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Invited seminar – Thomas Bertero – 14-05-2025

14 May 2025 à 15h00 - 16h00

Invited seminar by Violaine Moreau, Team 3, Liver Cancers and Tumor Invasion and Isabelle Sagot, Quiessence and Multicellularity Team, IBGC

Thomas Bertero is CRCN CNRS, CNRS Bronze Medal 2019. He studies the link between the mechanical response of cells to their environment and metabolism.
Institut de Pharmacologie moléculaire et cellulaire (IPMC)
Université Côte d’Azur/CNRS/Inserm
Valbonne

Title: Mechano-metabolism: From tissues to molecules
Abstract :
The spatiotemporal control of cell behaviour requires the transmission of information from the complex structure of tissues to their constituent cells. Mechanotransduction enables this transmission by sensing mechanical environments and adapting cellular behaviours. However, this process requires energy. Since our pioneering study demonstrating a link between cell mechanics and cell metabolism (Bertero et al, J Clin Invest 2016) our laboratory has been interested in deciphering how tissue mechanical properties shape – and are shaped by – cell metabolism. Here, I will summarise our recent discoveries on how the mechanical properties of the tumour niche reprogram glutamine and glucose metabolism to promote breast cancer progression.

📆 Wednesday, May 14, 3pm
📌 Amphi BBS (Bordeaux Biologie Santé) 2 rue du Dr Hoffmann Martinot

Selected publications:
Mechano-dependent sorbitol accumulation supports biomolecular condensate.

Torrino S, Oldham WM, Tejedor AR, Burgos IS, Nasr L, Rachedi N, Fraissard K, Chauvet C, Sbai C, O’Hara BP, Abélanet S, Brau F, Favard C, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T. Cell. 2025 Jan 23;188(2):447-464.e20. doi: 10.1016/j.cell.2024.10.048.
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.

Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. J Clin Invest. 2022 May 16;132(10):e161077. doi: 10.1172/JCI161077.
Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand.

Torrino S, Bertero T. Trends Cell Biol. 2022 Jul;32(7):624-636. doi: 10.1016/j.tcb.2022.01.013. Epub 2022 Feb 14.
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.

Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. Cell Metab. 2021 Jul 6;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009.
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.

Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012.
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.

Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J 3rd, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. J Clin Invest. 2016 Sep 1;126(9):3313-35. doi: 10.1172/JCI86387.

Details

Date:
14 May 2025
Time:
15h00 - 16h00
Event Categories:
,

Venue

  • Salle de conférence BBS (Bordeaux Biologie Santé)
  • 2 rue Dr Hoffmann Martinot
    Bordeaux,     + Google Map

Organizer

  • BRIC