"count":2,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/47308\/revisions"}],"predecessor-version":[{"id":47319,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events\/47308\/revisions\/47319"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media\/47321"}],"wp:attachment":[{"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/media?parent=47308"}],"wp:term":[{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tags?post=47308"},{"taxonomy":"tribe_events_cat","embeddable":true,"href":"https:\/\/www.bricbordeaux.com\/en\/wp-json\/wp\/v2\/tribe_events_cat?post=47308"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}