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Publication of Jean-Max Pasquet’s team
Read the article written by Candice Ménégon for the SBM Department on the recent publication of Team 10 – Normal and Leukemic Hematopoietic Stem Cells, directed by Jean-Max Pasquet.
Targeting autophagy and hematologic mobilization in FLT3-ITD acute myeloid leukemia (1/3 of patients) decreases repopulation capacity and relapse by inducing apoptosis.
Work carried out thanks to the cell culture device in hypoxia (low oxygen level in the oven and the hood) mimicking the hematopoietic niche. This device is accessible to the scientific community through the CellOxia platform associated with the team.
Scientific article: Dupont, Marine et al. “Autophagy Targeting and Hematological Mobilization in FLT3-ITD Acute Myeloid Leukemia Decrease Repopulating Capacity and Relapse by Inducing Apoptosis of Committed Leukemic Cells.” Cancers vol. 14,2 453. 17 Jan. 2022, doi:10.3390/cancers14020453