Séminaire invité par Violaine Moreau, équipe 3, Cancers du Foie et Invasion Tumorale et Isabelle Sagot, équipe Quiessence et Multicellularité, IBGC
Thomas Bertero est CRCN CNRS, médaille de bronze du CNRS 2019. Il étudie le lien entre la réponse mécanique des cellules à leur environnement et le métabolisme.
Institut de Pharmacologie moléculaire et cellulaire (IPMC)
Université Côte d’Azur/CNRS/Inserm
Valbonne
Titre: Mechano-metabolism: From tissues to molecules
Résumé :
The spatiotemporal control of cell behaviour requires the transmission of information from the complex structure of tissues to their constituent cells. Mechanotransduction enables this transmission by sensing mechanical environments and adapting cellular behaviours. However, this process requires energy. Since our pioneering study demonstrating a link between cell mechanics and cell metabolism (Bertero et al, J Clin Invest 2016) our laboratory has been interested in deciphering how tissue mechanical properties shape – and are shaped by – cell metabolism. Here, I will summarise our recent discoveries on how the mechanical properties of the tumour niche reprogram glutamine and glucose metabolism to promote breast cancer progression.
📆 Mercredi 14 mai, 15h
📌 Amphi BBS (Bordeaux Biologie Santé) 2 rue du Dr Hoffmann Martinot
Selected publications:
Mechano-dependent sorbitol accumulation supports biomolecular condensate.
Torrino S, Oldham WM, Tejedor AR, Burgos IS, Nasr L, Rachedi N, Fraissard K, Chauvet C, Sbai C, O’Hara BP, Abélanet S, Brau F, Favard C, Clavel S, Collepardo-Guevara R, Espinosa JR, Ben-Sahra I, Bertero T. Cell. 2025 Jan 23;188(2):447-464.e20. doi: 10.1016/j.cell.2024.10.048.
Systems-level regulation of microRNA networks by miR-130/301 promotes pulmonary hypertension.
Bertero T, Lu Y, Annis S, Hale A, Bhat B, Saggar R, Saggar R, Wallace WD, Ross DJ, Vargas SO, Graham BB, Kumar R, Black SM, Fratz S, Fineman JR, West JD, Haley KJ, Waxman AB, Chau BN, Cottrill KA, Chan SY. J Clin Invest. 2022 May 16;132(10):e161077. doi: 10.1172/JCI161077.
Metabo-reciprocity in cell mechanics: feeling the demands/feeding the demand.
Torrino S, Bertero T. Trends Cell Biol. 2022 Jul;32(7):624-636. doi: 10.1016/j.tcb.2022.01.013. Epub 2022 Feb 14.
Mechano-induced cell metabolism promotes microtubule glutamylation to force metastasis.
Torrino S, Grasset EM, Audebert S, Belhadj I, Lacoux C, Haynes M, Pisano S, Abélanet S, Brau F, Chan SY, Mari B, Oldham WM, Ewald AJ, Bertero T. Cell Metab. 2021 Jul 6;33(7):1342-1357.e10. doi: 10.1016/j.cmet.2021.05.009.
Tumor-Stroma Mechanics Coordinate Amino Acid Availability to Sustain Tumor Growth and Malignancy.
Bertero T, Oldham WM, Grasset EM, Bourget I, Boulter E, Pisano S, Hofman P, Bellvert F, Meneguzzi G, Bulavin DV, Estrach S, Feral CC, Chan SY, Bozec A, Gaggioli C. Cell Metab. 2019 Jan 8;29(1):124-140.e10. doi: 10.1016/j.cmet.2018.09.012.
Vascular stiffness mechanoactivates YAP/TAZ-dependent glutaminolysis to drive pulmonary hypertension.
Bertero T, Oldham WM, Cottrill KA, Pisano S, Vanderpool RR, Yu Q, Zhao J, Tai Y, Tang Y, Zhang YY, Rehman S, Sugahara M, Qi Z, Gorcsan J 3rd, Vargas SO, Saggar R, Saggar R, Wallace WD, Ross DJ, Haley KJ, Waxman AB, Parikh VN, De Marco T, Hsue PY, Morris A, Simon MA, Norris KA, Gaggioli C, Loscalzo J, Fessel J, Chan SY. J Clin Invest. 2016 Sep 1;126(9):3313-35. doi: 10.1172/JCI86387.
