Thesis defense in computer science

Florian ROBERT, team 06 – MIRCADE, Methods and Innovations for the Research in Pediatric Cancers.

Co-supervision of thesis: Christophe Grosset (BRIC) and Baudouin Denis de Senneville (IMB- Institut des Mathématiques de Bordeaux)

Monday, September 29, 2 p.m.

“Exploration de l’organisation interne des tissus tumoraux par imagerie volumétrique, méthodes numériques et apprentissage profond.”

Salle des Actes bâtiment A33 campus Sciences et Technologies à Talence

Abstract:

Understanding the internal organization of tumor tissues is essential for improving cancer treatment in children. This thesis focuses on hepatoblastoma, the most common malignant liver tumor in children. Based on 3D electron microscopy images, a digital twin of the tumor tissue was created using innovative tools to automatically segment and identify biological structures such as cells, nuclei or blood capillaries. This information was then used to analyze the internal organization of the tissue using unsupervised learning methods. This work opens the way to a better understanding of tumor architecture, and ultimately aims to improve diagnosis, choose the best treatment and better care for children with cancer.

Jury members:

Ms Karin PERNET GALLAY, Research Engineer, University of Grenoble Alpes, Rapporteur
M. Charles KERVRANN, Directeur de Recherche, Université de Rennes, Rapporteur
Mrs. Nataliya SOKOLOVSKA, Professor, Sorbonne University, Examiner
Ms Christèle ETCHEGARAY, Research Fellow, University of Bordeaux, Examiner
M. Baudouin DENIS DE SENNEVILLE, Directeur de Recherche, Université de Bordeaux, Directeur
M. Christophe F. GROSSET, Directeur de Recherche, Université de Bordeaux, Co-Directeur