Frederic Delom and his 2.2 team have invited Cédric Chaveroux to present his research.

Cédric Chaveroux, Laboratoire de Biologie tissulaire et Ingénierie Thérapeutique – UMR 5305, Lyon

Titre :
A non-canonical RNA damage signaling drives cell plasticity under translational stress: implications for colorectal tumor cell state transitions. (english presentation).

Biosketch

Dr Cédric Chaveroux is a CNRS researcher and head of the Microenvironmental Stress Signaling and Epithelial Cell Fate team. His work focuses on the mechanisms by which epithelial tumor cells adapt to stress, with a particular emphasis on RNA damage responses and cellular plasticity. His research investigates signaling pathways activated in response to alterations in RNA integrity, particularly under conditions of translational stress and disrupted cellular homeostasis. He is especially interested in GCN2 kinase–mediated signaling as a key sensor and integrator of stress, capable of reprogramming gene expression and cell fate decisions. In this context, he explores how translation perturbations induced by microenvironmental and/or therapeutic stress contribute to the remodeling of cellular states and promote tumor progression.

Abstract

Beyond its role in protein synthesis, mRNA translation constitutes a central hub for stress response integration. Under microenvironmental or therapy-induced stress conditions, its disruption triggers a coordinated set of molecular pathways collectively referred to as the RNA damage response. The dynamic interplay between these pathways plays a critical role in determining tumor cell fate. Our recent work identifies novel signaling mechanisms that enable tumor cells to tolerate translational stress, thereby promoting their survival and plasticity in colorectal cancer. Beyond redefining the key molecular events underlying tumor cell plasticity, pharmacological targeting of these mechanisms represents a promising therapeutic opportunity.