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Invited seminar – Pr. Alain Gobert – 2024-07-16

16 July à 11h00 - 12h00

Christine Varon,team 04 – Helicobacter-associated digestive cancers, cancer stem cells and therapeutic strategies , invites Pr Alain Gobert to present a seminar.

Pr Alain Gobert
Research Professor of Medicine, Division of Gastroenterology, Hepatology and Nutrition, Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center
Nashville, TN, USA

Role of polyamines and electrophilic stress in gastrointestinal carcinogenesis: Therapeutic implications.

Gastric cancer (GC) is the fourth leading cause of cancer death worldwide. The intestinal type of GC is initiated by the pathogen Helicobacter pylori, which infects half of the world’s population. The three biogenic polyamines, putrescine, spermidine, and spermine play key functions in a variety of cellular processes and are essential for cellular homeostasis. Using animal models of H. pylori-mediated diseases, we showed that the enzyme spermine oxidase (SMOX), which back-converts spermine to spermidine, plays a major role in development of gastritis and gastric dysplasia. This occurs notably through the generation of acrolein, a reactive aldehyde that initiates lipid peroxidation and further generation of bifunctional electrophiles. A potent scavenger of these molecules attenuates gastric carcinogenesis. Similar results were then obtained in models of sporadic or colitis-associated colorectal cancers.

📌 BBS conference room, 2 rue Dr Hoffamnn Martinot – Bordeaux

📆 16/07/2024, 11 am


16 July
11h00 - 12h00
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Salle de conférence BBS (Bordeaux Biologie Santé)
2 rue Dr Hoffmann Martinot
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