Équipe émergente – I.CaRe (programme intégré de recherche & Innovation sur le Cancer du Rein)
The BRIC-U1312 laboratory’s emerging “Kidney Cancer” team is a fantastic opportunity to bring together the scientific expertise of BRIC and the multidisciplinary clinical expertise of Bordeaux University Hospital practitioners (Pr BERNHARD, Dr MARGUE, Dr GROSS-GOUPIL, Dr LEFORT, Dr YACOUB, Dr JAMBON, Dr MORGAT) in the field of kidney tumours. Its aim is to develop a local translational biological or technological research activity, drawing on the resources and pre-existing structure of the integrated research and innovation program on kidney cancer: I.CaRe Bordeaux.
The I.CaRe team, led by Professor Bernhard of the Department of Urology, Andrology and Renal Transplantation, is responsible for a portfolio of projects of excellence in care, research and teaching (https://icare-bordeaux.fr/). This program aims to improve knowledge and management of kidney tumors through innovation, research and self-evaluation, by developing multi-partner academic and industrial research projects in 4 areas:
These activities are supported by the Renal Surgery Research and Innovation Fund.
Site web de l‘équipe LinkedIn YouTube
UroCCR, the French Kidney Cancer Research Network, has been accredited by the French National Cancer Institute as a Clinico-Biological Basis for National Cancer Research.
Today, UroCCR is a national multidisciplinary medical-scientific network focused on therapeutic management and applied research in kidney cancer. It relies on a health data warehouse, accessible on the Internet (www.uroccr.fr), deployed in 53 French centers (University Hospitals, Private Hospitals, Cancer Centers). This prospective health data warehouse enables the continuous, secure acquisition of real-life data (demographic, clinical, data associated with biological samples, PREMS, PROMS, as well as experimental results).
With over 8 million data records, it represents a major asset for epidemiological, observational, interventional or translational (biological and technological) research projects, and for the prospective evaluation of real-life care practices, through the creation of a truly integrated pathway combining Care and Research.
Over 190 research projects have been carried out within the framework of the Network, with an average permanent active file of around twenty studies. These include retrospective projects based on existing data, prospective interventional projects and translational research.
UroCCR is currently included in the list of databases and real-life studies identified and likely to be used to respond to requests for additional data from the HAS for the evaluation of healthcare products and technologies (https://www.has-sante.fr/jcms/p_3333630/fr/etudes-en-vie-reelle-recensement-des-sources-de-donnees-mobilisables-pour-repondre-aux-demandes-de-la-has).
Matching with the SNDS via the UroCCR-Chain EDS will extend the scope of the information collected and enable the development of projects linked to the medico-economic evaluation of health trajectories.
UroCCR’s aims cover the following areas:
– Promote research initiatives on this pathology by structuring national resources and capacities
– Create a multicentric collection of annotated biological samples
– Generate prospective research projects of all categories and in different thematic fields
– Enable any data controller meeting the required formalities to reuse the data it contains for research, evaluation or knowledge enhancement purposes in the following thematic fields:
Can Simplified PADUA Renal (SPARE) Nephrometry scoring system help predict renal function outcomes after robot-assisted partial nephrectomy? (UroCCR study 93).
Klein C, Margue G, Champy C, Parier B, Waeckel T, Bensalah K, Olivier J, Doumerc N, Audenet F, Branger N, Roupret M, Surlemont L, Bruyere F, Durand X, Durand M, Long JA, Gaillard V, Xylinas E, Vallee M, Rouget B, Bigot P, Bernhard JC
Minerva urology and nephrology ; 2023 Oct 01
Feasibility of salvage robotic partial nephrectomy after ablative treatment failure (UroCCR-62 study).
Margue G, Michiels C, Allenet C, Dupitout L, Ricard S, Jambon E, Blanc P, Alezra E, Estrade V, Capon G, Bladou F, Robert G, Grenier N, Bernhard JC
Minerva urology and nephrology ; 2022 Apr 01
Does the Time to Start First-Line Treatment Influence the Survival of Favorable-Risk Patients With Metastatic Renal Cell Carcinoma? Results of the MetaSurv-UroCCR 79 Study.
Rolley C, Barthelemy P, Bensalah K, Nouhaud FX, Villers A, Bruyère F, Lebdai S, Ricard S, Gross-Goupil M, Rouprêt M, Bernhard JC, Bigot P
Clinical genitourinary cancer ; 2023 Feb 01
Late complications and 5 years outcomes of robotic partial nephrectomy in France: prospective assessment in the French Kidney Cancer Research Network (UroCCR 10).
Margue G, Ingels A, Bensalah K, Doumerc N, Vaessen C, Roupret M, Audenet F, Mejean A, Bruyere F, Olivier J, Baumert H, Michel C, Paparel P, Parier B, Sebe P, Long JA, Lang H, Lebret T, Patard JJ, Bernhard JC
World journal of urology ; 2023 Aug 01
Feasibility of robotic-assisted partial nephrectomy for complete remission of metastatic renal cell carcinoma after long exposure to immune checkpoint inhibitors (UroCCR-106).
Mebroukine S, Yacoub M, Michiels C, Ravaud A, Gross-Goupil M, Bernhard JC
Journal of surgical case reports ; 2022 Dec 07
The Digital Urology 3D University Hospital Research Program (www.digital-urology-3d.fr) is a technological program drawing on the clinical expertise of members of the UroCCR French kidney cancer research network, and on the industrial and academic research capabilities of consortium members. The project combines these skills with the latest technological advances (medical imaging processing, artificial intelligence, radiomics, virtual and augmented reality, 3D printing, surgical simulation) with a triple objective:
Technological innovations in the fields of image-guided robotic surgery (virtual and augmented reality) and 3D printing introduced into care and teaching practice.
Percutaneous tumor ablation versus image guided robotic-assisted partial nephrectomy for cT1b renal cell carcinoma: a comparative matched-pair analysis (UroCCR 80).
Klein C, Cazalas G, Margue G, Piana G, DE Kerviler E, Gangi A, Puech P, Nedelcu C, Grange R, Buy X, Michiels C, Jegonday MA, Rouviere O, Grenier N, Marcelin C, Bernhard JC
Minerva urology and nephrology ; 2023 Oct 01
Three Dimensional Printing Technology Used to Create a High-Fidelity Ureteroscopy Simulator: Development and Validity Assessment (Rein-3D-Print-UroCCR-39).
Boulenger de Hauteclocque A, Michiels C, Sarrazin J, Faessel M, Sabatier J, Khaddad A, Margue G, Grenier N, Bos F, Estrade V, Bernhard JC
Urology ; 2023 Jun 01
A survey of augmented reality methods to guide minimally invasive partial nephrectomy.
Khaddad A, Bernhard JC, Margue G, Michiels C, Ricard S, Chandelon K, Bladou F, Bourdel N, Bartoli A
World journal of urology ; 2023 Feb 01
Digital innovations, including the development of :
– The UroConnect digital tool: a perioperative remote monitoring application to provide perioperative support for patients with kidney tumors (coordination of care paths).
– UroPREDICT artificial intelligence tool: UroPredict draws on data from the UroCCR network to generate algorithms and deploy them nationwide throughout the network, for clinical research purposes.
UroPredict won the “Data, AI & Healthcare Pathways” call for expressions of interest issued by the Comité Stratégique de Filière des Industries et Technologies de Santé on behalf of the French government.
Founded by the Université de Bordeaux and the CHU de Bordeaux, it represents a platform for simulation, teaching and research & development in robotic surgery.
Part of the Collège Santé de l’Université de Bordeaux surgical school, the center is equipped with several surgical robots for multidisciplinary use. Surgeons and future surgeons can train in near-real-life situations on 3D-printed biomimetic models.
– Protocols for improved post-operative rehabilitation and ambulatory care
– Innovative organizational experiments in the healthcare system
– Evaluation of UroCCR Practice
Nurse-led coordinated surgical care pathways for cost optimization of robotic-assisted partial nephrectomy: medico-economic analysis of the UroCCR-25 AMBU-REIN study.
Bernhard JC, Robert G, Ricard S, Rogier J, Degryse C, Michiels C, Margue G, Blanc P, Alezra E, Estrade V, Capon G, Bladou F, Ferriere JM
World journal of urology ; 2023 Feb 01
Day-case robotic-assisted partial nephrectomy: feasibility and preliminary results of a prospective evaluation (UroCCR-25 AMBU-REIN study).
Bernhard JC, Robert G, Ricard S, Michiels C, Capon G, Boulenger de Hautecloque A, Bensadoun H, Gay J, Rogier J, Tauzin-Fin P, Gross-Goupil M, Benard A, Nouette K, Roullet S, Ferrière JM
World journal of urology ; 2022 Jun 01
Jean-Christophe BERNHARD
Professor Clinician / PU-PH
Jean-Christophe BERNHARD
Professor Clinician / PU-PH
Arna GESHKOVSKA
Engineer / IE
Nicolas GIRAUD
Clinician / PH
Marine GROSS-GOUPIL
Clinician / PH
Thibaud HAASER
Clinician / PH
Guillaume HERMAN
Engineer / IE
Manon JAFFREDO
Engineer / IE
Eva JAMBON
Clinician / PH
Félix LEFORT
Clinician / PH
Gaëlle MARGUE
Clinician / PH
Clément MORGAT
Clinician / PH
Clémence MORICE
Clinician Assistant / CCA
Solène RICARD
Engineer / IE
Julie TINAT
Clinician / PH
Mokrane YACOUB
Clinician / PH