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
- pylori peut induire l’apparition de lymphome gastrique du MALT en raison de la stimulation antigénique constante conduisant à l’expansion des lymphocytes B. Notre hypothèse de travail est qu’une co-infection Helicobacter/Escherichia coli favorise la lymphomagenèse gastrique.
Le microbiote gastrique et intestinal sera exploré. Des analyses bactériologiques, histologiques, moléculaires et métagénomiques nous permettront de répondre à plusieurs questions :
L’infection à E. coli favorise-t-elle la lymphomagenèse gastrique induite par Helicobacter ?
L’infection à E. coli influence-t-elle la réponse inflammatoire gastrique ?
Les facteurs de virulence de E. coli, en particulier la colibactine, sont-ils impliqués dans ces processus ?
Nos approches expérimentales par métagénomique permettront d’identifier la nature des taxons et ou des fonctions associées à ces modifications du microbiote.
En perspective, il sera d’un intérêt majeur de valider les modifications taxonomiques et fonctionnelles observées au sein de la communauté microbienne en modèle murin, sur des biopsies de patients atteints de lymphome gastrique du MALT.
Collaborations: Pr MJ Blaser, Rutgers University, New Jersey; Pr R Bonnet, CHU Clermont Ferrand ; Pr A Amiot, Hôpital Henri Mondor, Créteil, and Hôpital Saint Antoine, Paris-APHP; Pr B Huard, TRAIG, TIMC-IMAG, UMR 5525, university Grenoble-Alpes, La Tronche, France.